New insights into the biogenesis of nuclear RNA polymerases?

Biochemistry and Cell Biology

Volumn 88, Issue 2, 2010, Pages 211-221

  Cloutier, Philippe ^a   Coulombe, Benoit ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Biogenesis; Protein affinity purification; RNA polymerase; RNA polymerase II associated proteins (RPAPs); Transcription

Indexed keywords

COMPLEXATION; MACHINERY; MASS SPECTROMETRY; POLYMERS; PURIFICATION; RNA; TRANSCRIPTION;

DATA SETS; FALSE NEGATIVES; FALSE POSITIVE; HIGH-DENSITY; HUMAN CELL EXTRACTS; INTERACTION NETWORKS; INTERACTORS; MACHINE-LEARNING; NUCLEAR RNA; PROTEIN AFFINITY; RNA POLYMERASE; RNA POLYMERASE II; RNA POLYMERASE II-ASSOCIATED PROTEINS (RPAPS); SOLUBLE FRACTION;

PROTEINS;

CELL EXTRACT; NUCLEAR RNA; PROTEIN; RNA POLYMERASE; RNAP II ASSOCIATED PROTEIN; UNCLASSIFIED DRUG; DNA DIRECTED RNA POLYMERASE;

BIOGENESIS; CONFERENCE PAPER; ENZYME SUBUNIT; ENZYME SYNTHESIS; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; GENETIC TRANSCRIPTION; MASS SPECTROMETRY; PROTEIN PURIFICATION; VALIDATION PROCESS; ANIMAL; BIOSYNTHESIS; CELL NUCLEUS; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM;

ANIMALS; CELL NUCLEUS; DNA-DIRECTED RNA POLYMERASES; HUMANS;

EID: 77950601816     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/O09-173     Document Type: Conference Paper

References (90)

