Shotgun approach based comparative proteomic analysis of levo-tetrahydropalmatine-induced apoptosis in hepatocytes

Toxicology Letters

Volumn 194, Issue 1-2, 2010, Pages 8-15

  Wang, Chen ^a,b,c   Zhou, Jiangrui ^a   Wang, Shuowen ^a,c   Ye, Mingliang ^b   Fan, Guorong ^a,c   Zou, Hanfa ^b   Jiang, Chunlei ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

Author keywords

2D nano LC; Proteomics; Tetrahydropalmatine; Toxicity

Indexed keywords

CASPASE 3; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; TETRAHYDROPALMATINE; ANALGESIC AGENT; BERBERINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TETRALIN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DOSE RESPONSE; DRUG DOSE COMPARISON; ENZYME REGULATION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER TOXICITY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEIC ACID METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TOXIC HEPATITIS; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECT; METABOLISM; METHODOLOGY; PATHOLOGY; TANDEM MASS SPECTROMETRY;

MAMMALIA; MUS;

ANALGESICS; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BERBERINE ALKALOIDS; CASPASE 3; CELL LINE; CHROMATOGRAPHY, LIQUID; HEPATOCYTES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAP KINASE KINASE 2; MICE; MICE, INBRED BALB C; PROTEIN-SERINE-THREONINE KINASES; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-BCL-2; TANDEM MASS SPECTROMETRY; TETRAHYDRONAPHTHALENES;

EID: 77950491441     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.01.014     Document Type: Article

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