The search for genes related to a low-level response to alcohol determined by alcohol challenges

Alcoholism: Clinical and Experimental Research

Volumn 27, Issue 7, 2003, Pages 1041-1047

  Wilhelmsen, Kirk C ^a,b,d   Schuckit, Marc ^c   Smith, Tom L ^c   Lee, James V ^a   Segall, Samantha K ^a   Feiler, Heidi S ^a   Kalmijn, Jelger ^c  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d EGCRC   (United States)

Author keywords

Alcohol; Genetics; Level of Response; Linkage

Indexed keywords

ALCOHOL;

ADOLESCENT; ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; DRINKING BEHAVIOR; DRUG EFFECT; FEMALE; GENE ISOLATION; GENETIC LINKAGE; GENETICS; GENOTYPE; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PEDIGREE; PHENOTYPE; PRIORITY JOURNAL; QUESTIONNAIRE; RATING SCALE; RISK FACTOR; SCORING SYSTEM; SEGREGATION ANALYSIS;

ADOLESCENT; ADULT; ALCOHOL DRINKING; ETHANOL; FEMALE; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; PEDIGREE; PHENOTYPE;

EID: 0038713003     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000075551.02714.63     Document Type: Article

References (41)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR (2002) Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101.
2. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
3. Almasy L, Porjesz B, Blangero J, Goate A, Edenberg HJ, Chorlian DB, Kuperman S, O'Connor SJ, Rohrbaugh J, Bauer LO, Foroud T, Rice JP, Reich T, Begleiter H (2001) Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. Am J Hum Genet 68:128-135.
4. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders: DSM-IV. American Psychiatric Association, Washington, DC.
5. Begleiter H, Porjesz B (1999) What is inherited in the predisposition toward alcoholism? A proposed model. Alcohol Clin Exp Res 23:1125-1135.
6. Dick DM, Nurnberger JI Jr, Edenberg HJ, Goate A, Crowe R, Rice J, Bucholz KK, Kramer J, Schuckit MA, Smith TL, Porjesz B, Begleiter H, Hesselbrock V, Foroud T (2002) Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype. Alcohol Clin Exp Res 26:1453-1460.
7. Ehlers CL, Garcia-Andrade C, Wall TL, Cloutier D, Phillips E (1999) Electroencephalographic responses to alcohol challenge in Native American Mission Indians. Biol Psychiatry 45:776-787.
8. Erblich J, Earleywine M (1999) Children of alcoholics exhibit attenuated cognitive impairment during an ethanol challenge. Alcohol Clin Exp Res 23:476-482.
9. Foroud T, Edenberg HJ, Goate A, Rice J, Flury L, Koller DL, Bierut LJ, Conneally PM, Nurnberger JI Jr, Bucholz KK, Li T-K, Hesselbrock VM, Crowe R, Schuckit MA, Porjesz B, Begleiter H, Reich T (2000) Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24:933-945.
10. Heath AC, Madden PA, Bucholz KK, Dinwiddie SH, Slutske WS, Bierut LJ, Rohrbaugh JW, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1999) Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk. Psychol Med 29:1069-1081.
11. Hesselbrock M, Easton C, Bucholz KK, Schuckit MA, Hesselbrock V (1999) A validity study of the SSAGA - a comparison with the SCAN. Addiction 94:1361-1370.
12. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
13. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247.
14. Li T-K (2000) Pharmacogenetics of responses to alcohol and genes that influence alcohol drinking. J Stud Alcohol 61:5-12.
15. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, Bennett PH, Goldman D (1998) Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216-221.
16. McPeek MS, Sun L (2000) Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 66:1076-1094.
17. Mendelson JH, McGuire M, Mello NK (1984) A new device for administering placebo alcohol. Alcohol 1:417-419.
18. Morton NE (1955) Sequential tests for detection of linkage. Am J Hum Genet 7:277-318.
19. Nurnberger JI Jr, Foroud T, Flury L, Su J, Meyer ET, Hu K, Crowe R, Edenberg H, Goate A, Bierut L, Reich T, Schuckit MA, Reich W (2001) Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. Am J Psychiatry 158:718-724.
