Silencing of the insulin receptor isoform A favors formation of type 1 insulin-like growth factor receptor (IGF-IR) homodimers and enhances ligand-induced IGF-IR activation and viability of human colon carcinoma cells

Endocrinology

Volumn 151, Issue 4, 2010, Pages 1418-1427

  Brierley, G V ^a,b   Macaulay, S L ^b   Forbes, B E ^a   Wallace, J C ^a   Cosgrove, Leah J ^b   Macaulay, V M ^c  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b CSIRO   (Australia)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; INSULIN RECEPTOR A; SMALL INTERFERING RNA; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL ACTIVATION; CELL VIABILITY; COLON CARCINOMA; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION;

BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENE SILENCING; HUMANS; IMMUNOPRECIPITATION; INDANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 77950226030     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-1006     Document Type: Article

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