Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 153, Issue 3, 2010, Pages 802-811

  Ehlers, Cindy L ^a   Gizer, Ian R ^b   Vieten, Cassandra ^c   Wilhelmsen, Kirk C ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

Dependence; Genome scan; Heritability; Marijuana

Indexed keywords

ADULT; ARTICLE; CANNABIS ADDICTION; CHROMOSOME 1; CHROMOSOME 3; CHROMOSOME 6; CHROMOSOME 7; CHROMOSOME 9; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; WITHDRAWAL SYNDROME;

ALCOHOLISM; CHROMOSOME MAPPING; COMPUTER SIMULATION; FAMILY; FEMALE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; MARIJUANA ABUSE; MIDDLE AGED; PHENOTYPE; SAN FRANCISCO; SUBSTANCE WITHDRAWAL SYNDROME;

CANNABIS; CANNABIS SATIVA;

EID: 77949834011     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31050     Document Type: Article

References (85)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. 2002. Merlin - Rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30(1):97-101.
2. Agrawal A, Lynskey MT. 2006. The genetic epidemiology of cannabis use, abuse and dependence. Addiction 101(6):801-812.
3. Agrawal A, Pergadia ML, Saccone SF, Lynskey MT, Wang JC, Martin NG, Statham D, Henders A, Campbell M, Garcia R, et al. 2008a. An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. Arch Gen Psychiatry 65(6):713-721.
4. Agrawal A, Morley KI, Hansell NK, Pergadia ML, Montgomery GW, Statham DJ, Todd RD, Madden PA, Heath AC, Whitfield J, et al. 2008b. Autosomal linkage analysis for cannabis use behaviors in Australian adults. Drug Alcohol Depend 98(3):185-190.
5. Agrawal A, Pergadia ML, Lynskey MT. 2008c. Is there evidence for symptoms of cannabis withdrawal in the national epidemiologic survey of alcohol and related conditions? Am J Addict 17(3):199-208.
6. Agrawal A, Hinrichs AL, Dunn G, Bertelsen S, Dick DM, Saccone SF, Saccone NL, Grucza RA, Wang JC, Cloninger CR, et al. 2008d. Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug Alcohol Depend 93(1-2):12-20.
7. Almasy L, Blangero J. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62(5):1198-1211.
8. Anthony JC, Warner LA, Kessler RC. 1994. Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: Basic findings from the National Comorbididty Survey. Exp Clin Psychopharmacol 2(3):244-268.
9. Anton RF. 1999. What is craving? Models and implications for treatment. Alcohol Res Health 23(3):165-173.
10. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI Jr, Reich T, Schmidt I, Schuckit MA. 1994. A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA. J Stud Alcohol 55(2):149-158.
11. Budney AJ, Hughes JR. 2006. The cannabis withdrawal syndrome. Curr Opin Psychiatry 19(3):233-238.
12. Budney AJ, Novy PL, Hughes JR. 1999. Marijuana withdrawal among adults seeking treatment for marijuana dependence. Addiction 94(9):1311-1322.
13. Budney AJ, Moore BA, Vandrey RG, Hughes JR. 2003. The time course and significance of cannabis withdrawal. J Abnorm Psychol 112(3):393-402.
14. Budney AJ, Hughes JR, Moore BA, Vandrey R. 2004. Review of the validity and significance of cannabis withdrawal syndrome. Am J Psychiatry 161(11):1967-1977.
15. Budney AJ, Vandrey RG, Hughes JR, Thostenson JD, Bursac Z. 2008. Comparison of cannabis and tobacco withdrawal: Severity and contribution to relapse. J Subst Abuse Treat 35(4):362-368.
16. Compton WM, Grant BF, Colliver JD, Glantz MD, Stinson FS. 2004. Prevalence of marijuana use disorders in the United States: 1991-1992 and 2001-2002. J Am Med Assoc 291(17):2114-2121.
17. De Bruijn C, Korzec A, Koerselman F, van den Brink W. 2004. Craving and withdrawal as core symptoms of alcohol dependence. J Nerv Ment Dis 192(7):494-502.
18. Degenhardt L, Hall W, Lynskey M. 2003. Exploring the association between cannabis use and depression. Addiction 98(11):1493-1504.