1. Bardoni, B., Schenck, A., and Mandel, J.L. 1999. A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Hum. Mol. Genet. 8(13): 2557-2566. doi:10.1093/hmg/8.13.2557. PMID:10556305.
2. Blank, J.L., Gerwins, P., Elliott, E.M., Sather, S., and Johnson, G.L. 1996. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J. Biol. Chem. 271(10): 5361-5368. PMID: 8621389.
3. Boulon, S., Marmier-Gourrier, N., Pradet-Balade, B., Wurth, L., Verheggen, C., Jády, B.E., et al. 2008. The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J. Cell Biol. 180(3): 579-595. doi:10.1083/jcb.200708110. PMID:18268104.
4. Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P.O., Bergamini, G., Croughton, K., et al. 2004. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. 6(2): 97-105. doi:10.1038/ncb1086. PMID:14743216.
5. Brajenovic, M., Joberty, G., Küster, B., Bouwmeester, T., and Drewes, G. 2003. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J. Biol. Chem. 279(13): 12804-12811. doi:10.1074/jbc.M312171200. PMID:14676191.
6. Čabart, P., Chew, H.K., and Murphy, S. 2004. BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II. Oncogene, 23(31): 5316-5329. doi:10.1038/sj.onc.1207684. PMID:15107825.
7. Carey, M. 1998. The enhanceosome and transcriptional synergy. Cell, 92(1): 5-8. doi:10.1016/S0092-8674(00)80893-4. PMID: 9489694.
8. Chang, L., and Karin, M. 2001. Mammalian MAP kinase signalling cascades. Nature, 410(6824): 37-40. doi:10.1038/35065000. PMID:11242034.
9. Chao, T.H., Hayashi, M., Tapping, R.I., Kato, Y., and Lee, J.D. 1999. MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. J. Biol. Chem. 274(51): 36035-36038. doi:10.1074/jbc.274.51.36035. PMID:10593883.
10. Cloutier, P., Al-Khoury, R., Lavallée-Adam, M., Faubert, D., Jiang, H., Poitras, C., et al. 2009. High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes. Methods, 48(4): 381-386. doi:10.1016/j.ymeth.2009.05.005. PMID:194506872E
11. Conaway, R.C., and Conaway, J.W. 1997. General transcription factors for RNA polymerase II. Prog. Nucleic Acid Res. Mol. Biol. 56: 327-346. doi:10.1016/S0079-6603(08)61009-0. PMID: 9187058.
12. Conaway, R.C., Sato, S., Tomomori-Sato, C., Yao, T., and Conaway, J.W. 2005. The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem. Sci. 30(5): 250-255. doi:10.1016/j.tibs.2005.03.002. PMID:15896743.
13. Coulombe, B., and Burton, Z.F. 1999. DNA bending and wrapping around RNA polymerase: A "revolutionary" model describing transcriptional mechanisms. Microbiol. Mol. Biol. Rev. 63(2): 457-478. PMID:10357858.
14. Deacon, K., and Blank, J.L. 1997. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. J. Biol. Chem. 272(22): 14489-14496. doi:10.1074/jbc.272.22.14489. PMID:9162092.
15. Deacon, K., and Blank, J.L. 1999. MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases. J. Biol. Chem. 274(23): 16604-16610. doi:10.1074/jbc.274.23.16604. PMID:10347227.
16. Delgermaa, L., Hayashi, N., Dorjsuren, D., Nomura, T., Thuy, T.T., and Murakami, S. 2004. Subcellular localization of RPB5-mediating protein and its putative functional partner. Mol. Cell. Biol. 24(19): 8556-8566. doi:10.1128/MCB.24.19.8556-8566.2004. PMID:15367675.
17. Deplazes, A., Möckli, N., Luke, B., Auerbach, D., and Peter, M. 2009. Yeast Uri1p promotes translation initiation and may provide a link to cotranslational quality control. EMBO J. 28(10): 1429-1441. doi:10.1038/emboj. 2009.98. PMID:19387492.
18. Djouder, N., Metzler, S.C., Schmidt, A., Wirbelauer, C., Gstaiger, M., Aebersold, R., et al. 2007. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Mol. Cell, 28(1): 28-40. doi:10.1016/j.molcel.2007.08.010. PMID: 17936702.
19. Dorjsuren, D., Lin, Y., Wei, W., Yamashita, T., Nomura, T., Hayashi, N., and Murakami, S. 1998. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. Mol. Cell. Biol. 18(12): 7546-7555. PMID:9819440.
