3′-[4-Aryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase

Journal of Medicinal Chemistry

Volumn 53, Issue 7, 2010, Pages 2902-2912

  Van Poecke, Sara ^a   Negri, Ana ^b   Gago, Federico ^b   Van Daele, Ineke ^a   Solaroli, Nicola ^c   Karlsson, Anna ^c   Balzarini, Jan ^d   Van Calenbergh, Serge ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c KAROLINSKA INSTITUTE   (Sweden)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 TRIAZOLE DERIVATIVE; 1,5 TRIAZOLE DERIVATIVE; 2,3' ANHYDRO 5' O TRIPHENYLMETHYL BETA 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 3 ' AZIDO 3' DEOXY BETA 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 3' (4 BENZYL 1,2,3 TRIAZOL 1 YL) 3' DEOXY BETA DEXTRO THYMIDINE; 3' (4 BUTYL 1,2,3 TRIAZOL 1 YL) 3' DEOXY BETA DEXTRO THYMIDINE; 3' (4 CHLOROPHENYL 1,2,3 TRIAZOL 1 YL) 3' DEOXY BETA 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 3' (4 CHLOROPHENYL 1,2,3 TRIAZOL 1 YL) 3' DEOXY BETA DEXTRO THYMIDINE; 3' (4 CYLOPENTYLMETHYL 1,2,3 TRIAZOL 1 YL) 3' DEOXY BETA DEXTRO THYMIDINE; 3' [4 5 (2 BROMOVINYL)(1,2,3 TRIAZOL 1 YL)] 3' DEOXYTHYMIDINE; 3' [5 (4 CHLOROPHENYL 1,2,3 TRIAZOL 1 YL] 3' DEOXY BETA DEXTRO THYMIDINE; 3' AZIDO 3' DEOXY 5' O TRIPHENYLMETHYL BETA 5 (2 BROMOVINYL)2' DEOXYURIDINE; 3' DEOXY 3' (4 PHENYL 1,2,3 TRIAZOL 1 YL) 3' DEOXY BETA DEXTRO THYMIDINE; 3' DEOXY 3' (4 PHENYL 1,2,3 TRIAZOL 1 YL) BETA 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 3' DEOXY 3' [4 (3,4 DICHLOROPHENYL) 1,2,3 TRIAZOL 1 YL]BETA DEXTRO THYMIDINE; 3' DEOXY 3' [4 PYRIDIN 2 YL 1,2,3 TRIAZOL 1 YL]BETA DEXTRO THYMIDINE; 3' DEOXY 3' [5 PHENYL 1,2,3 TRIAZOL 1 YL]BETA DEXTRO THYMIDINE; 5' O TRIPHENYLMETHYL BETA 5 (2 BROMOVINYL) 2' DEOXYURIDINE; ADENOSINE TRIPHOSPHATE; ALKYNE DERIVATIVE; COPPER; MITOCHONDRIAL ENZYME; RUTHENIUM; THYMIDINE DERIVATIVE; THYMIDINE KINASE; THYMIDINE KINASE 1; THYMIDINE KINASE 2; THYMIDINE KINASE INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ZIDOVUDINE; DRUG DERIVATIVE; ENZYME INHIBITOR; THYMIDINE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CONTROLLED STUDY; CYCLOADDITION; CYTOSTASIS; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; IC 50; METABOLISM; MITOCHONDRION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; CATALYTIC DOMAIN; CELL LINE, TUMOR; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MITOCHONDRIA; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE;

EID: 77950558113     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901532h     Document Type: Article

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