The block of total and N-type calcium conductance in mouse sensory neurons by the local anesthetic n-butyl-p-aminobenzoate

Anesthesia and Analgesia

Volumn 100, Issue 6, 2005, Pages 1674-1679

  Beekwilder, Jeroen P ^a   Winkelman, Daniel L B ^a   Van Kempen, Gertrudis Th H ^a   Van Den Berg, Rutgeris J ^a   Ypey, Dirk L ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYLCAINE; CALCIUM CHANNEL N TYPE; LOCAL ANESTHETIC AGENT;

ANALGESIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CONCENTRATION RESPONSE; LOCAL ANESTHESIA; MATHEMATICAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION; VOLTAGE CLAMP; WHOLE CELL;

ACTION POTENTIALS; ALGORITHMS; ANESTHETICS, LOCAL; ANIMALS; ANIMALS, NEWBORN; BARIUM; BENZOCAINE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; GANGLIA, SPINAL; MEMBRANE POTENTIALS; MICE; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES;

EID: 19044363329     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000151162.07211.DD     Document Type: Article

References (25)

1. Shulman M. Treatment of cancer pain with epidural butylaminobenzoate suspension. Reg Anesth 1987;12:1-4.
2. Shulman M, Lubenow TR, Nath HA, et al. Nerve blocks with 5% butamben suspension for the treatment of chronic pain syndromes. Reg Anesth Pain Med 1998;23:395-401.
3. Korsten HH, Ackerman EW, Grouls RJ, et al. Long-lasting epidural sensory blockade by n-butyl-p-aminobenzoate in the terminally ill intractable cancer pain patient. Anesthesiology 1991;75:950-60.
4. Van den Berg RJ, Van Soest PF, Wang Z, et al. The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. Anesthesiology 1995;82:1463-73.
5. Van den Berg RJ, Wang Z, Grouls RJ, Korsten HH. The local anesthetic, n-butyl-p-aminobenzoate, reduces rat sensory neuron excitability by differential actions on fast and slow Na+ current components. Eur J Pharmacol 1996;316:87-95.
6. Butterworth JF, Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology 1990;72:711-34.
7. Beekwilder JP, O'Leary ME, van den Broek LP, et al. Kv1.1 channels of dorsal root ganglion neurons are inhibited by n-butyl-p-aminobenzoate, a promising anesthetic for the treatment of chronic pain. J Pharmacol Exp Ther 2003;304:531-8.
8. Diochot S, Richard S, Valmier J. Diversity of voltage-gated calcium currents in large diameter embryonic mouse sensory neurons. Neuroscience 1995;69:627-41.
9. Mintz IM, Adams ME, Bean BP. P-type calcium channels in rat central and peripheral neurons. Neuron 1992;9:85-95.
10. 2+ currents elicited by action potential waveforms in acutely isolated adult rat dorsal root ganglion neurons. J Neurosci 1992;12:1789-801.
11. 2+ current in the action potentials of nociceptive sensory neurons. J Neurosci 2002;22:10277-90.
12. Bell TJ, Thaler C, Castiglioni AJ, et al. Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron 2004;41:127-38.
13. Scroggs RS, Fox AP. Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size. J Neurosci 1992;445:639-58.
14. Buisman HP, De Vos A, Ypey DL. A pipette holder for use in patch-clamp measurements. J Neurosci Methods 1990;31:89-91.
15. 2+ channels. Neuroreport 2001;12:2423-7.
16. Kim C, Jun K, Lee T, et al. Altered nociceptive response in mice deficient in the alpha(1B) subunit of the voltage-dependent calcium channel. Mol Cell Neurosci 2001;18:235-45.
17. 2+ channel. EMBO J 2001;20:2349-56.
18. Grouls RJ, Meert TF, Korsten HH, et al. Epidural and intrathecal n-butyl-p-aminobenzoate solution in the rat: comparison with bupivacaine. Anesthesiology 1997;86:181-7.
19. Franz DN, Perry RS. Mechanisms for differential block among single myelinated and non-myelinated axons by procaine. J Physiol 1974;236:193-210.
20. Waxman SG, Ritchie JM. Molecular dissection of the myelinated axon. Ann Neurol 1993;33:121-36.
21. Elliott P. Action of antiepileptic and anaesthetic drugs on Na- and Ca-spikes in mammalian non-myelinated axons. Eur J Pharmacol 1990;175:155-63.
22. Quasthoff S, Grosskreutz J, Schroder JM, et al. Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibres of biopsied human sural nerve. Neuroscience 1995;69:955-65.
23. 2+ transients in nociceptive human C fibres. Pain 1999;81:317-22.
24. Sugiyama K, Muteki T. Local anesthetics depress the calcium current of rat sensory neurons in culture. Anesthesiology 1994;80:1369-78.
25. Liu B-G, Zhuang X-L, Li S-T, et al. Effects of bupivacaine and ropivacaine on high-voltage-activated calcium currents of the dorsal horn neurons in newborn rats. Anesthesiology 2001;95:139-43.