20. Ellinger-Ziegelbauer, H., Brown, K., Kelly, K., and Siebenlist, U. 1997. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J. Biol. Chem. 272(5): 2668-2674. doi:10.1074/jbc.272.5.2668. PMID:9006902.
21. Geissler, S., Siegers, K., and Schiebel, E. 1998. A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J. 17(4): 952-966. doi:10.1093/emboj/17.4.952. PMID:9463374.
22. Gibney, P.A., Fries, T., Bailer, S.M., and Morano, K.A. 2008. Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins. Eukaryot. Cell, 7(6): 938-948. doi:10.1128/EC.00042-08. PMID:18408053.
23. Giot, L., Bader, J.S., Brouwer, C., Chaudhuri, A., Kuang, B., Li, Y., et al. 2003. A protein interaction map of Drosophila melanogaster. Science, 302(5651): 1727-1736. doi:10.1126/science.1090289. PMID:14605208.
24. Gonzales, F.A., Zanchin, N.I., Luz, J.S., and Oliveira, C.C. 2005. Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in Pre-rRNA processing. J. Mol. Biol. 346(2): 437-455. doi:10.1016/j.jmb.2004.11.071. PMID:15670595.
25. Granato, D.C., Gonzales, F.A., Luz, J.S., Cassiola, F., Machado-Santelli, G.M., and Oliveira, C.C. 2005. Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae. FEBS J. 272(17): 4450-4463. doi:10.1111/j.1742-4658. 2005. 04861.x. PMID:16128814.
26. Gribun, A., Cheung, K.L., Huen, J., Ortega, J., and Houry, W.A. 2008. Yeast Rvb1 and Rvb2 are ATP-dependent DNA helicases that form a heterohexameric complex. J. Mol. Biol. 376(5): 1320-1333. doi:10.1016/j.jmb.2007.12.049. PMID:18234224.
27. Gstaiger, M., Luke, B., Hess, D., Oakeley, E.J., Wirbelauer, C., Blondel, M., et al. 2003. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science, 302(5648): 1208-1212. doi:10.1126/science.1088401. PMID: 14615539.
28. Hampsey, M. 1998. Molecular genetics of the RNA polymerase II general transcriptional machinery. Microbiol. Mol. Biol. Rev. 62(2): 465-503. PMID:9618449.
29. Hardeland, U., and Hurt, E. 2006. Coordinated nuclear import of RNA polymerase III subunits. Traffic, 7(4): 465-473. doi:10.1111/j.1600-0854.2006. 00399.x. PMID:16536744.
30. He, F., Umehara, T., Tsuda, K., Inoue, M., Kigawa, T., Matsuda, T., et al. 2007. Solution structure of the zinc finger HIT domain in protein FON. Protein Sci. 16(8): 1577-1587. doi:10.1110/ps.062635107. PMID:17656577.
31. Itsuki, Y., Saeki, M., Nakahara, H., Egusa, H., Irie, Y., Terao, Y., et al. 2008. Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. FEBS Lett. 582(16): 2365-2370. doi:10.1016/j.febslet.2008.05.041. PMID: 18538670.
32. Iwahashi, H., Yamagata, K., Yoshiuchi, I., Terasaki, J., Yang, Q., Fukui, K., et al. 2002. Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha. Diabetes, 51(4): 910-914. doi:10.2337/diabetes.51.4.910. PMID:11916906.
33. Jeronimo, C., Forget, D., Bouchard, A., Li, Q., Chua, G., Poitras, C., et al. 2007. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol. Cell, 27(2): 262-274. doi:10.1016/j.molcel.2007.06.027. PMID:17643375.
34. Kanemaki, M., Kurokawa, Y., Matsu-ura, T., Makino, Y., Masani, A., Okazaki, K., et al. 1999. TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a. J. Biol. Chem. 274(32): 22437-22444. doi:10.1074/jbc.274.32.22437. PMID:10428817.
35. Kemphues, K.J., Priess, J.R., Morton, D.G., and Cheng, N.S. 1988. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell, 52(3): 311-320. doi:10.1016/S0092-8674(88)80024-2. PMID:3345562.
36. Kim, E., Du, L., Bregman, D.B., and Warren, S.L. 1997. Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-mRNA. J. Cell Biol. 136(1): 19-28. doi:10.1083/jcb.136.1.19. PMID:9008700.
37. Kim, J.H., Choi, H.J., Kim, B., Kim, M.H., Lee, J.M., Kim, I.S., et al. 2006. Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis. Nat. Cell Biol. 8(6): 631-639. doi:10.1038/ncb1415. PMID:16699503.
