BmKCT toxin inhibits glioma proliferation and tumor metastasis

Cancer Letters

Volumn 291, Issue 2, 2010, Pages 158-166

  Fan, Shaozhong ^a   Sun, Zhengbo ^a   Jiang, Dahe ^a   Dai, Chao ^a   Ma, Yibao ^a   Zhao, Zhenhuan ^a   Liu, Hui ^a   Wu, Yingliang ^a   Cao, Zhijian ^a   Li, Wenxin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

BmKCT; Gliomas; In vivo; Metastasis; Proliferation; Scorpion toxin; Targeting

Indexed keywords

BUTHUS MARTENSII KARSCH CHLOROTOXIN LIKE TOXIN; IODINE 131; SCORPION VENOM; TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER DIAGNOSIS; CANCER INHIBITION; CANCER MODEL; CANCER THERAPY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CONJUGATION; FEMALE; GLIOMA; GLIOMA CELL; IN VIVO STUDY; ISOTOPE LABELING; METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CELL DIVISION; CELL LINE, TUMOR; CLONING, MOLECULAR; FEMALE; GENE AMPLIFICATION; GLIOMA; GLUTATHIONE TRANSFERASE; NEOPLASM METASTASIS; RATS; RATS, SPRAGUE-DAWLEY; SCORPION VENOMS; SCORPIONS; SODIUM RADIOISOTOPES; TISSUE DISTRIBUTION;

RATTUS; SCORPIONES;

EID: 77950021940     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.10.011     Document Type: Article

References (49)

