메뉴 건너뛰기




Volumn 9, Issue 14, 2009, Pages 1633-1638

Obtention and engineering of Non-Human Primate (NHP) antibodies for therapeutics

Author keywords

Antibody; Humanization; Immune library; Non human primate

Indexed keywords

ANTIGEN; COMPLEMENTARY DNA; FREUND ADJUVANT; IMMUNOGLOBULIN G; OLIGONUCLEOTIDE; RECOMBINANT ANTIBODY;

EID: 77949904546     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955709791012283     Document Type: Review
Times cited : (23)

References (24)
  • 2
    • 2942597518 scopus 로고    scopus 로고
    • A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library
    • Chassagne, S.; Laffly, E.; Drouet, E.; Herodin, F.; Lefranc, M. P.; Thullier, P. A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library. Mol. Immunol., 2004, 41, 539-46.
    • (2004) Mol. Immunol , vol.41 , pp. 539-546
    • Chassagne, S.1    Laffly, E.2    Drouet, E.3    Herodin, F.4    Lefranc, M.P.5    Thullier, P.6
  • 3
    • 34547646543 scopus 로고    scopus 로고
    • High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation
    • Pelat, T.; Hust, M.; Laffly, E.; Condemine, F.; Bottex, C.; Vidal, D.; Lefranc, M. P.; Dubel, S.; Thullier, P. High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation. Antimicrob. Agents Chemother., 2007, 51, 2758-64.
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 2758-2764
    • Pelat, T.1    Hust, M.2    Laffly, E.3    Condemine, F.4    Bottex, C.5    Vidal, D.6    Lefranc, M.P.7    Dubel, S.8    Thullier, P.9
  • 4
    • 67849092221 scopus 로고    scopus 로고
    • Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity
    • Pelat, T.; Hust, M.; Hale, M.; Lefranc, M. P.; Dubel, S.; Thullier, P. Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity. BMC Biotechnol., 2009, 9, 60.
    • (2009) BMC Biotechnol , vol.9 , pp. 60
    • Pelat, T.1    Hust, M.2    Hale, M.3    Lefranc, M.P.4    Dubel, S.5    Thullier, P.6
  • 5
    • 23044503900 scopus 로고    scopus 로고
    • Selection of a macaque Fab with framework regions like those in humans, high affinity, and ability to neutralize the protective antigen (PA) of Bacillus anthracis by binding to the segment of PA between residues 686 and 694
    • Laffly, E.; Danjou, L.; Condemine, F.; Vidal, D.; Drouet, E.; Lefranc, M. P.; Bottex, C.; Thullier, P. Selection of a macaque Fab with framework regions like those in humans, high affinity, and ability to neutralize the protective antigen (PA) of Bacillus anthracis by binding to the segment of PA between residues 686 and 694. Antimicrob. Agents Chemother., 2005, 49, 3414-20.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 3414-3420
    • Laffly, E.1    Danjou, L.2    Condemine, F.3    Vidal, D.4    Drouet, E.5    Lefranc, M.P.6    Bottex, C.7    Thullier, P.8
  • 6
    • 68949150896 scopus 로고    scopus 로고
    • Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus
    • Schütte, M.; Pelat, T.; Wezler, X.; Rosenstock, P.; Hinz, D.; Kirsch, M.; Schirrmann, T.; Thullier, P.; Hust, M.; Dübel, S. Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus. PLoS ONE, 2009, 4(8), e6625.
    • (2009) PLoS ONE , vol.4 , Issue.8
    • Schütte, M.1    Pelat, T.2    Wezler, X.3    Rosenstock, P.4    Hinz, D.5    Kirsch, M.6    Schirrmann, T.7    Thullier, P.8    Hust, M.9    Dübel, S.10
  • 7
    • 56949105189 scopus 로고    scopus 로고
    • Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering
    • Pelat, T.; Bedouelle, H.; Rees, A. R.; Crennell, S. J.; Lefranc, M. P.; Thullier, P. Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering. J. Mol. Biol., 2008, 384, 1400-7.
    • (2008) J. Mol. Biol , vol.384 , pp. 1400-1407
    • Pelat, T.1    Bedouelle, H.2    Rees, A.R.3    Crennell, S.J.4    Lefranc, M.P.5    Thullier, P.6
  • 8
    • 77649270848 scopus 로고    scopus 로고
    • Non-human primate immune libraries combined with germline humanization : An (almost) new, and powerful approach for the isolation of therapeutic antibodies
    • Pelat, T.; Thullier, P. Non-human primate immune libraries combined with germline humanization : an (almost) new, and powerful approach for the isolation of therapeutic antibodies. MAbs, 2009, 1, 377-381
    • (2009) MAbs , vol.1 , pp. 377-381
    • Pelat, T.1    Thullier, P.2
  • 9
    • 85036749290 scopus 로고    scopus 로고
    • Newman, R. A.; N. Hanna, N.; Raab, R. W. European patent 1, 266,965 B1, 24 June 1992.