38. King, T.H., Decatur, W.A., Bertrand, E., Maxwell, E.S., and Fournier, M.J. 2001. A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins. Mol. Cell. Biol. 21(22): 7731-7746. doi:10.1128/MCB.21.22.7731-7746.2001. PMID:11604509.
39. Kirchner, J., Vissi, E., Gross, S., Szoor, B., Rudenko, A., Alphey, L., and White-Cooper, H. 2008. Drosophila Uri, a PP1alpha binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity. BMC Mol. Biol. 9(1): 36. doi:10.1186/1471-2199-9-36. PMID:18412953.
40. Kornberg, R.D. 2005. Mediator and the mechanism of transcriptional activation. Trends Biochem. Sci. 30(5): 235-239. doi:10.1016/j.tibs.2005.03.011. PMID:15896740.
41. Kornberg, R.D., and Lorch, Y. 1999. Chromatin-modifying and -remodeling complexes. Curr. Opin. Genet. Dev. 9(2): 148-151. doi:10.1016/S0959-437X(99) 80022-7. PMID:10322131.
42. Li, B., Carey, M., and Workman, J.L. 2007. The role of chromatin during transcription. Cell, 128(4): 707-719. doi:10.1016/j.cell. 2007.01.015. PMID:17320508.
43. Liu, L., and McKeehan, W.L. 2002. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. Genomics, 79(1): 124-136. doi:10.1006/geno.2001.6679. PMID:11827465.
44. Lundin, V.F., Stirling, P.C., Gomez-Reino, J., Mwenifumbo, J.C., Obst, J.M., Valpuesta, J.M., and Leroux, M.R. 2004. Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin. Proc. Natl. Acad. Sci. U.S.A. 101(13): 4367-4372. doi:10.1073/pnas.0306276101. PMID:15070724.
45. Luo, X., Huang, Y., and Sheikh, M.S. 2003. Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. Oncogene, 22(46): 7247-7257. doi:10.1038/sj.onc.1207010. PMID:14562055.
46. Markus, S.M., Taneja, S.S., Logan, S.K., Li, W., Ha, S., Hittelman, A.B., et al. 2002. Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. Mol. Biol. Cell, 13(2): 670-682. doi:10.1091/mbc.01-10-0513. PMID:11854421.
47. Marr, M.T., 2nd, Isogai, Y., Wright, K.J., and Tjian, R. 2006. Coactivator cross-talk specifies transcriptional output. Genes Dev. 20(11): 1458-1469. doi:10.1101/gad.1418806. PMID: 16751183.
48. McGilvray, R., Walker, M., and Bartholomew, C. 2007. UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation. FEBS J. 274(15): 3960-3971. doi:10.1111/j.1742-4658.2007.05928.x. PMID:17635584.
49. McKeegan, K.S., Debieux, C.M., Boulon, S., Bertrand, E., and Watkins, N.J. 2007. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. Mol. Cell. Biol. 27(19): 6782-6793. doi:10.1128/MCB.01097-07. PMID: 17636026.
50. Miyao, T., and Woychik, N.A. 1998. RNA polymerase subunit RPB5 plays a role in transcriptional activation. Proc. Natl. Acad. Sci. U.S.A. 95(26): 15281-15286. doi:10.1073/pnas.95.26.15281. PMID:9860960.
51. Mosley, A.L., Pattenden, S.G., Carey, M., Venkatesh, S., Gilmore, J.M., Florens, L., et al. 2009. Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation. Mol. Cell, 34(2): 168-178. doi:10.1016/j.molcel.2009.02.025. PMID:19394294.
52. Moss, T.N., Vo, A., McKeehan, W.L., and Liu, L. 2007. UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation. In Vitro Cell. Dev. Biol. Anim. 43(3-4): 139-146. doi:10.1007/s11626-007-9016-6. PMID:17554592.
53. Newman, D.R., Kuhn, J.F., Shanab, G.M., and Maxwell, E.S. 2000. Box C/D snoRNA-associated proteins: two pairs of evolutionarily ancient proteins and possible links to replication and transcription. RNA, 6(6): 861-879. doi:10.1017/S1355838200992446. PMID:10864044.
54. Ni, L., Saeki, M., Xu, L., Nakahara, H., Saijo, M., Tanaka, K., and Kamisaki, Y. 2009. RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage. J. Cell. Biochem. 106(5): 920-928. doi:10.1002/jcb.22073. PMID: 19180575.