19. Dick DM, Nurnberger J Jr, Edenberg HJ, Goate A, Crowe R, Rice J, Bucholz KK, Kramer J, Schuckit MA, Smith TL, et al. 2002. Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype. Alcohol Clin Exp Res 26(10):1453-1460.
20. Dick DM, Aliev F, Wang JC, Saccone S, Hinrichs A, Bertelsen S, Budde J, Saccone N, Foroud T, Nurnberger J Jr, et al. 2008. A systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. Biol Psychiatry 63(11):1047-1053.
21. Dunn G, Hinrichs AL, Bertelsen S, Jin CH, Kauwe JS, Suarez BK, Bierut LJ. 2005. Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures. BMC Genet 6(Suppl. 1):S122.
22. Edwards G. 1986. The alcohol dependence syndrome: A concept as stimulus to enquiry. Br J Addict 81(2):171-183.
23. Ehlers CL, Wall TL, Betancourt M, Gilder DA. 2004a. The clinical course of alcoholism in 243 Mission Indians. Am J Psychiatry 161(7):1204-1210.
24. Ehlers CL, Gilder DA, Wall TL, Phillips E, Feiler H, Wilhelmsen KC. 2004b. Genomic screen for loci associated with alcohol dependence in Mission Indians. Am J Med Genet Part B 129B(1):110-115.
25. Ehlers CL, Gilder DA, Slutske WS, Lind PA, Wilhelmsen KC. 2008. Externalizing disorders in American Indians: Comorbidity and a genome wide linkage analysis. Am J Med Genet Part B 147B(6):690-698.
26. Ehlers CL, Gilder DA, Gizer IR, Wilhelmsen KC. 2009. Heritability and a genome-wide linkage analysis of a type II/B cluster construct for cannabis dependence in an American Indian community. Addict Biol 14(3):338-348.
27. Fergusson DM, Horwood LJ. 2000. Does cannabis use encourage other forms of illicit drug use? Addiction 95(4):505-520.
28. Field M, Mogg K, Bradley BP. 2004. Cognitive bias and drug craving in recreational cannabis users. Drug Alcohol Depend 74(1):105-111.
29. Fisher BA, Ghuran A, Vadamalai V, Antonios TF. 2005. Cardiovascular complications induced by cannabis smoking: A case report and review of the literature. Emerg Med J 22(9):679-680.
30. Gelernter J, Panhuysen C, Weiss R, Brady K, Hesselbrock V, Rounsaville B, Poling J, Wilcox M, Farrer L, Kranzler HR. 2005. Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine-related trait and cocaine-induced paranoia. Am J Med Genet Part B 136B(1):45-52.
31. Gelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J, Weiss R, Sonne S, Zhao H, Farrer L, et al. 2006. Genomewide linkage scan for opioid dependence and related traits. Am J Hum Genet 78(5):759-769.
32. Gizer IR, Ehlers CL, Vietan C, Seaton-Smith KL, Feiler HS, Lee JV, Segall SK, Wilhelmsen KC. 2009. Linkage scan of alcohol dependence in the UCSF family alcoholism study. Alcohol Clin Exp Res 33(6):14A.
33. Gottesman II, Gould TD. 2003. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 160(4):636-645.
34. Hall WD, Degenhardt L, Teesson M. 2004. Cannabis use and psychotic disorders: An update. Drug Alcohol Rev 23(4):433-443.
35. Hashibe M, Straif K, Tashkin DP, Morgenstern H, Greenland S, Zhang ZF. 2005. Epidemiologic review of marijuana use and cancer risk. Alcohol 35(3):265-275.
36. Hasin D, Paykin A, Meydan J, Grant B. 2000. Withdrawal and tolerance: Prognostic significance in DSM-IV alcohol dependence. J Stud Alcohol 61(3):431-438.
37. Hasin D, Hatzenbuehler ML, Keyes K, Ogburn E. 2006. Substance use disorders: Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) and International Classification of Diseases, tenth edition (ICD-10). Addiction 101(Suppl.):159-175.
38. Hasin DS, Keyes KM, Alderson D, Wang S, Aharonovich E, Grant BF. 2008. Cannabis withdrawal in the United States: Results from NESARC. J Clin Psychiatry 69(9):1354-1363.
39. Haughey HM, Marshall E, Schacht JP, Louis A, Hutchison KE. 2008. Marijuana withdrawal and craving: Influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction 103(10):1678-1686.
40. Heishman SJ, Singleton EG. 2006. Assessment of cannabis craving using the Marijuana Craving Questionnaire. Methods Mol Med 123:209-216.
