Induction of Anergy in CD8 T Cells by B Cell Presentation of Antigen

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5269-5276

  Höllsberg, Per ^a,b   Batra, Vandhna ^a   Dressel, Alexander ^a   Hafler, David A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 LIGAND; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN;

ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LINE; CLONAL ANERGY; CYTOTOXICITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD80; B-LYMPHOCYTES; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CLONAL ANERGY; CYTOTOXICITY, IMMUNOLOGIC; GENE EXPRESSION; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 0030589319     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Lamb, J., B. Skidmore, N. Green, J. Chiller, and M. Feldman. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157:1434.
2. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445.
3. Mueller, D., and M. Jenkins. 1995. Molecular mechanisms underlying functional T-cell unresponsiveness. Curr. Opin. Immunol. 7:375.
4. 4: Schwartz, R. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065.
5. Tsuchida, T., K. Parker, R. Turner, H. McFarland, J. Coligan, and W. Biddison. 1994. Autoreactive CD8 T-cell responses to human myelin protein-derived peptides. Proc. Natl. Acad. Sci. USA 91:10859.
6. Guerder, S., and P. Matzinger. 1989. Activation versus tolerance: a decision made by T helper cells. Cold Spring Harbor Symp. Quant. Biol. 54:799.
7. Otten, G., and R. Germain. 1991. Split anergy in a CD8 T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science 251:1228.
8. + T cells. J. Immunol. 151:2355.
9. June, C., J. Bluestone, L. Nadler, and C. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
10. Linsley, P. S., P. M. Wallace, J. Johnson, M. G. Gibsom, J. L. Greene, J. A. Ledbetter, C. Singh, and M. A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257:792.
11. Green, J. M., P. J. Noel, A. I. Sperling, T. L. Walunas, G. S. Gray, J. A. Bluestone, and C. B. Thompson. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1:501.
12. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T-lymphocytes. Cell 77:727.
13. Lindsten, T., C. June, J. Ledbetter, G. Stella, and C. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T-cell activation pathway. Science 244:339.
14. Umlauf, S., B. Beverly, O. Lantz, and R. Schwartz. 1995. Regulation of IL-2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNA are regulated with complex kinetics. Mol. Cell. Biol. 15:3197.
15. Beverly, B., S. M. Kang, M. J. Lenardo, and R. H. Schwartz. 1992. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int. Immunol. 4:661.
16. DeSilva, D. R., K. B. Urdahl, and M. K. Jenkins. 1991. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147:3261.
17. Sloan-Lancaster, J., B. Evavold, and P. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand. Nature 363:156.
18. Sloan-Lancaster, J., B. Evavold, and P. Allen. 1994. Th2 cell clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195.
19. Liu, J., J. Farmer, W. Lane, J. Friedman, I. Weissman, and S. Schreiber. 1991. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807.
20. + T cells. Science 271:1272.
21. + T cells. Science 271:1276.
22. Höllsberg, P., W. E. J. Weber, F. Dangond, V. Batra, A. Sette, and D. A. Hafler. 1995. Differential activation of proliferation and cytotoxicity in human T-cell lymphotrophic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proc. Natl. Acad. Sci. USA 92:4036.
23. Höllsberg, P., L. J. Ausubel, and D. A. Hafler. 1994. Human T cell lymphotrophic virus type I-induced T cell activation: resistance to TGF-β1-induced suppression. J. Immunol. 153:566.
24. Höllsberg, P., K. W. Wucherpfennig, L. J. Ausubel, V. Calvo, B. E. Bierer, and D. A. Hafler. 1992. Characterization of HTLV-I in vivo infected T cell clones: IL-2-independent growth of nontransformed T cells. J. Immunol. 148:3256.
25. Arnold, B., G. Schonrich, and G. Hammerling. 1993. Multiple levels of peripheral tolerance. Immunol. Today 14:12.
26. Guerder, S., J. Meyerhoff, and R. Flavell. 1994. The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen. Immunity 1:155.
27. Bluestone, J. A. 1995. New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2:555.
28. Migata, K., K. Eguchi, Y. Kawabe, T. Tsukada, Y. Ichinose, and S. Nagataki. 1995. Defective TCR-mediated signaling in anergic T cells. J. Immunol. 155: 5083.
29. Mueller, D., L. Chiodetti, P. Bacon, and R. Schwartz. 1991. Clonal anergy blocks the response to IL-4, as well as the production of IL-2, in dual-producing T helper cell clones. J. Immunol. 147:4118.
30. Gajewski, T., D. Lancki, R. Stack, and F. Fitch. 1994. 'Anergy' of Th0 helper T lymphocytes induces downregulation of Th1 characteristics and a transition to a Th2-like phenotype. J. Exp. Med. 179:481.
31. Johnson, J. G., and M. K. Jenkins. 1994. Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction. J. Immunol. 152:429.
32. Tivol, E., F. Borriello, A. Schweitzer, W. Lynch, J. Bluestone, and A. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destraction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
33. Waterhouse, P., J. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. Lee, C. Thompson, H. Griesser, and T. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:985.
34. Walunas, T., D. Lenschow, C. Bakker, P. Linsley, G. Freeman, J. Green, C. Thompson, and J. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
35. Russell, J., C. White, D. Loh, and P. Meleedy-Rey. 1991. Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc. Natl. Acad. Sci. USA 88:2151.
36. Ucker, D., J. Meyers, and P. Obermiller. 1992. Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J. Immunol. 149:1583.
37. Lenardo, M. 1991. Interleukin-2 programs mouse αβ-T lymphocytes for apoptosis. Nature 353:858.