Effects of levobupivacaine and bupivacaine on intracellular calcium signaling in cultured rat dorsal root ganglion neurons

Journal of Receptors and Signal Transduction

Volumn 30, Issue 2, 2010, Pages 115-120

  Ozcan, Mete ^a   Ayar, Ahmet ^b   Alcin, Ergul ^a   Ozcan, Sibel ^a   Kutlu, Selim ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Bupivacaine; Calcium imaging; Dorsal root ganglia; Levobupivacaine; Local anesthetic; Pain

Indexed keywords

BUPIVACAINE; CALCIUM ION; LEVOBUPIVACAINE; POTASSIUM CHLORIDE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTINOCICEPTION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FLUORESCENCE; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; RAT; SPINAL GANGLION;

ACTION POTENTIALS; ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; CYTOPLASM; FURA-2; GANGLIA, SPINAL; NEURONS; RATS; RATS, WISTAR;

RATTUS;

EID: 77949894323     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.3109/10799891003630614     Document Type: Article

References (27)

1. Breivik H, Borchgrevink PC, Allen SM, et al. Assessment of pain. Br J Anaesth 2008;101:17-24.
2. Leone S, Di Cianni S, Casati A, Fanelli G. Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine. Acta Biomed 2008;79:92-105.
3. Valenzuela C, Delpón E, Tamkun MM, Tamargo J, Snyders DJ. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Biophys J 1995;69:418-427
4. Nau C, Wang SY, Strichartz GR, Wang GK. Block of human heart hH1 sodium channels by the enantiomers of bupivacaine. Anesthesiology 2000;93:1022-1033
5. Butterworth JF IV, Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology 1990;72:711-734
6. Roy ML, Narahashi T. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J Neurosci 1992;12:2104-2111
7. Sugiyama K, Muteki T. Local anesthetics depress the calcium current of rat sensory neurons in culture. Anesthesiology 1994;80:1369-1378
8. Komai H, McDowell TS. Local anesthetic inhibition of voltageactivated potassium currents in rat dorsal root ganglion neurons. Anesthesiology 2001;94:1089-1095
9. Scholz A. Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels. Br J Anaesth 2002;89:52-61.
10. Vanegas H, Schaible H. Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia. Pain 2000;85:9-18.
11. Noguchi K, Obata K, Dai Y. Changes in DRG neurons and spinal excitability in neuropathy. Novartis Found Symp 2004;261:103- 10; discussion 110.
12. Zhang X, Bao L. The development and modulation of nociceptive circuitry. Curr Opin Neurobiol 2006;16:460-466
13. Zimmermann M. [History of pain treatment from 1500 to 1900]. Schmerz 2007;21:297-306.
14. Newsome S, Frawley BK, Argoff CE. Intrathecal analgesia for refractory cancer pain. Curr Pain Headache Rep 2008;12:249-256
15. Scholz A, Kuboyama N, Hempelmann G, Vogel W. Complex blockade of TTX-resistant Na+ currents by lidocaine and bupivacaine reduce firing frequency in DRG neurons. J Neurophysiol 1998;79:1746-1754
16. Scholz A, Vogel W. Tetrodotoxin-resistant action potentials in dorsal root ganglion neurons are blocked by local anesthetics. Pain 2000;89:47-52.
17. Kawano T, Oshita S, Takahashi A, et al. Molecular mechanisms of the inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on sarcolemmal adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Anesthesiology 2004;101:390-398
18. Komai H, McDowell TS. Effects of local anesthetics on opioid inhibition of calcium current in rat dorsal root ganglion neurons. Neurosci Lett 2007;418:298-303.
19. Beekwilder JP, Winkelman DL, Van Kempen GT, Van Den Berg RJ, Ypey DL. The block of total and N-type calcium conductance in mouse sensory neurons by the local anesthetic n-butyl-p-aminobenzoate. Anesth Analg 2005;100:1674-1679
20. Liu BG, Zhuang XL, Li ST, Xu GH, Brull SJ, Zhang JM. Effects of bupivacaine and ropivacaine on high-voltage-activated calcium currents of the dorsal horn neurons in newborn rats. Anesthesiology 2001;95:139-143
21. Burlacu CL, Buggy DJ. Update on local anesthetics: focus on levobupivacaine. Ther Clin Risk Manag 2008;4:381-392
22. Kong VK, Irwin MG. Adjuvant analgesics in neuropathic pain. Eur J Anaesthesiol 2009;26:96-100.
23. Kanai A, Sarantopoulos C, McCallum JB, Hogan Q. Painful neuropathy alters the effect of gabapentin on sensory neuron excitability in rats. Acta Anaesthesiol Scand 2004;48:507-512
24. Ozcan M, Ayar A, Canpolat S, Kutlu S. Antinociceptive efficacy of levetiracetam in a mice model for painful diabetic neuropathy. Acta Anaesthesiol Scand 2008;52:926-930
25. Sutton KG, Martin DJ, Pinnock RD, Lee K, Scott RH. Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones. Br J Pharmacol 2002;135:257-265
26. Ozcan M, Alcin E, Kutlu S, Ayar A. Levetiracetam inhibits calcium signalling in cultured dorsal root ganglia neurons from neonatal rats. J Physiol Proc Physiol Soc 2008;11:PC107.
27. Bennett MI, Simpson KH. Gabapentin in the treatment of neuropathic pain. Palliat Med 2004;18:5-11.