Dicentric breakage at telomere fusions

Genes and Development

Volumn 24, Issue 7, 2010, Pages 720-733

  Pobiega, Sabrina ^a,b   Marcand, Stéphane ^a,b  

^a DIF   (France)

^b CNRS   (France)

Author keywords

Centromere; Dicentric; Karyotype stability; NHEJ; Rap1; Telomere

Indexed keywords

ARTICLE; CENTROMERE; CHROMOSOME; CHROMOSOME BREAKAGE; DICENTRIC CHROMOSOME; MITOSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TELOMERE; GENETICS;

SACCHAROMYCES CEREVISIAE;

CENTROMERE; CHROMOSOME BREAKAGE; CHROMOSOMES, FUNGAL; MITOSIS; SACCHAROMYCES CEREVISIAE; TELOMERE;

EID: 77950495588     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.571510     Document Type: Article

References (69)

1. Aihara H, Huang WM, Ellenberger T. 2007. An interlocked dimer of the protelomerase TelK distorts DNA structure for the formation of hairpin telomeres. Mol Cell 17:901-913. (Pubitemid 47488187)
2. Avarello R, Pedicini A, Caiulo A, Zuffardi O, Fraccaro M. 1992. Evidence for an ancestral alphoid domain on the long arm of human chromosome 2. Hum Genet 89: 247-249.
3. Bae NS, Baumann P. 2007. A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. Mol Cell 26: 323-334. (Pubitemid 46687097)
4. Bajer A. 1964. Cine-micrographic studies on dicentric chromosomes. Chromosoma 15: 630-651.
5. Bateman AJ. 1975. Letter: Simplification of palindromic telomere theory. Nature 253: 379-380.
6. Baxter J, Diffley JF. 2008. Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Mol Cell 30: 790-802. (Pubitemid 351815125)
7. Callebaut I, Malivert L, Fischer A, Mornon JP, Revy P, de Villartay JP. 2006. Cernunnos interacts with the XRCC4 · DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1. J Biol Chem 281: 13857-13860. (Pubitemid 43848307)
8. Capper R, Britt-Compton B, Tankimanova M, Rowson J, Letsolo B, Man S, Haughton M, Baird DM. 2007. The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes & Dev 21: 2495-2508. (Pubitemid 47529377)
9. Celli GB, de Lange T. 2005. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol 7: 712-718. (Pubitemid 40975753)
10. Chan SW, Blackburn EH. 2003. Telomerase and ATM/Tellp protect telomeres from nonhomologous end joining. Mol Cell 11: 1379-1387.
11. Cote AG, Lewis SM. 2008. Mus81 -dependent double-strand DNA breaks at in vivo-generated cruciform structures in S. cerevisiae. Mol Cell 31: 800-812.
12. Daley JM, Palmbos PL, Wu D, Wilson TE. 2005. Nonhomologous end joining in yeast. Annu Rev Genet 39: 431-451.
13. de Lange T. 2009. How to solve the end-protection problem. Science 326: 948-952.
14. Denchi EL, Celli G, de Lange T. 2006. Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes & Dev 20: 2648-2653. (Pubitemid 44498375)
15. Deng Y, Guo X, Ferguson DO, Chang S. 2009. Multiple roles for MRE11 at uncapped telomeres. Nature 460: 914-918.
16. Ferreira MG, Cooper JP. 2001. The fission yeast Tazl protein protects chromosomes from Ku-dependent end-to-end fusions. Mol Cell 7: 55-63.
17. Greider CW, Blackburn EH. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405-413.
18. Grossi S, Bianchi A, Damay P, Shore D. 2001. Telomere formation by rap1p binding site arrays reveals end-specific length regulation requirements and active telomeric recombination. Mol Cell Biol 21: 8117-8128. (Pubitemid 33051801)
19. Haber JE, Thorburn PC, Rogers D. 1984. Meiotic and mitotic behavior of dicentric chromosomes in Saccharomyces cerevisiae. Genetics 106: 185-205.
20. Han F, Gao Z, Birchler JA. 2009. Reactivation of an inactive centromere reveals epigenetic and structural components for centromere specification in maize. Plant Cell 21:1929-1939.
21. Heacock M, Spangler E, Riha K, Puizina J, Shippen DE. 2004. Molecular analysis of telomere fusions in Arabidopsis: Multiple pathways for chromosome end-joining. EMBO J 23: 2304-2313. (Pubitemid 38833239)
