Painful neuropathy alters the effect of gabapentin on sensory neuron excitability in rats

Acta Anaesthesiologica Scandinavica

Volumn 48, Issue 4, 2004, Pages 507-512

  Kanai, Akifumi ^a,c   Sarantopoulos, C ^b   McCallum, J B ^b   Hogan, Q ^b  

^a KITASATO UNIVERSITY   (Japan)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Gabapentin; Nerve injury; Neuronal excitability; Neuropathic pain

Indexed keywords

ANTICONVULSIVE AGENT; GABAPENTIN; SODIUM CHANNEL;

AFTERHYPERPOLARIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; DEPOLARIZATION; DRUG MECHANISM; MYELINATED NERVE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NERVE COMPRESSION; NERVE CONDUCTION; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; REFRACTORY PERIOD; SCIATIC NERVE; SCIATIC NEUROPATHY; SENSORY NERVE CELL; SPINAL GANGLION;

ACETIC ACIDS; ACTION POTENTIALS; AMINES; ANALGESICS; ANALYSIS OF VARIANCE; ANIMALS; CALCIUM CHANNELS; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGY; GAMMA-AMINOBUTYRIC ACID; GANGLIA, SPINAL; MALE; MICROELECTRODES; NERVE FIBERS, MYELINATED; NEURONS, AFFERENT; PAIN; RATS; SCIATIC NERVE;

EID: 1942502304     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2004.00356.x     Document Type: Article

References (31)

1. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 1998; 280: 1837-42.
2. Backonja M, Beydoun A, Edwards KR et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 1998; 280: 1831-6.
3. Gee NS, Brown JP, Dissanayake VU, Offord J, Thurlow R, Woodruff GN. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. J Biol Chem 1996; 271: 5768-76.
4. Malmberg AB, Yaksh TL. Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain 1995; 60: 83-90.
5. Wong CH, Dey P, Yarmush J, Wu WH, Zbuzek VK. Nifedipine-induced analgesia after epidural injection in rats. Anesth Analg 1994; 79: 303-6.
6. Diaz A, Dickenson AH. Blockade of spinal N- and P-type, but not 1-type, calcium channels inhibits the excitability of rat dorsal horn neurones produced by subcutaneous formalin inflammation. Pain 1997; 69: 93-100.
7. Shimoyama M, Shimoyama N, Hori Y. Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain 2000; 85: 405-14.
8. Patel M, Gonzales M, Bramwell S, Pinnock R, Lee K. Gabapentin inhibits excitatory transmission in the hyperalgesic spinal cord. Br J Pharmacol 2000; 130: 1731-4.
9. Stefani A, Spadoni F, Bernardi G. Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology 1998; 37: 83-91.
10. Rock DM, Kelly KM, Macdonald RL. Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons. Epilepsy Res 1993; 16: 89-98.
11. Devor M, Seltzer Z. Pathophysiology of damaged nerves in relation to chronic pain. In: Wall PD, Melzack R, eds. Textbook of Pain, 4th edn. Edingburgh: Churchill Livingstone, 1999.
12. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988; 33: 87-107.
13. Villiere V, McLachlan EM. Electrophysiological properties of neurons in intact rat dorsal root ganglia classified by conduction velocity and action potential duration. J Neurophysiol 1996; 76: 1924-41.
14. Sarantopoulos C, McCallum B, Kwok W-M, Hogan Q. Gabapentin decreases membrane calcium currents in injured as well as in control mammalian primary afferent neurons. Reg Anesth Pain Med 2002; 27: 47-57.
15. Wall PD, Devor M. Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats. Pain 1983; 17: 321-39.
16. Study RE, Kral MG. Spontaneous action potential activity in isolated dorsal root ganglion neurons from rats with a painful neuropathy. Pain 1996; 65: 235-42.
17. Babbedge RC, Soper AJ, Gentry CT, Hood VC, Campbell EA, Urban L. In vitro characterization of a peripheral afferent pathway of the rat after chronic sciatic nerve section. J Neurophysiol 1996; 76: 3169-77.
18. Na HS, Leem JW, Chung JM. Abnormalities of mechanoreceptors in a rat model of neuropathic pain: possible involvement in mediating mechanical allodynia. J Neurophysiol 1993; 70: 522-8.
19. Harper AA, Lawson SN. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurons. J Neurophysiol 1985; 359: 31-46.
20. Kajander KC, Bennet GJ. Onset of a painful peripheral neuropathy in rat. a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. J Neurophysiol 1992; 68: 734-44.
21. Scroggs RS, Fox AP. Calcium current variation between acutely isolated adult rat dorsal ganglion neurons of different size. J Physiol 1992; 445: 639-58.
22. + currents in neurons, types, physiological roles and modulation. Trends Neurosciences 1996; 19: 150-4.
23. Hogan QH, McCallum JP, Sarantopoulos C, et al. Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons. Pain 2000; 86: 43-53.
24. Brock JA, McLachlan EM, Belmonte C. Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea. J Physiol 1998; 512: 221-7.
25. Rizzo MA, Kocsis JD, Waxman SG. Selective loss of slow and enhancement of fast Na+ currents in cutaneous afferent dorsal root ganglion neurons following axotomy. Neurobiol Dis 1995; 2: 87-96.
26. Cummins TR, Waxman SG. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J Neurosci 1997; 17: 3503-14.
27. Kral MG, Xiong Z, Study RE. Alteration of Na+ currents in dorsal root ganglion neurons from rats with a painful neuropathy. Pain 1999; 81: 15-24.
28. Brau ME, Dreimann M, Olschewski A, Vogel W, Hempelmann G. effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na (+) currents in rat sensory neurons. Anesthesiology 2001; 94: 137-44.
29. Pan HL, Eisenach JC, Chen SR. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacolo Exp Ther 1999; 288: 1026-30.
30. Wamill AW, McLean MJ. Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture. Epilepsy Res 1994; 17: 1-11.
31. Devor M, Wall PD, Catalan N. systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 1992; 48: 261-8.