Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase

FEBS Journal

Volumn 275, Issue 9, 2008, Pages 2151-2160

  Mikkelsen, Nils E ^a   Munch Petersen, Birgitte ^b   Eklund, Hans ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b ROSKILDE UNIVERSITY   (Denmark)

Author keywords

Cancer gene therapy; Deoxyribonucleoside kinase; Nucleoside analogs; Pyrimidines; X ray structures

Indexed keywords

5 (2 BROMOVINYL) 2' DEOXYURIDINE; DEOXYRIBONUCLEOSIDE; DEOXYRIBONUCLEOSIDE KINASE; FLOXURIDINE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DROSOPHILA MELANOGASTER; DRUG BINDING; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE DIPHOSPHATE; ANIMALS; ANTIMETABOLITES; BROMODEOXYURIDINE; CYTARABINE; CYTIDINE TRIPHOSPHATE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEEDBACK; FLOXURIDINE; GUANOSINE TRIPHOSPHATE; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; THYMINE NUCLEOTIDES; X-RAY DIFFRACTION; ZALCITABINE; ZIDOVUDINE;

DROSOPHILA MELANOGASTER;

EID: 42449151667     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06369.x     Document Type: Article

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