22. Hill A, Bloom K. 1987. Genetic manipulation of centromere function. Mol Cell Biol 7: 2397-2405.
23. Hill A, Bloom K. 1989. Acquisition and processing of a conditional dicentric chromosome in Saccharomyces cerevisiae. Mol Cell Biol 9: 1368-1370.
24. IJdo JW, Baldini A, Ward DC, Reeders ST, Wells RA. 1991. Origin of human chromosome 2: An ancestral telomere-telomere fusion. Proc Natl Acad Sci 88: 9051-9055, (Pubitemid 21915566).
25. Ishii K, Ogiyama Y, Chikashige Y, Soejima S, Masuda F, Kakuma T, Hiraoka Y, Takahashi K. 2008. Heterochromatin integrity affects chromosome reorganization after centromere dysfunction. Science 321: 1088-1091.
26. Jannink G, Duplantier B, Sikorav JL. 1996. Forces on chromosomal DNA during anaphase. Biophys J 71: 451-465.
27. Katz W, Weinstein B, Solomon F. 1990. Regulation of tubulin levels and microtubule assembly in Saccharomyces cerevisiae: Consequences of altered tubulin gene copy number. Mol Cell Biol 10: 5286-5294. (Pubitemid 20293870)
28. Konishi A, de Lange T. 2008. Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNAbinding domain of TRF2. Genes & Dev 22: 1221-1230. (Pubitemid 351656580)
29. Koshland D, Rutledge L, Fitzgerald-Hayes M, Hartwell LH. 1987. A genetic analysis of dicentric minichromosomes in Saccharomyces cerevisiae. Cell 48: 801-812.
30. Kramer KM, Brock JA, Bloom K, Moore JK, Haber JE. 1994. Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events. Mol Cell Biol 14:1293-1301. (Pubitemid 24036579)
31. Lalande M, Noolandi J, Turmel C, Rousseau J, Slater GW. 1987. Pulsed-field electrophoresis: Application of a computer model to the separation of large DNA molecules. Proc Natl Acad Sci 84: 8011-8015.
32. Lejeune J, Dutrillaux B, Rethore MO, Prieur M. 1973. [Comparison of the structure of chromatids of Homo sapiens and Pan troglodytes (author's transl)]. Chromosoma 43: 423-444.
33. Lo AW, Sprung CN, Fouladi B, Pedram M, Sabatier L, Ricoul M, Reynolds GE, Murnane JP. 2002. Chromosome instability as a result of double-strand breaks near telomeres in mouse embryonic stem cells. Mol Cell Biol 22: 4836-4850. (Pubitemid 34620418)
34. Lobachev KS, Gordenin DA, Resnick MA. 2002. The Mre11 complex is required for repair of hairpin-capped doublestrand breaks and prevention of chromosome rearrangements. Cell 108: 183-193.
35. Lobachev KS, Rattray A, Narayanan V. 2007. Hairpin- and cruciform-mediated chromosome breakage: Causes and consequences in eukaryotic cells. Front Biosci 12: 4208-4220.
36. Longtine MS, McKenzie A III. Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953-961. (Pubitemid 28328000)
37. Louis EJ, Haber JE. 1992. The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics 131: 559-574.
38. Lowden MR, Meier B, Lee TW, Hall J, Ahmed S. 2008. End joining at Caenorhabditis elegans telomeres. Genetics 180: 741-754.
39. Lydeard JR, Jain S, Yamaguchi M, Haber JE. 2007. Break-induced replication and telomerase-independent telomere maintenance require Pol32. Nature 448: 820-823. (Pubitemid 47266343)
40. Mann C, Davis RW. 1983. Instability of dicentric plasmids in yeast. Proc Natl Acad Sci 80: 228-232.
41. Marcand S, Pardo B, Gratias A, Cahun S, Callebaut I. 2008. Multiple pathways inhibit NHEJ at telomeres. Genes & Dev 22: 1153-1158. (Pubitemid 351656575)
42. Marko JF. 2008. Micromechanical studies of mitotic chromosomes. Chromosome Res 16: 469-497.
43. McClintock B. 1941. The stability of broken ends of chromosomes in Zea mays. Genetics 26: 234-282.
44. McClintock B. 1942. The fusion of broken ends of chromosomes following nuclear fusion. Proc Natl Acad Sci 28: 458-463.
