Posttranslational modifications of collagens as targets of hypoxia and Hif-1α in endochondral bone development

Annals of the New York Academy of Sciences

Volumn 1192, Issue , 2010, Pages 317-321

  Schipani, Ernestina ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chondrocytes; Collagen; Hif 1 ; Hypoxia; Matrix; VHL

Indexed keywords

COLLAGEN; COLLAGEN TYPE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEOGLYCAN;

ANIMAL CELL; CARTILAGE CELL; CELL DIFFERENTIATION; CELL SURVIVAL; CHONDROGENESIS; CONFERENCE PAPER; ENCHONDRAL OSSIFICATION; ENVIRONMENT; FETUS GROWTH; GROWTH PLATE; HYPOXIA; IN VIVO STUDY; MEDIATOR; MESENCHYME; NONHUMAN; OXYGENATION; PROTEIN PROCESSING; REGULATORY MECHANISM;

EID: 77950663501     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05236.x     Document Type: Conference Paper

References (40)

1. Rodesch, F. et al. 1992. Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy. Obstet. Gynecol. 80: 283-285.
2. Chen, E. Y., M. Fujinaga & A. J. Giaccia. 1999. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology 60: 215-225.
3. Simon, M. C. & B. Keith. 2008. The role of oxygen availability in embryonic development and stemcell function. Nat. Rev. Mol. Cell Biol. 9: 285-296.
4. Giaccia, A. J., M. C. Simon & R. Johnson. 2004. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes. Dev. 18: 2183-2194.
5. Giaccia, A., B. Siim & R. Johnson. 2003. HIF-1 as a target for drug development.Nat. Rev. Drug Discov. 2: 803-811.
6. Kaelin, W. 2002. How oxygen makes its presence felt. Genes. Dev. 16: 1441-1445.
7. Liu, L. &M. C. Simon. 2004. Regulation of transcription and translation by hypoxia. Cancer Biol. Ther. 3: 492-497.
8. Semenza,G. L. 2003. TargetingHIF-1 for cancer therapy. Nat. Rev. Cancer 3: 721-732.
9. Pouyssegur, J., F. Dayan & N. M.Mazure. 2006. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443.
10. Leo, C.,A.Giaccia&N.Denko. 2004. The hypoxic tumor microenvironment and gene expression. Semin Radiat. Oncol. 14: 207-214.
11. Greijer, A. E. et al. 2005. Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J. Pathol. 206: 291-304.
12. Bishop, T. et al. 2004. Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS Biol. 2: e289.
13. Ryan, H. E., J. Lo & R. S. Johnson. 1998. HIF 1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17: 3005-3015.
14. Iyer, N. et al. 1998. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1alpha. Genes. Dev. 12: 149-162.
15. Compernolle,V. et al. 2003.Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor -1alpha. Cardiovascular Res. 60: 569-579
16. Karsenty, G. 2003. The complexities of skeletal biology. Nature 423: 316-318.
17. Schwartz, N. &M. Domowicz. 2002. Chondrodysplasias due to proteoglycan defects. Glycobiology 12: 57R-68R.
18. Olsen,B. R. 1996.Role of cartilage collagens in formation of the skeleton. Ann. N.Y. Acad. Sci. 785: 124-130.
19. Schipani, E. et al. 2001.Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes. Dev. 15: 2865-2876.
20. Provot, S. et al. 2007.Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J. Cell Biol. 177: 451-464.
21. Amarilio, R. et al. 2007. Hif1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early chondrogenesis. Development 134: 3917-3928.
22. Jeong, C. et al. 2007. Hypoxia-inducible factor -1alpha inhibits self-renewal of mouse embryonic stem cells in vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway. J. Biol. Chem. 282: 13672-13679.
23. Lin, Q., Y. Lee & Z. Yun. 2006. Differentiation arrest by hypoxia. J. Biol. Chem. 281: 30678-30683.
24. Sainson, R. & A. Harris. 2006. Hypoxia-regulated differentiation: let's step it up a Notch. Trends Mol. Med. 12: 141-143.
25. Gustafsson, M. et al. 2005. Hypoxia requires Notch signaling to maintain the undifferentiated cell state. Dev. Cell 9: 617-628.
26. Salim, A. et al. 2004. Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J. Biol. Chem. 279: 40007-40016.
27. Yun, Z., Q. Lin & A. Giaccia. 2005. Adaptive myogenesis under hypoxia. Mol. Cell Biol. 25: 3040-3055.
28. Yun, Z. et al. 2002. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC-1/Stra13 a mechanism for regulation of adipogenesis by hypoxia. Dev. Cell 2: 331-341.
29. Dahl, K. C. et al. 2005.Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.Mol. Cell Biol. 25: 10479-10491.
30. Morrison, S. J. et al. 2000. Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells. J. Neurosci. 20: 7370-7376.
31. Studer, L. et al. 2000. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J. Neurosci. 20: 7377-7383.
32. Khatri, R. & E. Schipani. 2008. About the importance of being desulfated. Genes. Dev. 22: 2750-2754.
33. Hirsila, M. et al. 2003. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J. Biol. Chem. 278: 30772-30780.
34. Grimmer, C. et al. 2006. Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen tension. Am. J. Pathol. 169: 491-502.
35. Egerbacher,M. & G.Haeusler. 2003. Integrins in growth plate cartilage. Pediatr. Endocrinol. Rev. 1: 2-8.
36. Tsang, K. et al. 2007. Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function. PLoS Biol. 5: e44.
37. Higgins, D. F. et al. 2008. Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle 7: 1128-1132.
38. Erler, J. T. et al. 2009. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 15: 35-44.
39. Robins, J. C. et al. 2005. Hypoxia induces chondrocytespecific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone 37: 313-322.
40. Lefebvre, V. & P. Smits. 2005. Transcriptional control of chondrocyte fate and differentiation. Birth Defects Res. C Embryo Today 75: 200-212.