Design and synthesis of substrate-mimic inhibitors of mycothiol-S-conjugate amidase from Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 2, 2007, Pages 444-447

  Metaferia, Belhu B ^a   Ray, Satyajit ^a   Smith, Jeremy A ^a   Bewley, Carole A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Mycobacteria; Mycothiol bimane; Myo d inositol; Polymer supported triphenyl phosphine; Pseudodisaccharide; Quinic acid

Indexed keywords

AMIDASE; BACTERIAL ENZYME; ENZYME INHIBITOR;

ARTICLE; DETOXIFICATION; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; GLYCOSYLATION; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SCREENING; STAUDINGER REACTION; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; DRUG DESIGN; ENZYME INHIBITORS; GLYCOPEPTIDES; GLYCOSYLATION; INOSITOL; MYCOBACTERIUM TUBERCULOSIS; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 33846112198     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.031     Document Type: Article

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