Heat shock protein 60: Identification of specific epitopes for binding to primary macrophages

FEBS Letters

Volumn 580, Issue 1, 2006, Pages 115-120

  Habich, Christiane ^a   Kempe, Karina ^a   Gomez, Francisco J ^b   Lillicrap, Mark ^c   Gaston, Hill ^c   Van Der Zee, Ruurd ^d   Kolb, Hubert ^a   Burkart, Volker ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Binding epitope; Heat shock protein 60; Macrophages; Receptor

Indexed keywords

AMINO ACID; EPITOPE; HEAT SHOCK PROTEIN 60;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; EUKARYOTE; MACROPHAGE; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION;

ANIMALS; BACTERIAL PROTEINS; BONE MARROW CELLS; CELL LINE; CHAPERONIN 60; EPITOPES; HISTOPLASMA; HUMANS; MACROPHAGES; MICE; PROTEIN BINDING; SPECIES SPECIFICITY;

ANIMALIA; EUKARYOTA;

EID: 29344441017     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.11.060     Document Type: Article

References (33)

1. B. Bukau, E. Deuerling, C. Pfund, and E.A. Craig Getting newly synthesized proteins into shape Cell 101 2000 119 122
2. F.U. Hartl, and M. Hayer-Hartl Protein folding - molecular chaperones in the cytosol: from nascent chain to folded protein Science 295 2002 1852 1858
3. U. Feige, and I.R. Cohen The 65-kDa heat-shock protein in the pathogenesis of, prevention and therapy of autoimmune arthritis and diabetes mellitus in rats and mice Springer Semin. Immunopathol. 13 1991 99 113
4. S. Kamphuis, W. Kuis, W. de Jager, G. Teklenburg, M. Massa, G. Gordon, M. Boerhof, G.T. Rijkers, C.S. Uiterwaal, H.G. Otten, A. Sette, S. Albani, and B. Prakken Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis Lancet 366 2005 50 56
5. R. Abulafia-Lapid, D. Elias, I. Raz, Y. Keren-Zur, H. Atlan, and I.R. Cohen T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides J. Autoimmun. 12 1999 121 129
6. Q. Xu, G. Schett, H. Perschinka, M. Mayr, G. Egger, F. Oberhollenzer, J. Willeit, S. Kiechl, and G. Wick Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population Circulation 102 2000 14 20
7. W. van Eden, R. van der Zee, and B. Prakken Heat-shock proteins induce T-cell regulation of chronic inflammation Nat. Rev. Immunol. 5 2005 318 330
8. W. Chen, U. Syldath, K. Bellmann, V. Burkart, and H. Kolb Human 60-kDa heat-shock protein: a danger signal to the innate immune system J. Immunol. 162 1999 3212 3219
9. A. Kol, T. Bourcier, A.H. Lichtman, and P. Libby Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages J. Clin. Invest. 103 1999 571 577
10. R.M. Vabulas, P. Ahmad-Nejad, C. da Costa, T. Miethke, C.J. Kirschning, H. Häcker, and H. Wagner Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells J. Biol. Chem. 276 2001 31332 31339
11. S.B. Flohé, J. Brüggemann, S. Lendemans, M. Nikulina, G. Meierhoff, S. Flohé, and H. Kolb Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype J. Immunol. 170 2003 2340 2348
12. C. Habich, K. Baumgart, H. Kolb, and V. Burkart The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins J. Immunol. 168 2002 569 576
13. K. Ohashi, V. Burkart, S. Flohé, and H. Kolb Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex J. Immunol. 164 2000 558 561
14. C. Habich, K. Kempe, R. van der Zee, V. Burkart, and H. Kolb Different heat shock protein 60 species share pro-inflammatory activity but not binding sites on macrophages FEBS Lett. 533 2003 105 109
