Early stage human colorectal cancer: Prognostic value of nm23-H1 protein overexpression

Cancer Letters

Volumn 111, Issue 1-2, 1997, Pages 1-5

  Indinnimeo, Marileda ^a   Giarnieri, Enrico ^a   Stazi, Alessandro ^a   Cicchini, Claudia ^a   Brozzetti, Stefania ^a   Valli, Clara ^a   Carreca, Ignazio ^b   Vecchione, Aldo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Colorectal cancer; nm23 gene; Prognostic factors; Recurrence

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE; PROTEIN;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; COLORECTAL CANCER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROGNOSIS; SIGNAL TRANSDUCTION;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; MONOMERIC GTP-BINDING PROTEINS; NEOPLASM PROTEINS; NEOPLASM STAGING; NUCLEOSIDE-DIPHOSPHATE KINASE; PROGNOSIS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0342711220     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(96)04472-2     Document Type: Article

References (16)

1. Steeg, P.S., Bevilacqua, G., Kopper, L., Thorgeirsson, U.P., Talmadge, J.B., Liotta, L.A. and Sobel, M.E. (1988) Evidence for a novel gene associated with low tumour metastatic potential, J. Natl. Cancer Inst., 80, 200-204.
2. Rosengard, A., Krutzsch, H., Shearn, A., Biggs, J., Barker, E. and Margulies, I. (1989) Reduced nm23/AWD protein in human metastasis and aberrant Drosophila development, Nature, 342, 177-180.
3. Stahl, J., Leone, A., Rosengard, A., Porter, L., King, C. and Steeg, P. (1991) Identification of a second human nm23 gene, nm23-H2, Cancer Res., 51, 445-449.
4. Lacombe, ML., Sastre-Garau, X., Lascu, I., Wallet, V., Thiery, J.P. and Veron, M. (1991) Overexpression of nucleoside diphosphate kinase nm23 in human solid tumours, Eur. J. Cancer, 27, 132-137.
5. Bevilacqua, G., Sobel, M.E., Lance, A., Liotta, L.A. and Steeg, P.S. (1989) Association of low nm23 RNA levels in human primary breast carcinoma with lymphnode involvement and other histopathological indicators of high metastatic potential, Cancer Res., 49, 185-190.
6. Hennessey, C. and May, B. (1991) Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis, J. Natl. Cancer Inst., 83, 281-285.
7. Barnes, R., Shala, M. and Barker, E. (1991) Low nm23 protein expression in infiltrating ductal breast carcinoma correlates with reduced patient survival, Am. J. Pathol., 139, 245-250.
8. Wang, L. and Patel, U. (1993) Mutation in the nm23 gene is associated with metastasis in colorectal cancer, Cancer Res., 53, 717-720.
9. Chen, H.C., Wang, L. and Banerjee, S. (1994) Isolation and characterization of the promoter region of human nm23-H1, a metastatic suppressor gene, Oncogene, 9, 2905-2912.
10. Campo, E. and Miquel, R. (1994) Prognostic significance of the loss of heterozigosity of nm23-H1 and p53 genes in human colorectal carcinomas, Cancer, 73, 2913-2921.
11. Cohn, K.H., Wang, F., Solomon, W.B. and Steeg, P.S. (1991) Association of nm23 allelic deletions with distant metastases in colorectal carcinoma, Lancet, 338, 722-723.
12. Haut, M., Steeg, P., Willson, J.K.W. and Markowitz, S. (1991) Induction of nm23 gene expression in human colonic neoplasm and equal expression in colon tumors of high and low metastatic potential, J. Natl. Cancer Inst., 83, 712-716.
13. Royds, J.A., Cross, S.S., Silcocks, P.B., Scholefied, J.H., Rees, R.C. and Stephenson, T.J. (1994) Nm23 antimetastatic gene product expression in colorectal carcinoma, J. Pathol., 72, 261-266.
14. Yamaguchi, A., Urano, T., Fushida, S., Furukawa, K., Nishimura, G., Yonemura, Y., Miyazaki, I., Nakagavara, G. and Shiku, H. (1993) Inverse association of nm23-H1 expression by colorectal cancer with liver metastasis, Cancer, 88, 1020-1024.
15. Heilat, N., Kein, D.R., Melhem, R.F., Zhu, X.X., Eckerskorn, C., Brodeur, G.R., Reynolds, C.P., Seeger, R.C., Lottspeich, F., Strahler, J.R. and Hanash, S.M. (1991) High levels of p19/ nm23 protein in neuroblastoma are associated with advanced stage disease and with N-Myc gene amplification, J. Clin. Invest., 88, 341-345.
16. Keim, D., Heilat, N., Melhem, R., Zhu, X.X., Lascu, I., Veron, M. and Strahler, J. (1992) Proliferation-related expression of p19/nm23 nucleoside diphosphate kinase, J. Clin. Invest., 89, 919-924.