45. Mendoza M, Norden C, Durrer K, Rauter H, Uhlmann F, Barrai Y. 2009. A mechanism for chromosome segregation sensing by the NoCut checkpoint. Nat Cell Biol 11: 477-483.
46. Mieczkowski PA, Mieczkowska JO, Dominska M, Petes TD. 2003. Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. Proc Natl Acad Sci 100: 10854-10859.
47. Miller KM, Ferreira MG, Cooper JP. 2005. Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres. EMBO J 24: 3128-3135.
48. Miller KM, Rog O, Cooper JP. 2006. Semi-conservative DNA replication through telomeres requires Taz1. Nature 440: 824-828.
49. Murray AW, Claus TE, Szostak JW. 1988. Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae. Mol Cell Biol 8: 4642-4650.
50. Norden C, Mendoza M, Dobbelaere J, Kotwaliwale CV, Biggins S, Barrai Y. 2006. The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage. Cell 125: 85-98.
51. Paek AL, Kaochar S, Jones H, Elezaby A, Shanks L, Weinert T. 2009. Fusion of nearby inverted repeats by a replicationbased mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast. Genes & Dev 23: 2861-2875.
52. Pardo B, Marcand S. 2005. Rap1 prevents telomere fusions by nonhomologous end joining. EMBO J 24: 3117-3127. (Pubitemid 41486347)
53. Pennaneach V, Kolodner RD. 2009. Stabilization of dicentric translocations through secondary rearrangements mediated by multiple mechanisms in S. cerevisiae. PLoS One 4: e6389. doi:10.1371/journal.pone.0006389.
54. Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS. 2009. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat Struct Mol Biol 16: 819-824.
55. Riha K, Heacock ML, Shippen DE. 2006. The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology. Annu Rev Genet 40: 237-277. (Pubitemid 44956786)
56. Rog O, Miller KM, Ferreira MG, Cooper JP. 2009. Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres. Mol Cell 33: 559-569.
57. Sarthy J, Bae NS, Scrafford J, Baumann P. 2009, Human RAP1 inhibits non-homologous end joining at telomeres. EMBO J 28: 3390-3399.
58. Shore D, Bianchi A. 2009. Telomere length regulation: Coupling DNA end processing to feedback regulation of telomerase. EMBO J 28: 2309-2322.
59. Smith GR. 2008. Meeting DNA palindromes head-to-head. Genes &. Dev 22: 2612-2620.
60. Smith CE, Llorente B, Symington LS. 2007. Template switching during break-induced replication. Nature 447: 102-105.
61. Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T. 2002. DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2. Curr Biol 12: 1635-1644. (Pubitemid 35161916)
62. Surosky RT, Tye BK. 1985. Resolution of dicentric chromosomes by Ty-mediated recombination in yeast. Genetics 110: 397-419.
63. Szostak JW. 1983. Replication and resolution of telomeres in yeast. Cold Spring Harb Symp Quant Biol 47: 1187-1194,
64. Tanaka K, Mukae N, Dewar H, van Breugel M, James EK, Prescott AR, Antony C, Tanaka TU. 2005. Molecular mechanisms of kinetochore capture by spindle microtubules. Nature 434: 987-994. (Pubitemid 40586041)
65. Therizols P, Duong T, Dujon B, Zimmer C, Fabre E. 2010. Chromosome arm length and nuclear constraints determine the dynamic relationship of yeast subtelomeres. Proc Natl Acad Sci 107: 2025-2030.
66. Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, Dunham MJ, Amon A. 2007. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science 317: 916-924. (Pubitemid 47301313)
67. van Steensel B, Smogorzewska A, de Lange T. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell 92: 401-413. (Pubitemid 28093017)
68. Walmsley RM, Szostak JW, Petes TD. 1983. Is there left-handed DNA at the ends of yeast chromosomes? Nature 302: 84-86. (Pubitemid 13138485)
69. Xie A, Kwok A, Scully R. 2009. Role of mammalian Mre11 in classical and alternative nonhomologous end joining. Nat Struct Mol Biol 16: 814-818.