41. Hill SY, Shen S, Zezza N, Hoffman EK, Perlin M, Allan W. 2004. A genome wide search for alcoholism susceptibility genes. Am J Med Genet Part B 128B(1):102-113.
42. Hopfer CJ, Lessem JM, Hartman CA, Stallings MC, Cherny SS, Corley RP, Hewitt JK, Krauter KS, Mikulich-Gilbertson SK, Rhee SH, et al. 2007. A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9. Drug Alcohol Depend 89(1):34-41.
43. Kandel DB, Chen K. 2000. Types of marijuana users by longitudinal course. J Stud Alcohol 61(3):367-378.
44. Kendler KS, Prescott CA. 1998. Cannabis use, abuse, and dependence in a population-based sample of female twins. Am J Psychiatry 155(8):1016-1022.
45. Kendler KS, Karkowski LM, Neale MC, Prescott CA. 2000. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch Gen Psychiatry 57(3):261-269.
46. Kendler KS, Jacobson KC, Prescott CA, Neale MC. 2003. Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry 160(4):687-695.
47. Koob GF. 2000. Animal models of craving for ethanol. Addiction 95(Suppl. 2):S73-S81.
48. Lynskey M, Hall W. 2000. The effects of adolescent cannabis use on educational attainment: A review. Addiction 95(11):1621-1630.
49. Lynskey MT, Heath AC, Nelson EC, Bucholz KK, Madden PA, Slutske WS, Statham DJ, Martin NG. 2002. Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. Psychol Med 32(2):195-207.
50. Lynskey MT, Heath AC, Bucholz KK, Slutske WS, Madden PA, Nelson EC, Statham DJ, Martin NG. 2003. Escalation of drug use in early-onset cannabis users vs co-twin controls. J Am Med Assoc 289(4):427-433.
51. Maes HH, Woodard CE, Murrelle L, Meyer JM, Silberg JL, Hewitt JK, Rutter M, Simonoff E, Pickles A, Carbonneau R, et al. 1999. Tobacco, alcohol and drug use in eight- to sixteen-year-old twins: The Virginia Twin Study of Adolescent Behavioral Development. J Stud Alcohol 60(3):293-305.
52. McGue M, Elkins I, Iacono WG. 2000. Genetic and environmental influences on adolescent substance use and abuse. Am J Med Genet Part B 96B(5):671-677.
53. McPeek MS, Sun L. 2000. Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 66(3):1076-1094.
54. Miles DR, van den Bree MB, Gupman AE, Newlin DB, Glantz MD, Pickens RW. 2001. A twin study on sensation seeking, risk taking behavior and marijuana use. Drug Alcohol Depend 62(1):57-68.
55. Mittleman MA, Lewis RA, Maclure M, Sherwood JB, Muller JE. 2001. Triggering myocardial infarction by marijuana. Circulation 103(23):2805-2809.
56. Nurnberger JI Jr, Foroud T, Flury L, Su J, Meyer ET, Hu K, Crowe R, Edenberg H, Goate A, Bierut L, et al. 2001. Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. Am J Psychiatry 158(5):718-724.
57. O'Connell JR, Weeks DE. 1998. PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63(1):259-266.
58. Pope HG Jr, Gruber AJ, Hudson JI, Huestis MA, Yurgelun-Todd D. 2001. Neuropsychological performance in long-term cannabis users. Arch Gen Psychiatry 58(10):909-915.
59. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, et al. 1998. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Hum Genet 81(3):207-215.
60. Rhee SH, Hewitt JK, Young SE, Corley RP, Crowley TJ, Stallings MC. 2003. Genetic and environmental influences on substance initiation, use, and problem use in adolescents. Arch Gen Psychiatry 60(12):1256-1264.
61. Robinson TE, Berridge KC. 1993. The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18(3):247-291.
62. Schuckit MA. 1995. Drug and alcohol abuse: A clinical guide to diagnosis and treatment. New York: Plenum Medical Book Co.
63. Schuckit MA. 2006. Drug and alcohol abuse. New York: Springer Science + Business Media, Inc.
64. Schuckit MA, Daeppen JB, Danko GP, Tripp ML, Smith TL, Li TK, Hesselbrock VM, Bucholz KK. 1999. Clinical implications for four drugs of the DSM-IV distinction between substance dependence with and without a physiological component. Am J Psychiatry 156(1):41-49.