55. Nikolov, D.B., and Burley, S.K. 1997. RNA polymerase II transcription initiation: a structural view. Proc. Natl. Acad. Sci. U.S.A. 94(1): 15-22. doi:10.1073/pnas.94.1.15. PMID:8990153.
56. Nwachukwu, J.C., Li, W., Pineda-Torra, I., Huang, H.Y., Ruoff, R., Shapiro, E., et al. 2007. Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27. Mol. Endocrinol. 21(12): 2864-2876. doi:10.1210/me.2007-0094. PMID:17761951.
57. Orphanides, G., and Reinberg, D. 2000. RNA polymerase II elongation through chromatin. Nature, 407(6803): 471-476. doi:10.1038/35035000. PMID:11028991.
58. Orphanides, G., Lagrange, T., and Reinberg, D. 1996. The general transcription factors of RNA polymerase II. Genes Dev. 10(21): 2657-2683. doi:10.1101/gad.10.21.2657. PMID:8946909.
59. Parsons, G.G., and Spencer, C.A. 1997. Mitotic repression of RNA polymerase II transcription is accompanied by release of transcription elongation complexes. Mol. Cell. Biol. 17(10): 5791-5802. PMID:9315637.
60. Parusel, C.T., Kritikou, E.A., Hengartner, M.O., Krek, W., and Gotta, M. 2006. URI-1 is required for DNA stability in C. elegans. Development, 133(4): 621-629. doi:10.1242/dev.02235. PMID:16436622.
61. Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.E., Karandikar, M., Berman, K., and Cobb, M.H. 2001. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22(2): 153-183. doi:10.1210/er.22.2.153. PMID:11294822.
62. Ptashne, M., and Gann, A. 1997. Transcriptional activation by recruitment. Nature, 386(6625): 569-577. doi:10.1038/386569a0. PMID:9121580.
63. Puri, T., Wendler, P., Sigala, B., Saibil, H., and Tsaneva, I.R. 2007. Dodecameric structure and ATPase activity of the human TIP48/ TIP49 complex. J. Mol. Biol. 366(1): 179-192. doi:10.1016/j.jmb.2006.11.030. PMID:17157868.
64. Qiu, X.B., Lin, Y.L., Thome, K.C., Pian, P., Schlegel, B.P., Weremowicz, S., et al. 1998. An eukaryotic RuvB-like protein (RUVBL1) essential for growth. J. Biol. Chem. 273(43): 27786-27793. doi:10.1074/jbc.273.43.27786. PMID:9774387.
65. Roch, F., Serras, F., Cifuentes, F.J., Corominas, M., Alsina, B., Amorós, M., et al. 1998. Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. Mol. Gen. Genet. 257(2): 103-112. doi:10.1007/PL00008620. PMID: 9491068.
66. Roeder, R.G. 2005. Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett. 579(4): 909-915. doi:10.1016/j.febslet. 2004.12.007. PMID:15680973.
67. Saeki, M., Irie, Y., Ni, L., Yoshida, M., Itsuki, Y., and Kamisaki, Y. 2006. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha. Biochem. Biophys. Res. Commun. 342(2): 568-572. doi:10.1016/j.bbrc.2006.02.009. PMID:16487927.
68. Samanta, A.K., Huang, H.J., Bast, R.C., Jr., and Liao, W.S. 2004. Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. J. Biol. Chem. 279(9): 7576-7583. doi:10.1074/jbc.M311659200. PMID:14662759.
69. Sardiu, M.E., Cai, Y., Jin, J., Swanson, S.K., Conaway, R.C., Conaway, J.W., et al. 2008. Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. Proc. Natl. Acad. Sci. U.S.A. 105(5): 1454-1459. doi:10.1073/pnas.0706983105. PMID:18218781.
70. Scheufler, C., Brinker, A., Bourenkov, G., Pegoraro, S., Moroder, L., Bartunik, H., et al. 2000. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell, 101(2): 199-210. doi:10.1016/S0092-8674(00)80830-2. PMID:10786835.
71. Schmidt, C., Peng, B., Li, Z., Sclabas, G.M., Fujioka, S., Niu, J., et al. 2003. Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. Mol. Cell, 12(5): 1287-1300. doi:10.1016/S1097-2765(03)00390-3. PMID:14636585.
72. Schroer, A., Schneider, S., Ropers, H., and Nothwang, H. 1999. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. Genomics, 56(3): 340-343. doi:10.1006/geno.1998.5712. PMID:10087202.
73. Siegers, K., Waldmann, T., Leroux, M.R., Grein, K., Shevchenko, A., Schiebel, E., and Hartl, F.U. 1999. Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system. EMBO J. 18(1): 75-84. doi:10.1093/emboj/18.1.75. PMID:9878052.
