Loss of β-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans

Journal of Neuroscience

Volumn 30, Issue 14, 2010, Pages 4857-4867

  Perkins, Emma M ^a   Clarkson, Yvonne L ^a   Sabatier, Nancy ^a   Longhurst, David M ^a   Millward, Christopher P ^a   Jack, Jennifer ^a   Toraiwa, Junko ^a   Watanabe, Mitsunori ^b   Rothstein, Jeffrey D ^c   Lyndon, Alastair R ^d   Wyllie, David J A ^a   Dutia, Mayank B ^a   Jackson, Mandy ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b HIROSAKI UNIVERSITY   (Japan)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER 4; GLUTAMIC ACID; SPECTRIN; SPECTRIN BETA III SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CEREBELLAR ATAXIA; CEREBELLUM ATROPHY; CONTROLLED STUDY; DEGENERATIVE DISEASE; FEMALE; GAIT DISORDER; GLUTAMATERGIC TRANSMISSION; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOTOR COORDINATION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PURKINJE CELL; SODIUM CURRENT; SPINOCEREBELLAR ATAXIA TYPE 5; TREMOR;

ACTION POTENTIALS; ANIMALS; ATROPHY; CEREBELLUM; GAIT; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOTOR ACTIVITY; PURKINJE CELLS; SPECTRIN; SPINOCEREBELLAR ATAXIAS; TREMOR;

EID: 77950618122     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6065-09.2010     Document Type: Article

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