Presence of specific 11C-meta-Hydroxyephedrine retention in heart, lung, pancreas, and brown adipose tissue

Journal of Nuclear Medicine

Volumn 48, Issue 10, 2007, Pages 1733-1740

  Thackeray, James T ^a,b   Beanlands, Rob S ^a,b   DaSilva, Jean N ^a,b  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Competition with norepinephrine; HPLC column switch system; Norepinephrine transporter uptake 1; Sympathetic nervous system function

Indexed keywords

3 HYDROXYEPHEDRINE; CARBON 11; NORADRENALIN; 3-HYDROXYEPHEDRINE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; EPHEDRINE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DRUG RETENTION; DRUG TISSUE LEVEL; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LUNG; MALE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; RADIOACTIVITY; RAT; ANIMAL; ANTIBODY SPECIFICITY; HEART MUSCLE; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ADIPOSE TISSUE, BROWN; ANIMALS; EPHEDRINE; HEART; LUNG; MALE; METABOLIC CLEARANCE RATE; MYOCARDIUM; ORGAN SPECIFICITY; PANCREAS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 35348918857     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.043570     Document Type: Article

References (40)

1. Esler M, Jennings G, Lambert G, Meredith I, Horne M, Eisenhofer G. Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions. Physiol Rev. 1990;70:963-985.
2. Raffel DM, Wieland DM. Assessment of cardiac sympathetic nerve integrity with positron emission tomography. Nucl Med Biol. 2001;28:541-559.
3. Collins S, Surwit RS. The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog Horm Res. 2001;56:309-328.
4. Noble MD, Liddle RA. Neurohormonal control of exocrine pancreatic secretion. Curr Opin Gastroenterol. 2005;21:531-537.
5. Bulow HP, Stahl F, Lauer B, et al. Alterations of myocardial presynaptic sympathetic innervation in patients with multi-vessel coronary artery disease but without history of myocardial infarction. Nucl Med Commun. 2003;24:233-239.
6. Meredith IT, Broughton A, Jennings GL, Esler MD. Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias. N Engl J Med. 1991;325:618-624.
7. Bachman ES, Dhillon H, Zhang CY, et al. βAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002;297:843-845.
8. Stevens MJ, Raffel DM, Allman KC, Schwaiger M, Wieland DM. Regression and progression of cardiac sympathetic dysinnervation complicating diabetes: an assessment by C-11 hydroxyephedrine and positron emission tomography. Metabolism. 1999;48:92-101.
9. Rosenspire KC, Haka MS, Van Dort ME, et al. Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging. J Nucl Med. 1990;31:1328-1334.
10. Link JM, Stratton JR, Levy W, et al. PET measures of pre- and post-synaptic cardiac beta adrenergic function. Nucl Med Biol. 2003;30:795-803.
11. 11C]m-hydroxyephedrine in the rat. Nucl Med Biol. 1997;24:417-424.
12. 11C-meta-hydroxyephedrine retention on norepinephrine transporter density. J Nucl Med. 2006;47:1490-1496.
13. Ungerer M, Hartmann F, Karoglan M, et al. Regional in vivo and in vitro characterization of autonomic innervation in cardiomyopathic human heart. Circulation. 1998;97:174-180.
14. Allman KC, Wieland DM, Muzik O, Degrado TR, Wolfe ER Jr, Schwaiger M. Carbon-11 hydroxyephedrine with positron emission tomography for serial assessment of cardiac adrenergic neuronal function after acute myocardial infarction in humans. J Am Coll Cardiol. 1993;22:368-375.
15. DeGrado TR, Hutchins GD, Toorongian SA, Wieland DM, Schwaiger M. Myocardial kinetics of carbon-11-meta-hydroxyephedrine: retention mechanisms and effects of norepinephrine. J Nucl Med. 1993;34:1287-1293.
16. 11C]-metahydroxyephedrine and metabolites in plasma. J Chromatogr B Biomed Sci Appl. 1997;693:31-41.
