Synthesis and evaluation of novel benzothiazole derivatives based on the bithiophene structure as potential radiotracers for β-amyloid plaques in Alzheimer's disease

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2777-2784

  Cui, Meng Chao ^a   Li, Zi Jing ^a   Tang, Rui Kun ^a   Liu, Bo Li ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Amyloid; Alzheimer's disease; Autoradiography; Binding assay; Imaging agent

Indexed keywords

2 (2,2' BITHIOPHEN 5 YL) 6 IODOBENZO[D]THIAZOLE I 125; 2 (5' IODO 2,2' BITHIOPHEN 5 YL) 6 METHOXYBENZO[D]THIAZOLE I 125; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BENZOTHIAZOLE DERIVATIVE; THIOPHENE DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; FLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; IODODESTANNYLATION; MOUSE; NONHUMAN; PROTEIN AGGREGATION; RADIOIODINATION; REACTION ANALYSIS; SENILE PLAQUE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; AUTORADIOGRAPHY; BENZOTHIAZOLES; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; INJECTIONS, INTRAVENOUS; IODINE RADIOISOTOPES; LIGANDS; MICE; MICE, TRANSGENIC; RADIOPHARMACEUTICALS; SENILE PLAQUES; SOLUBILITY; THIOPHENES; TISSUE DISTRIBUTION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 77950057495     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.002     Document Type: Article

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