Effects of local anesthetics on opioid inhibition of calcium current in rat dorsal root ganglion neurons

Neuroscience Letters

Volumn 418, Issue 3, 2007, Pages 298-303

  Komai, Hirochika ^a   McDowell, Thomas S ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Calcium channels; DRG neurons; G proteins; Local anesthetics; Opioids; Sensory neurons

Indexed keywords

BUPIVACAINE; CALCIUM; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; LOCAL ANESTHETIC AGENT; MU OPIATE RECEPTOR AGONIST; OPIATE; TETRACAINE;

ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION;

ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANESTHETICS, LOCAL; ANIMALS; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FEMALE; GANGLIA, SPINAL; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MEMBRANE POTENTIALS; NEURAL INHIBITION; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; TETRACAINE;

EID: 34247622995     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.03.041     Document Type: Article

References (14)

1. i protein function. Anesthesiology 99 (2003) 1093-1101
2. Cooper D.W., and Turner G. Patient-controlled extradural analgesia to compare bupivacaine, fentanyl and bupivacaine with fentanyl in the treatment of postoperative pain. Br. J. Anaesth. 70 (1993) 503-507
3. Elmslie K.S. Neurotransmitter modulation of neuronal calcium channels. J. Bioenerg. Biomembr. 35 (2003) 477-489
4. Hageluken A., Grunbaum L., Nurnberg B., Harhammer R., Schunack W., and Seifert R. Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. Biochem. Pharmacol. 47 (1994) 1789-1795
5. 2+ channels by G-protein βγ subunits. Nature 380 (1996) 258-262
6. q protein function. Mol. Pharmacol. 59 (2001) 294-301
7. Ikeda S. Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits. Nature 380 (1996) 255-258
8. Ikeda S.R. Double-pulse calcium channel current facilitation in adult rat sympathetic neurones. J. Physiol. 439 (1991) 181-214
9. Komai H., and McDowell T.S. Local anesthetic inhibition of voltage-activated potassium currents in rat dorsal root ganglion neurons. Anesthesiology 94 (2001) 1089-1095
10. o-type GTP-binding protein. J. Neurosci. 14 (1994) 3842-3851
11. Scholz A. Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels. Br. J. Anaesth. 89 (2002) 52-61
12. Sugiyama K., and Muteki T. Local anesthetics depress the calcium current of rat sensory neurons in culture. Anesthesiology 80 (1994) 1369-1378
13. ++ currents in anterior pituitary cells. Mol. Pharmacol. 55 (1999) 150-158
14. Zamponi G.W., and Snutch T.P. Decay of prepulse facilitation of N type calcium channels during G protein inhibition is consistent with binding of a single Gβγ subunit. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 4035-4039