Synthesis of a novel series of diphenolic chromone derivatives as inhibitors of NO production in LPS-activated RAW264.7 macrophages

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 8, 2010, Pages 2864-2871

  Liu, Guo Biao ^a   Xu, Jian Liang ^a   Geng, Mei ^a   Xu, Rui ^a   Hui, Rong Rong ^a   Zhao, Jian Wei ^a   Xu, Qiang ^a   Xu, Hong Xi ^b   Li, Jian Xin ^a  

^a NANJING UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Derivative; Diphenolic chromone; iNOS; Nitric oxide

Indexed keywords

(5,7 DIHYDROXY 4 OXO 4H CHROMEN 3 YL)METHYL 2 METHYLBENZOATE; (5,7 DIHYDROXY 4 OXO 4H CHROMEN 3 YL)METHYL 4 METHOXYBENZOATE; (5,7 DIHYDROXY 4 OXO 4H CHROMEN 3 YL)METHYL BENZOATE; ANTIINFLAMMATORY AGENT; CHROMONE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN; CELL STRAIN RAW 264 7; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CHROMONES; ENZYME INHIBITORS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II;

MURINAE;

EID: 77950518230     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.020     Document Type: Article

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