Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola

Malaria Journal

Volumn 5, Issue , 2006, Pages

  Pimentel, Sónia ^a   Nogueira, Fátima ^a   Benchimol, Carla ^b   Quinhentos, Vatúsia ^b   Bom, Joana ^a   Varandas, Luís ^a   Do Rosário, Virgílio ^a   Bernardino, Luís ^b  

^a INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^b Hospital Militar Central de Luanda   (Angola)

Author keywords

[No Author keywords available]

Indexed keywords

ATOVAQUONE PLUS PROGUANIL; CYTOCHROME B;

ANGOLA; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; ARTICLE; BLOOD SAMPLING; CHILD; CODON; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; GENE IDENTIFICATION; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALARIA; PLASMODIUM FALCIPARUM; POINT MUTATION; POLYMERASE CHAIN REACTION; PRESCRIPTION; PREVALENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TREATMENT FAILURE;

ANGOLA; ANIMALS; ANTIMALARIALS; ATOVAQUONE; CYTOCHROMES B; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE; HUMANS; MALARIA, FALCIPARUM; MUTATION; NAPHTHOQUINONES; PLASMODIUM FALCIPARUM; POLYMORPHISM, GENETIC; PROGUANIL; TRAVEL;

EID: 33746322417     PISSN: 14752875     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-5-30     Document Type: Article

References (30)