65. Schuckit MA, Edenberg HJ, Kalmijn J, Flury L, Smith TL, Reich T, Bierut L, Goate A, Foroud T. 2001. A genome-wide search for genes that relate to a low level of response to alcohol. Alcohol Clin Exp Res 25(3):323-329.
66. Seaton KL, Cornell JL, Wilhelmsen KC, Vieten C. 2004. Effective strategies for recruiting families ascertained through alcoholic probands. Alcohol Clin Exp Res 28(1):78-84.
67. Southwest Foundation for Biomedical Research [SFBR]. 2009. Sequential oligogenic linkage analysis routines. San Antonio, TX: Southwest Foundation for Biomedical Research. Available at: http://solar.sfbrgenetics.org/.
68. Sharma BP. 1975. Cannabis and its users in Nepal. Br J Psychiatry 127:550-552.
69. Sinha R, O'Malley SS. 1999. Craving for alcohol: Findings from the clinic and the laboratory. Alcohol Alcohol 34(2):223-230.
70. Solowij N, Stephens RS, Roffman RA, Babor T, Kadden R, Miller M, Christiansen K, McRee B, Vendetti J. 2002. Cognitive functioning of long-term heavy cannabis users seeking treatment. J Am Med Assoc 287(9):1123-1131.
71. Stallings MC, Corley RP, Hewitt JK, Krauter KS, Lessem JM, Mikulich SK, Rhee SH, Smolen A, Young SE, Crowley TJ. 2003. A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. Drug Alcohol Depend 70(3):295-307.
72. Stallings MC, Corley RP, Dennehey B, Hewitt JK, Krauter KS, Lessem JM, Mikulich-Gilbertson SK, Rhee SH, Smolen A, Young SE, et al. 2005. A genome-wide search for quantitative trait loci that influence antisocial drug dependence in adolescence. Arch Gen Psychiatry 62(9):1042-1051.
73. Stinson FS, Grant BF, Dawson DA, Ruan WJ, Huang B, Saha T. 2005. Comorbidity between DSM-IV alcohol and specific drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Drug Alcohol Depend 80(1):105-116.
74. Stinson FS, Ruan WJ, Pickering R, Grant BF. 2006. Cannabis use disorders in the USA: Prevalence, correlates and co-morbidity. Psychol Med 36(10):1447-1460.
75. Swift W, Hall W, Teesson M. 2001. Cannabis use and dependence among Australian adults: Results from the National Survey of Mental Health and Wellbeing. Addiction 96(5):737-748.
76. Tashkin DP. 2005. Smoked marijuana as a cause of lung injury. Monaldi Arch Chest Dis 63(2):93-100.
77. Taylor DR, Poulton R, Moffitt TE, Ramankutty P, Sears MR. 2000. The respiratory effects of cannabis dependence in young adults. Addiction 95(11):1669-1677.
78. Tsuang MT, Lyons MJ, Meyer JM, Doyle T, Eisen SA, Goldberg J, True W, Lin N, Toomey R, Eaves L. 1998. Co-occurrence of abuse of different drugs in men: The role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry 55(11):967-972.
79. van den Bree MB, Johnson EO, Neale MC, Svikis DS, McGue M, Pickens RW. 1998. Genetic analysis of diagnostic systems of alcoholism in males. Biol Psychiatry 43(2):139-145.
80. Vieten C, Seaton KL, Feiler HS, Wilhelmsen KC. 2004. The University of California, San Francisco Family Alcoholism Study. I. Design, methods, and demographics. Alcohol Clin Exp Res 28(10):1509-1516.
81. Wang JC, Hinrichs AL, Stock H, Budde J, Allen R, Bertelsen S, Kwon JM, Wu W, Dick DM, Rice J, et al. 2004. Evidence of common and specific genetic effects: Association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Hum Mol Genet 13(17):1903-1911.
82. Wiesbeck GA, Schuckit MA, Kalmijn JA, Tipp JE, Bucholz KK, Smith TL. 1996. An evaluation of the history of a marijuana withdrawal syndrome in a large population. Addiction 91(10):1469-1478.
83. Wilhelmsen KC, Ehlers C. 2005. Heritability of substance dependence in a native American population. Psychiatr Genet 15(2):101-107.
84. Wilhelmsen KC, Schuckit M, Smith TL, Lee JV, Segall SK, Feiler HS, Kalmijn J. 2003. The search for genes related to a low-level response to alcohol determined by alcohol challenges. Alcohol Clin Exp Res 27(7):1041-1047.
85. Wise RA. 1988. The neurobiology of craving: Implications for the understanding and treatment of addiction. J Abnorm Psychol 97(2):118-132.