20. O'Connell JR, Weeks DE (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266.
21. Porjesz B, Almasy L, Edenberg HJ, Wang KM, Chorlian DB, Foroud T, Goate A, Rice JP, O'Connor SJ, Rohrbaugh J, Kuperman S, Bauer LO, Crowe RR, Schuckit MA, Hesselbrock V, Conneally PM, Tischfield JA, Li T-K, Reich T, Begleiter H (2002) Linkage disequilibrium between the beta frequency of the human EEG and a GABA(A) receptor gene locus. Proc Natl Acad Sci USA 99:3729-3733.
22. Porjesz B, Begleiter H, Blangero J, Almasy L, Reich T (1997) QTL analysis of visual P3 component of the event-related brain potential in humans. Am J Med Genet 74:573a.
23. Prescott CA, Kendler KS (1999) Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am J Psychiatry 156:34-40.
24. Rodriguez LA, Wilson JR, Nagoshi CT (1993) Does psychomotor sensitivity to alcohol predict subsequent alcohol use? Alcohol Clin Exp Res 17:155-161.
25. Saccone NL, Kwon JM, Corbett J, Goate A, Rochberg N, Edenberg HJ, Foroud T, Li T-K, Begleiter H, Reich T, Rice JP (2001) A genome screen of maximum number of drinks as an alcoholism phenotype. Am J Med Genet 96:632-637.
26. Schuckit MA (2002) Vulnerability factors for alcoholism, in Neuropsychopharmacology: The Fifth Generation of Progress (Davis K ed), pp 1399-1411. Lippincott Williams & Wilkins, Philadelphia.
27. Schuckit MA, Edenberg HJ, Kalmijn J, Flury L, Smith TL, Reich T, Bierut L, Goate A, Foroud T (2001) A genome-wide search for genes that relate to a low level of response to alcohol. Alcohol Clin Exp Res 25:323-329.
28. Schuckit MA, Gold EO (1988) A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. Arch Gen Psychiatry 45:211-216.
29. Schuckit MA, Mazzanti C, Smith TL, Ahmed U, Radel M, Iwata N, Goldman D (1999) Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study. Biol Psychiatry 45:647-651.
30. Schuckit MA, Polich J, Gold EO, Croot K, Finn P (1983) P3 latency after ethanol in sons of alcoholics and controls. Biol Psychiatry 24:310-315.
31. Schuckit MA, Smith TL (1996) An 8-year follow-up of 450 sons of alcoholic and control subjects. Arch Gen Psychiatry 53:202-210.
32. Schuckit MA, Smith TL (2000) The relationships of a family history of alcohol dependence, a low level of response to alcohol and six domains of life functioning to the development of alcohol use disorders. J Stud Alcohol 61:827-835.
33. Schuckit MA, Smith TL, Kalmijn J, Raimo EB (2000) The relationship of a low response to alcohol to ERP and personality measures (abstract). Alcohol Clin Exp Res 24:27a.
34. Schuckit MA, Tipp JE, Smith TL, Wiesbeck GA, Kalmijn J (1997) The relationship between self-rating of the effects of alcohol and alcohol challenge results in ninety-eight young men. J Stud Alcohol 58:397-404.
35. Spitzer RL, Endicott J (1977) Schedule for Affective Disorders and Schizophrenia. New York State Psychiatric Institute, New York.
36. Sun F, Tsuritani I, Honda R, Ma ZY, Yamada Y (1999) Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. Hum Genet 105:295-300.
37. Upadhya SC, Tirumalai PS, Boyd MR, Mori T, Ravindranath V (2000) Cytochrome P4502E (CYP2E) in brain: constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization. Arch Biochem Biophys 373:23-34.
38. Vogel-Sprott M, Chipperfield B (1987) Family history of problem drinking among young male social drinkers: behavioral effects of alcohol. J Stud Alcohol 48:430-436.
39. Volavka J, Czobor P, Goodwin DW, Gabrielli WF Jr, Penick EC, Mednick SA, Jensen P, Knop J (1996) The electroencephalogram after alcohol administration in high-risk men and the development of alcohol use disorders 10 years later. Arch Gen Psychiatry 53:258-263.
40. Wall TL, Johnson ML, Horn SM, Carr LG, Smith TL, Schuckit MA (1999) Evaluation of the self-rating of the effects of alcohol form in Asian Americans with aldehyde dehydrogenase polymorphisms. J Stud Alcohol 60:784-789.
41. Weber JL, May PE (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 44:388-396.