1. World Tourism Organization: [http://www.world-tourism.org].
2. Muentener P, Schlagenhauf P, Steffen R: Imported malaria (1985-95): trends and perspectives. Bull WHO 1999, 77:560-566.
3. World Health Organization: The use of antimalarial drugs. Report of an informal consultation . 13-17 November 2001 (document WHO/CDS/RBM/2001.33)
4. Jelinek T, Schulte C, Behrens R, Grobusch M, Coulaud J, Bisoffi Z, Matteelli A, Clerinx J, Corachán M, Puente S, Gjorup I, Harms G, Kollaritsch H, Kotlowski A, Björkmann A, Delmont JP, Knobloch J, Nielsen L, Cuadros J, Hatz C, Beran J, Schmid M, Schulze M, Lopez-Velez R, Fleischer K, Kapaun A, McWhinney P, Kern P, Atouguia J, Fry G, da Cunha S, Boecken G: Imported falciparum malaria in Europe: sentinel surveillance data from the European Network on Surveillance of Imported Infectious Diseases. Clin Infect Dis 2002, 34:572-576.
5. Leder K, Black J, O'Brin D, Greenwood Z, Kain K, Brown G, Torresi J: Malaria in travelers: a review of the Geosentinel Surveillance Network. Clin Infect Dis 2004, 39:1104-1112.
6. Shah S, Filler S, Causer L, Rowe A, Bloland P, Barber A, Roberts J, Desai M, Parise M, Steketee R: Malaria Surveillance - United States, 2002. Surveil Summs 2004:21-34.
7. Jelinek T, Blüml A, Löscher T, Nothdurft H: Assessing the incidence of infection with Plasmodium falciparum among international travelers. Am J Trop Med Hyg 1993, 59:35-37.
8. Legros F, Danis M: Surveillance of malaria in European Union countries. Eurosurveillance 1998, 3:45-54.
9. Kain KC, Harrington MA, Tennyson S, Keystone JS: Imported malaria: prospective analysis of problems in diagnosis and management. Clin Infect Dis 1998, 27:142-149.
10. Fry M, Pudney M: Site of action of the antimalarial hydroxynaphthoquinone, 2 - [trans - 4 (4′ - chlorophenyl) cyclohexyl] - 3 - hydroxy-1, 4-naphthoquinone (566C80). Biochem Pharmacol 1992, 43:1545-1553.
11. Vaidya AB, Lashgari MS, Pologe LG, Morrisey J: Structural features of Plasmodium cytohrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinones. Mol Biochem Parasitol 1993, 58:33-42.
12. Srivastava IK, Rottenberg H, Vaidya AB: Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in malaria parasites. J Biol Chem 1997, 272:3961-3966.
13. Hudson AT: Atovaquone - a novel broad-spectrum anti-infective drug. Parasitol Today 1993, 9:66-68.
14. Srivastava IK, Vaidya AB: A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother 1999, 43:1334-1339.
15. Shanks G, Gordon D, Klotz F, Aleman G, Oloo A, Sadie D, Scott T: Efficacy and safety of atovaquone-proguanil as suppressive prophylaxis for Plasmodium falciparum malaria. Clin Infect Dis 1998, 27:494-499.
16. Shapiro TA, Ranasinha CD, Kumar N, Barditch-Crovo P: Prophylatic activity of atovaquone against Plasmodium falciparum in humans. Am J Trop Med Hyg 1999, 60:831-836.
17. Berman JD, Nielsen R, Chulay JD, Dowler M, Kain K, Kester K, Williams J, Whelen A, Shmuklarsky : Causal prophylactic efficacy of atovaquone-proguanil (Malarone) in a human challenge model. Trans R Soc Trop Med Hyg 2001, 95:429-432.
18. McKeage K, Scott L: Atovaquone/Proguanil: A review of its use for the prophylaxis of Plasmodium falciparum malaria. Drugs 2003, 63:597-623.
19. Petersen E: The safety of atovaquone/proguanil in long-term malaria prophylaxis of Plasmodium falciparum malaria. J Travel Med 2003:13-15.
20. World Health Organization - International Travel and Health: [http://www.who.int/ith/en].
21. Kain K: Current status and replies to frequently posed questions on atovaquone plus proguanil (Malarone® ) for the prevention of malaria. Biodrugs 2003:23-28.
22. Petersen E: Malaria chemoprophylaxis: when should we use it and what are the options? Expert Rev Anti Infect Ther 2004, 2:119-132.
23. Fivelman QL, Butcher GA, Adagu IS, Warhurst DC, Pasvol G: Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria. Malar J 2002, 1:1.
24. Schwöbel B, Alifrangis M, Salanti A, Jelinek T: Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker. Malar J 2003, 2:5.
25. Schwartz E, Bujanover S, Kain KC: Genetic confirmation of atovaquone-proguanil resistant Plasmodium falciparum malaria acquired by a non-immune traveller to East Africa. Clin Infect Dis 2003, 37:450-451.
26. Färnert A, Lindberg J, Gil JP, Swedberg G, Berqvist Y, Thapar M, Lindegardh N, Berezcky S, Björkman A: Evidence of Plasmodium falciparum malaria resistance to atovaquone and proguanil hydrochloride: case reports. BMJ 2003, 326:628-629.
27. Wichman O, Muehlberger N, Jelinek T, Alifrangis M, Peyerl-Hoffmann G, Mühlen M, Grobusch M, Gascon J, Matteelli A, Laferl H, Bisoffi Z, Ehrhardt S, Cuadros J, Hatz C, Gjørup I, McWhinney P, Beran J, Cunha S, Schulze M, Kollaritsch H, Kern P, Fry G, Richter J: Screening for mutations related to atovaquone-proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe. J Infect Dis 2004, 190:1541-1546.
28. Singh B, Cox-Singh J, Miller AO, Abdullah MS, Snounou G, Rahman H: Detection of malaria in Malaysia by nested polymerase chain reaction amplification of dried blood spots on filter papers. Trans R Soc Trop Med Hyg 1996, 90:519-521.
29. Gil JP, Nogueira F, Strömberg-Nörklit J, Lindberg J, Carrolo M, Casimiro C, Lopes D, Arez A, Cravo P, Rosário V: Detection of atovaquone and Malarone® resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb). Mol Cel Probes 2003, 17:85-89.
30. Muehlen M, Schreiber J, Ehrhardt S, Otchwemah R, Jelinek T, Bienzle U, Mockenhaupt F: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana. Trop Med Int Health 2004, 9:361-363.