74. Siegers, K., Bölter, B., Schwarz, J.P., Böttcher, U.M., Guha, S., and Hartl, F.U. 2003. TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes. EMBO J. 22(19): 5230-5240. doi:10.1093/emboj/cdg483. PMID:14517260.
75. Siegert, R., Leroux, M.R., Scheufler, C., Hartl, F.U., and Moarefi, I. 2000. Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins. Cell, 103(4): 621-632. doi:10.1016/S0092-8674(00)00165-3. PMID:11106732.
76. Sun, S., Tang, Y., Lou, X., Zhu, L., Yang, K., Zhang, B., et al. 2007. UXT is a novel and essential cofactor in the NF-κB transcriptional enhanceosome. J. Cell Biol. 178(2): 231-244. doi:10.1083/jcb.200611081. PMID:17620405.
77. Taneja, S.S., Ha, S., Swenson, N.K., Torra, I.P., Rome, S., Walden, P.D., et al. 2004. ART-27, an androgen receptor coactivator regulated in prostate development and cancer. J. Biol. Chem. 279(14): 13944-13952. doi:10.1074/jbc.M306576200. PMID: 14711828.
78. Te, J., Jia, L., Rogers, J., Miller, A., and Hartson, S.D. 2007. Novel subunits of the mammalian Hsp90 signal transduction chaperone. J. Proteome Res. 6(5): 1963-1973. doi:10.1021/pr060595i. PMID:17348703.
79. Tjian, R., and Maniatis, T. 1994. Transcriptional activation: a complex puzzle with few easy pieces. Cell, 77(1): 5-8. doi:10.1016/0092-8674(94)90227-5. PMID:8156597.
80. Triezenberg, S.J. 1995. Structure and function of transcriptional activation domains. Curr. Opin. Genet. Dev. 5(2): 190-196. doi:10.1016/0959- 437X(95)80007-7. PMID:7613088.
81. Uhlik, M.T., Abell, A.N., Johnson, N.L., Sun, W., Cuevas, B.D., Lobel-Rice, K.E., et al. 2003. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat. Cell Biol. 5(12): 1104-1110. doi:10.1038/ncb1071. PMID:14634666.
82. Vainberg, I.E., Lewis, S.A., Rommelaere, H., Ampe, C., Vandekerckhove, J., Klein, H.L., and Cowan, N.J. 1998. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell, 93(5): 863-873. doi:10.1016/S0092-8674(00)81446-4. PMID:9630229.
83. Venteicher, A.S., Meng, Z., Mason, P.J., Veenstra, T.D., and Artandi, S.E. 2008. Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell, 132(6): 945-957. doi:10.1016/j.cell. 2008.01.019. PMID:18358808.
84. Watts, J.L., Etemad-Moghadam, B., Guo, S., Boyd, L., Draper, B.W., Mello, C.C., et al. 1996. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development, 122(10): 3133-3140. PMID:8898226.
85. Wei, W., Gu, J.X., Zhu, C.Q., Sun, F.Y., Dorjsuren, D., Lin, Y., and Murakami, S. 2003. Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). Cell Res. 13(2): 111-120. doi:10.1038/sj.cr.7290155. PMID:12737519.
86. Yang, J., Lin, Y., Guo, Z., Cheng, J., Huang, J., Deng, L., et al. 2001. The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat. Immunol. 2(7): 620-624. doi:10.1038/89769. PMID:11429546.
87. Zariwala, M., O'Neal, W.K., Noone, P.G., Leigh, M.W., Knowles, M.R., and Ostrowski, L.E. 2004. Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia. Am. J. Respir. Cell Mol. Biol. 30(4): 428-434. doi:10.1165/rcmb.2003-0338RC. PMID:14630615.
88. Zhao, H., Wang, Q., Zhang, H., Liu, Q., Du, X., Richter, M., and Greene, M.I. 2005a. UXT is a novel centrosomal protein essential for cell viability. Mol. Biol. Cell, 16(12): 5857-5865. doi:10.1091/mbc.E05-08-0705. PMID:16221885.
89. Zhao, R., Davey, M., Hsu, Y.C., Kaplanek, P., Tong, A., Parsons, A.B., et al. 2005b. Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell, 120(5): 715-727. doi:10.1016/j.cell.2004.12.024. PMID:15766533.
90. Zhao, R., Kakihara, Y., Gribun, A., Huen, J., Yang, G., Khanna, M., et al. 2008. Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J. Cell Biol. 180(3): 563-578. doi:10.1083/jcb.200709061. PMID:18268103.