HSP65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration

Vaccine

Volumn 28, Issue 19, 2010, Pages 3312-3317

  Liang, Jin ^a   Aihua, Zhu ^b   Yu, Wang ^a   Yong, Lu ^a   Jingjing, Liu ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU NORMAL UNIVERSITY   (China)

Author keywords

HSP65; Mucosal administration; NOD; Peptide P277; Type 1 diabetes

Indexed keywords

ANTIDIABETIC AGENT; DRUG CARRIER; GAMMA INTERFERON; HEAT SHOCK PROTEIN 65; HSP65 5 P 277 FUSION PROTEIN; HYBRID PROTEIN; IGG2B ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; P 277; PEPTIDE VACCINE; UNCLASSIFIED DRUG; VALYLLEUCYLGLYCYLGLYCYLGLYCYLCYSTEINYLALANYLLEUCYLLEUCYL ARGINYLCYSTEINYLISOLEUCYLPROLYLALANYLLEUCYLASPARTYLSERYLLEUCYL THREONYLPROLYLALANYLASPARAGINYLGLUTAMYLASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE MODEL; DRUG EFFECT; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOPOTENTIATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TANDEM REPEAT; TREATMENT OUTCOME;

ADMINISTRATION, INTRANASAL; ANIMALS; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; DRUG CARRIERS; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; INFLAMMATION; MICE; MICE, INBRED NOD;

EID: 77950517710     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2010.02.100     Document Type: Article

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