The ionic environment determines ribozyme cleavage rate by modulation of nucleobase pKa

RNA

Volumn 14, Issue 9, 2008, Pages 1942-1949

  Smith, M Duane ^a   Mehdizadeh, Reza ^a   Olive, Joan E ^a   Collins, Richard A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

General acid base catalysis; Kinetic ambiguity; Metal ions; pKa; Ribozyme mechanism

Indexed keywords

AMMONIUM CHLORIDE; CALCIUM CHLORIDE; CATION; LITHIUM CHLORIDE; MAGNESIUM CHLORIDE; MANGANESE CHLORIDE; METAL ION; NUCLEIC ACID BASE; RIBOZYME; SODIUM CHLORIDE;

ACID BASE BALANCE; ARTICLE; CATALYSIS; CHEMICAL REACTION; NEUROSPORA; NONHUMAN; PH; PH MEASUREMENT; PRIORITY JOURNAL; PROTON TRANSPORT; RNA CLEAVAGE; RNA SYNTHESIS;

CATALYSIS; CATIONS; ENDORIBONUCLEASES; HYDROGEN-ION CONCENTRATION; NUCLEOTIDES; RNA; RNA, CATALYTIC;

NEUROSPORA;

EID: 50649098884     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1102308     Document Type: Article

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