17. 11C]hydroxyephedrine, a specific tracer for sympathetic nerve endings, and its functional correlates in congestive heart failure. Am J Cardiol. 1999;84:568-574.
18. Kies P, Wichter T, Schafers M, et al. Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Circulation. 2004;110:3017-3022.
19. 11C]rolipram for PET imaging of phosphodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats. Nucl Med Biol. 2001;28:347-358.
20. Wong DT, Threlkeld PG, Best KL, Bymaster FP. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J Pharmacol Exp Ther. 1982;222:61-65.
21. 11C]rolipram in rat brain, lung and heart. Life Sci. 2006;79:356-364.
22. Laycock SK, Kane KA, McMurray J, Parratt JR. Captopril and norepinephrine-induced hypertrophy and haemodynamics in rats. J Cardiovasc Pharmacol. 1996;27:667-672.
23. Hilton J, Yokoi F, Dannals RF, Ravert HT, Szabo Z, Wong DF. Column-switching HPLC for the analysis of plasma in PET imaging studies. Nucl Med Biol. 2000;27:627-630.
24. Mardon K, Montagne O, Elbaz N, et al. Uptake-1 carrier downregulates in parallel with the beta-adrenergic receptor desensitization in rat hearts chronically exposed to high levels of circulating norepinephrine: implications for cardiac neuroimaging in human cardiomyopathies. J Nucl Med. 2003;44:1459-1466.
25. Kopin IJ, Gordon EK. Origin of norepinephrine in the heart [letter]. Nature. 1963;199:1289.
26. Liang CS, Fan TH, Sullebarger JT, Sakamoto S. Decreased adrenergic neuronal uptake activity in experimental right heart failure: a chamber-specific contributor to beta-adrenoceptor downregulation. J Clin Invest. 1989;84:1267-1275.
27. Ding YS, Lin KS, Garza V, et al. Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs. Synapse. 2003;50:345-352.
28. Raasmaja A, York DA. Alpha 1- and beta-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/fa) Zucker rats: effects of cold-acclimation, sucrose feeding and adrenalectomy. Biochem J. 1988;249:831-838.
29. King VL, Dwoskin LP, Cassis LA. Cold exposure regulates the norepinephrine uptake transporter in rat brown adipose tissue. Am J Physiol. 1999;276:R143-R151.
30. Yi E, Smith TG, Baker RC, Love JA. Catecholamines and 5-hydroxytryptamine in tissues of the rabbit exocrine pancreas. Pancreas. 2004;29:218-224.
31. Birkenfeld AL, Schroeder C, Boschmann M, et al. Paradoxical effect of sibutramine on autonomic cardiovascular regulation. Circulation. 2002;106:2459-2465.
32. Routledge C, Marsden CA. Comparison of the effects of selected drugs on the release of hypothalamic adrenaline and noradrenaline measured in vivo. Brain Res. 1987;426:103-111.
33. Keck PE Jr, Carter WP, Nierenberg AA, Cooper TB, Potter WZ, Rothschild AJ. Acute cardiovascular effects of tranylcypromine: correlation with plasma drug, metabolite, norepinephrine, and MHPG levels. J Clin Psychiatry. 1991;52:250-254.
34. Fillenz M, Stanford SC. Vesicular noradrenaline stores in peripheral nerves of the rat and their modification by tranylcypromine. Br J Pharmacol. 1981;73:401-404.
35. 3H]mazindol to cardiac norepinephrine transporters: kinetic and equilibrium studies. Naunyn Schmiedebergs Arch Pharmacol. 2004;370:9-16.
36. Pop-Busui R, Kirkwood I, Schmid H, et al. Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction. J Am Coll Cardiol. 2004;44:2368-2374.
37. Shulkin BL, Wieland DM, Schwaiger M, et al. PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma. J Nucl Med. 1992;33:1125-1131.
38. 11C]meta- Hydroxyephedrine positron emission tomography in Parkinson's disease and multiple system atrophy. Eur J Nucl Med Mol Imaging. 2003;30:127-131.
39. 18F]4- fluorobenzyltrozamicol. Eur J Nucl Med Mol Imaging. 2004;31:258-260.
40. 18F-FDG PET/CT. J Nucl Med. 2003;44:170-176.