2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 494-497

  Olepu, Srinivas ^a   Suryadevara, Praveen Kumar ^a   Rivas, Kasey ^a   Yokoyama, Kohei ^a   Verlinde, Christophe L M J ^a   Chakrabarti, Debopam ^b   Van Voorhis, Wesley C ^a   Gelb, Michael H ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

Anti malarials; Drug discovery; Malaria; P. falciparum; Protein farnesyltransferase; Rational drug design

Indexed keywords

2 OXOTETRAHYDRO 1,8 NAPHTHYRIDINE DERIVATIVE; ANTIMALARIAL AGENT; NAPHTHYRIDINE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; QUINOLINE DERIVATIVE; TETRAHYDROQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; INHIBITION KINETICS; METABOLIC REGULATION; NONHUMAN; PARASITE IDENTIFICATION; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTIMALARIALS; DRUG DESIGN; ENZYME INHIBITORS; NAPHTHYRIDINES; PLASMODIUM FALCIPARUM; RATS;

MAMMALIA; PLASMODIUM FALCIPARUM;

EID: 38149038655     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.104     Document Type: Article

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