1. Hatta S., Sakamoto J., and Horio Y. Ion channels and diseases. Med. Electron Microsc. 35 (2002) 117-126
2. Nguyen T.P., Wang D.W., Rhodes T.H., and George Jr. A.L. Divergent biophysical defects caused by mutant sodium channels in dilated cardiomyopathy with arrhythmia. Circ. Res. 102 (2008) 364-371
3. Zucca C., Redaelli F., Epifanio R., Zanotta N., Romeo A., Lodi M., Veggiotti P., Airoldi G., Panzeri C., Romaniello R., De Polo G., Bonanni P., Cardinali S., Baschirotto C., Martorell L., Borgatti R., Bresolin N., and Bassi M.T. Cryptogenic epileptic syndromes related to SCN1A: twelve novel mutations identified. Arch. Neurol. 65 (2008) 489-494
4. Sokolov S., Scheuer T., and Catterall W.A. Gating pore current in an inherited ion channelopathy. Nature 446 (2007) 76-78
5. Felipe A., Vicente R., Villalonga N., Roura-Ferrer M., Martinez-Marmol R., Sole L., Ferreres J.C., and Condom E. Potassium channels: new targets in cancer therapy. Cancer Detect. Prev. 30 (2006) 375-385
6. Soroceanu L., Manning Jr. T.J., and Sontheimer H. Modulation of glioma cell migration and invasion using Cl(-) and K(+) ion channel blockers. J. Neurosci. 19 (1999) 5942-5954
7. Eder C. Regulation of microglial behavior by ion channel activity. J. Neurosci. Res. 81 (2005) 314-321
8. Camerino D.C., Tricarico D., and Desaphy J.F. Ion channel pharmacology. Neurotherapeutics 4 (2007) 184-198
9. Lightbown I.D., Johnson M., Davis A., Leaney J., and Leishman D.J. Towards automation of a valuable preclinical cardiac safety pharmacology assay: evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro. J. Pharmacol. Toxicol. Methods 56 (2007) 194-202
10. Greene J.G., Porter R.H., and Greenamyre J.T. ARL-15896, a novel N-methyl-d-aspartate receptor ion channel antagonist: neuroprotection against mitochondrial metabolic toxicity and regional pharmacology. Exp. Neurol. 137 (1996) 66-72
11. Lewis R.J., and Garcia M.L. Therapeutic potential of venom peptides. Nat. Rev. Drug. Discov. 2 (2003) 790-802
12. Estrada G., Villegas E., and Corzo G. Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs. Nat. Prod. Rep. 24 (2007) 145-161
13. Terlau H., and Olivera B.M. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol. Rev. 84 (2004) 41-68
14. Trans Molecular receives FDA approval for 131-I-TM-601 IND application. Expert Rev. Anticancer Ther. 2 (2002) 139.
15. MacKinnon R., and Miller C. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science 245 (1989) 1382-1385
16. Zhijian C., Feng L., Yingliang W., Xin M., and Wenxin L. Genetic mechanisms of scorpion venom peptide diversification. Toxicon 47 (2006) 348-355
17. Goudet C., Chi C.W., and Tytgat J. An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon 40 (2002) 1239-1258
18. Prevarskaya N., Skryma R., Bidaux G., Flourakis M., and Shuba Y. Ion channels in death and differentiation of prostate cancer cells. Cell Death Differ. 14 (2007) 1295-1304
19. Roger S., Potier M., Vandier C., Besson P., and Le Guennec J.Y. Voltage-gated sodium channels: new targets in cancer therapy?. Curr. Pharm. Des. 12 (2006) 3681-3695
20. Le Guennec J.Y., Ouadid-Ahidouch H., Soriani O., Besson P., Ahidouch A., and Vandier C. Voltage-gated ion channels, new targets in anti-cancer research. Recent Patents Anticancer Drug Discov. 2 (2007) 189-202
21. Schonherr R. Clinical relevance of ion channels for diagnosis and therapy of cancer. J. Membr. Biol. 205 (2005) 175-184
22. Mao J., Chen L., Xu B., Wang L., Li H., Guo J., Li W., Nie S., Jacob T.J., and Wang L. Suppression of ClC-3 channel expression reduces migration of nasopharyngeal carcinoma cells. Biochem. Pharmacol. 75 (2008) 1706-1716
23. Mamelak A.N., and Jacoby D.B. Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601). Expert Opin. Drug Deliv. 4 (2007) 175-186
24. Liu T., Pang X.Y., Jiang F., Bai Z.T., and Ji Y.H. Anti-nociceptive effects induced by intrathecal injection of BmK AS, a polypeptide from the venom of Chinese-scorpion Buthus martensi Karsch, in rat formalin test. J. Ethnopharmacol. 117 (2008) 332-338
25. Mamelak A.N., Rosenfeld S., Bucholz R., Raubitschek A., Nabors L.B., Fiveash J.B., Shen S., Khazaeli M.B., Colcher D., Liu A., Osman M., Guthrie B., Schade-Bijur S., Hablitz D.M., Alvarez V.L., and Gonda M.A. Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma. J. Clin. Oncol. 24 (2006) 3644-3650
26. Li, Comp. Mater. Med., 1596.
