Torsades de pointes during complete atrioventricular block: Genetic factors and electrocardiogram correlates

Canadian Journal of Cardiology

Volumn 26, Issue 4, 2010, Pages 208-212

  Subbiah, Rajesh N ^a   Gollob, Michael H ^b   Gula, Lorne J ^a   Davies, Robert W ^b   Leong Sit, Peter ^a   Skanes, Allan C ^a   Yee, Raymond ^a   Klein, George J ^a   Krahn, Andrew D ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

AV block; Bradycardia; Genetics; QT interval; Torsades de pointes

Indexed keywords

POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNE2; POTASSIUM CHANNEL KCNH2; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

AGED; ARTICLE; ATRIOVENTRICULAR BLOCK; CLINICAL ARTICLE; CLINICAL ASSESSMENT; ELECTROCARDIOGRAPHY; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETIC VARIABILITY; HEREDITY; HUMAN; LONG QT SYNDROME; MALE; PHENOTYPE; PROSPECTIVE STUDY; QT INTERVAL; SUDDEN DEATH; SYNCOPE; TELEMETRY; TORSADE DES POINTES;

EID: 77950611981     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0828-282X(10)70369-X     Document Type: Article

References (38)

1. Wilson FN, Robinson CC. Two cases of complete heart block showing unusual features. Arch Intern Med 1918;21:166-175
2. Dessertenne F. La tachycardia ventriculaire a deux foyers opposes variable. Arch Mal Coeur Vaiss 1966;59:263-272
3. Vincent GM. The long-QT syndrome - bedside to bench to bedside. N Engl J Med 2003;348:1837-1838
4. Kurita T, Ohe T, Marui N, et al. Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes. Am J Cardiol 1992;69:628-633
5. Strasberg B, Kusniec J, Erdman S, et al. Polymorphous ventricular tachycardia and atrioventricular block. Pacing Clin Electrophysiol 1986;9:522-526 (Pubitemid 16100198)
6. Topilski I, Rogowski O, Rosso R, et al. The morphology of the QT interval predicts torsade de pointes during acquired bradyarrhythmias. J Am Coll Cardiol 2007;49:320-328 (Pubitemid 46110956)
7. Yoshida H, Horie M, Otani H, Kawashima T, Onishi Y, Sasayama S. Bradycardia-induced long QT syndrome caused by a de novo missense mutation in the S2-S3 inner loop of HERG. Am J Med Genet 2001;98:348-352 (Pubitemid 32126015)
8. Chevalier P, Bellocq C, Millat G, et al. Torsades de pointes complicating atrioventricular block: Evidence for a genetic predisposition. Heart Rhythm 2007;4:170-174 (Pubitemid 46170226)
9. Napolitano C, Schwartz PJ, Brown AM, et al. Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life- threatening arrhythmias. J Cardiovasc Electrophysiol 2000;11:691-696 (Pubitemid 30397542)
10. Yang P, Kanki H, Drolet B, et al. Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation 2002;105:1943-1948 (Pubitemid 34437622)
11. McLaughlin NB, Campbell RW, Murray A. Comparison of automatic QT measurement techniques in the normal 12 lead electrocardiogram. Br Heart J 1995;74:84-89
12. Bazett HC. An analysis of the time relations of electrocardiograms. Heart 1920;7:353-367
13. Smits JP, Koopmann TT, Wilders R, et al. A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families. J Mol Cell Cardiol 2005;38:969-981 (Pubitemid 40725945)
14. Chung SK, MacCormick JM, McCulley CH, et al. Long QT and Brugada syndrome gene mutations in New Zealand. Heart Rhythm 2007;4:1306-1314 (Pubitemid 47457201)
15. Vos MA, de Groot SH, Verduyn SC, et al. Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling. Circulation 1998;98:1125-1135
16. Volders PG, Sipido KR, Vos MA, et al. Downregulation of delayed rectifier K( + ) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes. Circulation 1999;100:2455-2461
17. Volders PG, Sipido KR, Vos MA, Kulcsar A, Verduyn SC, Wellens HJ. Cellular basis of biventricular hypertrophy and arrhythmogenesis in dogs with chronic complete atrioventricular block and acquired torsade de pointes. Circulation 1998;98:1136-1147 (Pubitemid 28420706)
