Enzymatic synthesis of amoxicillin: Avoiding limitations of the mechanistic approach for reaction kinetics

Biotechnology and Bioengineering

Volumn 80, Issue 6, 2002, Pages 622-631

  Gonçalves, Luciana R B ^a   Sousa Jr , Ruy ^b   Fernandez Lafuente, Roberto ^c   Guisan, Jose M ^c   Giordano, Raquel L C ^b   Giordano, Roberto C ^b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^c INSTITUTO DE CATÁLISIS Y PETROLEOQUÍMICA   (Spain)

Author keywords

lactamic antibiotic; Artificial neural network; Hybrid model; Immobilized enzyme; Penicillin G acylase

Indexed keywords

ANTIBIOTICS; ENZYME KINETICS; NEURAL NETWORKS; SUBSTRATES;

BATCH REACTORS;

BIOTECHNOLOGY;

6 AMINOPENICILLANIC ACID; AGAROSE; AMOXICILLIN; GLYOXYLIC ACID DERIVATIVE; OXFENICINE; PENICILLIN G; DRUG DERIVATIVE; GLYCINE; IMMOBILIZED ENZYME; P HYDROXYPHENYLGLYCINE METHYL ESTER; P-HYDROXYPHENYLGLYCINE METHYL ESTER; PENICILLANIC ACID; PENICILLIN AMIDASE; SEPHAROSE;

ACCURACY; ARTICLE; ARTIFICIAL NEURAL NETWORK; BATCH REACTOR; CATALYSIS; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME KINETICS; FED BATCH REACTOR; MATHEMATICAL MODEL; REACTION TIME; BIOREACTOR; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; EVALUATION; GEL; KINETICS; QUALITY CONTROL; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SYNTHESIS;

AMOXICILLIN; BIOREACTORS; COMPUTER SIMULATION; ENZYMES, IMMOBILIZED; GELS; GLYCINE; KINETICS; MODELS, CHEMICAL; NEURAL NETWORKS (COMPUTER); PENICILLANIC ACID; PENICILLIN AMIDASE; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEPHAROSE;

EID: 0037146812     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10417     Document Type: Article

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