27. Zeng X.C., Li W.X., Zhu S.Y., Peng F., Zhu Z.H., Wu K.L., and Yiang F.H. Cloning and characterization of a cDNA sequence encoding the precursor of a chlorotoxin-like peptide from the Chinese scorpion Buthus martensii Karsch. Toxicon 38 (2000) 1009-1014
28. Deshane J., Garner C.C., and Sontheimer H. Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. J. Biol. Chem. 278 (2003) 4135-4144
29. Wang W.X., and Ji Y.H. Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro. J. Neurooncol. 73 (2005) 1-7
30. Fu Y.J., Yin L.T., Liang A.H., Zhang C.F., Wang W., Chai B.F., Yang J.Y., and Fan X.J. Therapeutic potential of chlorotoxin-like neurotoxin from the Chinese scorpion for human gliomas. Neurosci. Lett. 412 (2007) 62-67
31. McConahey P.J., and Dixon F.J. Radioiodination of proteins by the use of the chloramine-T method. Methods Enzymol. 70 (1980) 210-213
32. Yoshida J., Mizuno M., Fujii M., Kajita Y., Nakahara N., Hatano M., Saito R., Nobayashi M., and Wakabayashi T. Human gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposomes. Human Gene. Ther. 15 (2004) 77-86
33. Olsen M.L., Schade S., Lyons S.A., Amaral M.D., and Sontheimer H. Expression of voltage-gated chloride channels in human glioma cells. J. Neurosci. 23 (2003) 5572-5582
34. Yamamoto M., Ueno Y., Hayashi S., and Fukushima T. The role of proteolysis in tumor invasiveness in glioblastoma and metastatic brain tumors. Anticancer Res. 22 (2002) 4265-4268
35. Hadziahmetovic M., Lo S.S., Clarke J.W., Farace E., and Cavaliere R. Palliative treatment of poor prognosis patients with malignant gliomas. Expert Rev. Anticancer Ther. 8 (2008) 125-132
36. Liotta L.A., Stetler-Stevenson W.G., and Steeg P.S. Cancer invasion and metastasis: positive and negative regulatory elements. Cancer Invest. 9 (1991) 543-551
37. Deryugina E.I., Bourdon M.A., Luo G.X., Reisfeld R.A., and Strongin A. Matrix metalloproteinase-2 activation modulates glioma cell migration. J. Cell Sci. 110 Pt 19 (1997) 2473-2482
38. McFerrin M.B., and Sontheimer H. A role for ion channels in glioma cell invasion. Neuron Glia Biol. 2 (2006) 39-49
39. Ullrich N., Bordey A., Gillespie G.Y., and Sontheimer H. Expression of voltage-activated chloride currents in acute slices of human gliomas. Neuroscience 83 (1998) 1161-1173
40. Ullrich N., Gillespie G.Y., and Sontheimer H. Human astrocytoma cells express a unique chloride current. Neuroreport 7 (1996) 1020-1024
41. Rui Y., Fang P., Hui L., Zhijian C., and Wenxin L. Functional analysis of a gene encoding a chlorotoxin-like peptide derived from scorpion toxin. Chinese J. Biochem. Mol. Biol. 21 (2005) 19-23
42. Fu Y.J., Yin L.T., Wang W., Chai B.F., and Liang A.H. Synthesis, expression and purification of a type of chlorotoxin-like peptide from the scorpion, Buthus martensii Karsch, and its acute toxicity analysis. Biotechnol. Lett. 27 (2005) 1597-1603
43. Barth R.F., Yang W., Wu G., Swindall M., Byun Y., Narayanasamy S., Tjarks W., Tordoff K., Moeschberger M.L., Eriksson S., Binns P.J., and Riley K.J. Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors. Proc. Natl. Acad. Sci. USA 105 (2008) 17493-17497
44. Levkoff L.H., Marshall II G.P., Ross H.H., Caldeira M., Reynolds B.A., Cakiroglu M., Mariani C.L., Streit W.J., and Laywell E.D. Bromodeoxyuridine inhibits cancer cell proliferation in vitro and in vivo. Neoplasia 10 (2008) 804-816
45. Ricci-Vitiani L., Pallini R., Larocca L.M., Lombardi D.G., Signore M., Pierconti F., Petrucci G., Montano N., Maira G., and De Maria R. Mesenchymal differentiation of glioblastoma stem cells. Cell Death Differ. 15 (2008) 1491-1498
46. Fiveash J.B., Gillespie G.Y., Oliver P.G., Zhou T., Belenky M.L., and Buchsbaum D.J. Enhancement of glioma radiotherapy and chemotherapy response with targeted antibody therapy against death receptor 5. Int. J. Radiat. Oncol. Biol. Phys. 71 (2008) 507-516
47. Wang J., Kim Y.S., and Liu S. 99mTc-labeling of HYNIC-conjugated cyclic RGDfK dimer and tetramer using EDDA as coligand. Bioconjug. Chem. 19 (2008) 634-642
48. Page G.G., Fennelly A.M., Littleton-Kearney M.T., and Ben-Eliyahu S. Male-female differences in the impact of beta-adrenoceptor stimulation on resistance to experimental metastasis: exploring the effects of age and gonadal hormone involvement. J. Neuroimmunol. 193 (2008) 113-119
49. Wang Si-Ying Y.L.-R., Bao-Tian Z., and Ji C. Effect of diethylstilbestrol (DES) on immune function of mice-bearing tumor and its anti-metastatic effect. Chinese Pharmacol. Bull. 12 (1996) 450-459