Suppression of human cytochrome P450 aromatase activity by monoclonal and recombinant antibody fragments and identification of a stable antigenic complex

Journal of Steroid Biochemistry and Molecular Biology

Volumn 88, Issue 3, 2004, Pages 235-245

  Lala, Puloma ^a,b   Higashiyama, Tadayoshi ^a   Erman, Mary ^a   Griswold, Jennifer ^a   Wagner, Traci ^a   Osawa, Yoshio ^a   Ghosh, Debashis ^a,b  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

17HSD1; ES; human 17 hydroxysteroid dehydrogenase type 1; human cytochrome P450 aromatase; human estrone dehydroepiandrosterone sulfatase; MAb; monoclonal antibody; P450arom; variable domain of MAb heavy chain; variable domain of MAb light chain; VH; VL

Indexed keywords

ANTIGEN; AROMATASE; CYTOCHROME P450; DIMER; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MAB3 2C2; RECOMBINANT ANTIBODY; RECOMBINANT SINGLE CHAIN ANTIBODY FRAGMENT; UNCLASSIFIED DRUG;

ANTIBODY ENGINEERING; ANTIGEN ANTIBODY COMPLEX; ARTICLE; COMPLEMENTARITY DETERMINING REGION; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME REPRESSION; ENZYME STRUCTURE; ESCHERICHIA COLI; HUMAN; IC 50; PRECIPITATION; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS; AROMATASE; AROMATASE INHIBITORS; CLONING, MOLECULAR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

EID: 2342436397     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2003.12.010     Document Type: Article

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