18. Tsuji Y, Opthof T, Yasui K, et al. Ionic mechanisms of acquired QT prolongation and torsades de pointes in rabbits with chronic complete atrioventricular block. Circulation 2002;106:2012-2018 (Pubitemid 35176310)
19. Van Opstal JM, Leunissen JD, Wellens HJ, Vos MA. Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of torsade de pointes arrhythmias. Eur J Pharmacol 2001;412:67-76.
20. Swynghedauw B, Baillard C, Milliez P. The long QT interval is not only inherited but is also linked to cardiac hypertrophy. J Mol Med 2003;81:336-345 (Pubitemid 36783237)
21. Kubota T, Horie M, Takano M, et al. Evidence for a single nucleotide polymorphism in the KCNQ1 potassium channel that underlies susceptibility to life-threatening arrhythmias. J Cardiovasc Electrophysiol 2001;12:1223-1229 (Pubitemid 33111888)
22. Splawski I, Timothy KW, Tateyama M, et al. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science 2002;297:1333-1336 (Pubitemid 34913168)
23. Roden DM, Viswanathan PC. Genetics of acquired long QT syndrome. J Clin Invest 2005;115:2025-2032
24. Antzelevitch C. Heterogeneity and cardiac arrhythmias: An overview. Heart Rhythm 2007;4:964-972 (Pubitemid 46959206)
25. Antzelevitch C. The role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol 2007;293:H2024-38. (Pubitemid 47605847)
26. Bezzina C, Veldkamp MW, van den Berg MP, et al. A single Na( + ) channel mutation causing both long-QT and Brugada syndromes. Circ Res 1999;85:1206-1213 (Pubitemid 30430627)
27. van den Berg MP, Wilde AA, Viersma TJW, et al. Possible bradycardic mode of death and successful pacemaker treatment in a large family with features of long QT syndrome type 3 and Brugada syndrome. J Cardiovasc Electrophysiol 2001;12:630-636
28. Grant AO, Carboni MP, Neplioueva V, et al. Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation. J Clin Invest 2002;110:1201-1209 (Pubitemid 35215901)
29. Priori SG, Napolitano C, Schwartz PJ, Bloise R, Crotti L, Ronchetti E. The elusive link between LQT3 and Brugada syndrome: The role of flecainide challenge. Circulation 2000;102:945-947 (Pubitemid 30656000)
30. Remme CA, Verkerk AO, Nuyens D, et al. Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD. Circulation 2006;114:2584-2594 (Pubitemid 44967341)
31. Veldkamp MW, Viswanathan PC, Bezzina C, Baartscheer A, Wilde AA, Balser J.R. Two distinct congenital arrhythmias evoked by a multidysfunctional Na( + ) channel. Circ Res 2000;86:E91-E97.
32. Arnestad M, Crotti L, Rognum TO, et al. Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation 2007;115:361-367 (Pubitemid 46148510)
33. Ackerman MJ, Tester DJ, Jones GS, Will ML, Burrow CR, Curran ME. Ethnic differences in cardiac potassium channel variants: Implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome. Mayo Clin Proc 2003;78:1479-1487
34. Paavonen KJ, Chapman H, Laitinen PJ, et al. Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG). Cardiovasc Res 2003;59:603-611 (Pubitemid 38368676)
35. Pietila E, Fodstad H, Niskasaari E, et al. Association between HERG K897T polymorphism and QT interval in middle-aged Finnish women. J Am Coll Cardiol 2002;40:511-514 (Pubitemid 34833168)
36. Ackerman MJ, Splawski I, Makielski JC, et al. Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: Implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing. Heart Rhythm 2004;1:600-607 (Pubitemid 39462721)
37. Viswanathan PC, Benson DW, Balser JR. A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation. J Clin Invest 2003;111:341-346 (Pubitemid 36182210)
38. Ye B, Valdivia CR, Ackerman MJ, Makielski JC. A common human SCN5A polymorphism modifies expression of an arrhythmia causing mutation. Physiol Genomics 2003;12:187-193 (Pubitemid 37139698)