The c-Jun N-terminal kinase (JNK) inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats

Neuropathology and Applied Neurobiology

Volumn 36, Issue 3, 2010, Pages 211-224

  Liu, J R ^a,c   Zhao, Y ^a   Patzer, A ^a   Staak, N ^a   Boehm, R ^a   Deuschl, G ^a   Culman, J ^a   Bonny, C ^d   Herdegen, T ^a   Eschenfelder, C ^a,b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c ZHEJIANG UNIVERSITY   (China)

^d Xigen SA   (Switzerland)

Author keywords

C Jun N terminal kinase; Cerebral ischaemia; Hyperbaric oxygen; Middle cerebral artery; Neurodegeneration; Neuroprotection

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXYGEN; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; XG 102;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN SLICE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; HYPERBARIC OXYGEN; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOTHERAPY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

AGING; ANIMALS; BRAIN; BRAIN EDEMA; BRAIN ISCHEMIA; ENZYME INHIBITORS; HYPERBARIC OXYGENATION; INFARCTION, MIDDLE CEREBRAL ARTERY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; NEUROPROTECTIVE AGENTS; PEPTIDES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 77950223125     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2009.01047.x     Document Type: Article

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