A three-dimensional model of CYP19 aromatase for structure-based drug design

Journal of Steroid Biochemistry and Molecular Biology

Volumn 105, Issue 1-5, 2007, Pages 63-70

  Karkola, Sampo ^a   Höltje, Hans Dieter ^b   Wähälä, Kristiina ^a  

^a Faculty of Behavioural Sciences   (Finland)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Aromatase; Breast cancer; CYP2C5; CYP450; Homology modeling; Molecular dynamics; Structure based drug design

Indexed keywords

ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITOR; ESTRADIOL; ESTROGEN RECEPTOR; ESTRONE;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESTROGEN BINDING; ESTROGEN SYNTHESIS; HORMONE RECEPTOR INTERACTION; MOLECULAR DYNAMICS; MOLECULAR MODEL;

AMINO ACID SEQUENCE; ANIMALS; AROMATASE; DRUG DESIGN; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RABBITS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 34547692960     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2006.11.023     Document Type: Article

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