    • Newman, R. A.; N. Hanna, N.; Raab, R. W. European patent 1, 266,965 B1, 24 June 1992.
  • 11
    • 0003400039 scopus 로고    scopus 로고
    • Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY
    • Barbas, C. F. Phage display : a laboratory manual; Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, 2001.
    • (2001) Phage display : A laboratory manual
    • Barbas, C.F.1
  • 14
    • 0026673067 scopus 로고
    • By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro
    • Hoogenboom, H. R.; Winter, G. By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro. J. Mol. Biol., 1992, 227, 381-8.
    • (1992) J. Mol. Biol , vol.227 , pp. 381-388
    • Hoogenboom, H.R.1    Winter, G.2
  • 15
    • 0031964765 scopus 로고    scopus 로고
    • Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: Recovery from a long-termnonprogressor SIV-infected macaque
    • Glamann, J.; Burton, D. R.; Parren, P. W.; Ditzel, H. J.; Kent, K. A.; Arnold, C.; Montefiori, D.; Hirsch, V. M. Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-termnonprogressor SIV-infected macaque. J. Virol., 1998, 72, 585-92.
    • (1998) J. Virol , vol.72 , pp. 585-592
    • Glamann, J.1    Burton, D.R.2    Parren, P.W.3    Ditzel, H.J.4    Kent, K.A.5    Arnold, C.6    Montefiori, D.7    Hirsch, V.M.8
  • 16
    • 85036757373 scopus 로고    scopus 로고
    • Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity
    • Manuscript in Progress
    • Pelat, T.; Hust, M.; Hale, M.; Lefranc, M. P.; Dübel, S.; Thullier, P. Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity. Manuscript in Progress, 2009.
    • (2009)
    • Pelat, T.1    Hust, M.2    Hale, M.3    Lefranc, M.P.4    Dübel, S.5    Thullier, P.6
  • 17
    • 85017685667 scopus 로고    scopus 로고
    • Selection of recombinant antibodies from antibody gene libraries
    • Hust, M.; Dubel, S.; Schirrmann, T. Selection of recombinant antibodies from antibody gene libraries. Methods Mol. Biol., 2007, 408, 243-55.
    • (2007) Methods Mol. Biol , vol.408 , pp. 243-255
    • Hust, M.1    Dubel, S.2    Schirrmann, T.3
  • 18
    • 52449088919 scopus 로고    scopus 로고
    • Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV)
    • Kirsch, M. I.; Hulseweh, B.; Nacke, C.; Rulker, T.; Schirrmann, T.; Marschall, H. J.; Hust, M.; Dubel, S. Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV). BMC Biotechnol., 2008, 8, 66.
    • (2008) BMC Biotechnol , vol.8 , pp. 66
    • Kirsch, M.I.1    Hulseweh, B.2    Nacke, C.3    Rulker, T.4    Schirrmann, T.5    Marschall, H.J.6    Hust, M.7    Dubel, S.8
  • 19
    • 0035169340 scopus 로고    scopus 로고
    • A helper phage to improve single-chain antibody presentation in phage display
    • Rondot, S.; Koch, J.; Breitling, F.; Dubel, S. A helper phage to improve single-chain antibody presentation in phage display. Nat Biotechnol., 2001, 19, 75-8.
    • (2001) Nat Biotechnol , vol.19 , pp. 75-78
    • Rondot, S.1    Koch, J.2    Breitling, F.3    Dubel, S.4
  • 21
    • 43049101038 scopus 로고    scopus 로고
    • Improvement of an antibody neutralizing the anthrax toxin by simultaneous mutagenesis of its six hypervariable loops
    • Laffly, E.; Pelat, T.; Cedrone, F.; Blesa, S.; Bedouelle, H.; Thullier, P. Improvement of an antibody neutralizing the anthrax toxin by simultaneous mutagenesis of its six hypervariable loops. J. Mol. Biol., 2008, 378, 1094-103.
    • (2008) J. Mol. Biol , vol.378 , pp. 1094-1103
    • Laffly, E.1    Pelat, T.2    Cedrone, F.3    Blesa, S.4    Bedouelle, H.5    Thullier, P.6
  • 23
    • 0026559783 scopus 로고
    • Antibody framework residues affecting the conformation of the hypervariable loops
    • Foote, J.; Winter, G. Antibody framework residues affecting the conformation of the hypervariable loops. J. Mol. Biol., 1992, 224, 487-99.
    • (1992) J. Mol. Biol , vol.224 , pp. 487-499
    • Foote, J.1    Winter, G.2
  • 24
    • 0037100379 scopus 로고    scopus 로고
    • Superhumanized antibodies: Reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28
    • Tan, P.; Mitchell, D. A.; Buss, T. N.; Holmes, M. A.; Anasetti, C.; Foote, J. "Superhumanized" antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28. J. Immunol., 2002, 169, 1119-25.
    • (2002) J. Immunol , vol.169 , pp. 1119-1125
    • Tan, P.1    Mitchell, D.A.2    Buss, T.N.3    Holmes, M.A.4    Anasetti, C.5    Foote, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.