15. C. Habich, K. Kempe, V. Burkart, R. van der Zee, M. Lillicrap, H. Gaston, and H. Kolb Identification of the heat shock protein 60 epitope involved in receptor binding on macrophages FEBS Lett. 568 2004 65 69
16. C. Habich, K. Kempe, R. van der Zee, R. Rümenapf, H. Akiyama, H. Kolb, and V. Burkart Heat shock protein 60: specific binding of lipopolysaccharide J. Immunol. 174 2005 1298 1305
17. S. Jindal, A.K. Dudani, B. Singh, C.B. Harley, and R.S. Gupta Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen Mol. Cell. Biol. 9 1989 2279 2283
18. F.J. Gomez, A.M. Gomez, and G.S. Deepe Protective efficacy of a 62-kilodalton antigen, HIS-62, from the cell wall and cell membrane of Histoplasma capsulatum yeast cells Infect. Immun. 59 1991 4459 4464
19. F.J. Gomez, R. Allendoerfer, and G.S. Deepe Vaccination with recombinant heat shock protein 60 from Histoplasma capsulatum protects mice against pulmonary histoplasmosis Infect. Immun. 63 1995 2587 2595
20. G.S. Deepe, J.R. Gibbons, G.D. Brunner, and F.J. Gomez A protective domain of heat-shock protein 60 from Histoplasma capsulatum J. Infect. Dis. 174 1996 828 834
21. K. Braig, Z. Otwinowski, R. Hegde, D.C. Boisvert, A. Joachimiak, A.L. Horwich, and P.B. Sigler The crystal structure of the bacterial chaperonin GroEL at 2.8 Å Nature 371 1994 578 586
22. L. Brocchieri, and S. Karlin Conservation among HSP60 sequences in relation to structure, function, and evolution Protein Sci. 9 2000 476 486
23. Y. Wang, C.G. Kelly, J.T. Karttunen, T. Whittall, P.J. Lehner, L. Duncan, P. MacAry, J.S. Younson, M. Singh, W. Oehlmann, G. Cheng, L. Bergmeier, and T. Lehner CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines Immunity 15 2001 971 983
24. T. Becker, F.U. Hartl, and F. Wieland CD40, an extracellular receptor for binding and uptake of HSP70-peptide complexes J. Cell. Biol. 158 2002 1277 1285
25. S. Diment, M.S. Leech, and P.D. Stahl Generation of macrophage variants with 5-azacytidine: selection for mannose receptor expression J. Leukoc. Biol. 42 1987 485 490
26. S. Basu, R.J. Binder, T. Ramalingam, and P.K. Srivastava CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin Immunity 14 2001 303 313
27. Y. Delneste, G. Magistrelli, J. Gauchat, J. Haeuw, J. Aubry, K. Nakamura, N. Kawakami-Honda, L. Goetsch, T. Sawamura, J. Bonnefoy, and P. Jeannin Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation Immunity 17 2002 353 362
28. K. Gross, D. Hansch, R. Gastpar, and G. Multhoff Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94 Biol. Chem. 384 2003 267 279
29. J.R. Thériault, S.S. Mambula, T. Sawamura, M.A. Stevenson, and S.K. Calderwood Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells FEBS Lett. 579 2005 1951 1960
30. I.M. de Kleer, S.M. Kamphuis, G.T. Rijkers, L. Scholtens, G. Gordon, W. de Jager, R. Hafner, R. van der Zee, W. van Eden, W. Kuis, and B.J. Prakken The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10 Arthritis Rheum. 48 2003 2001 2010
31. I.M. de Kleer, L.R. Wedderburn, L.S. Taams, A. Patel, H. Varsani, M. Klein, W. de Jager, G. Pugayung, F. Giannoni, G.T. Rijkers, S. Albani, W. Kuis, and B. Prakken CD4+CD25 bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis J. Immunol. 172 2004 6435 6443
32. I.R. Cohen Peptide therapy for type 1 diabetes: the immunological homunculus and the rationale for vaccination Diabetolgia 45 2002 1468 1474
33. G. Wick, M. Knoflach, and Q. Xu Autoimmune and inflammatory mechanisms in atherosclerosis Annu. Rev. Immunol. 22 2004 361 403