An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project

Archives of General Psychiatry

Volumn 65, Issue 6, 2008, Pages 713-722

  Agrawal, Arpana ^a   Pergadia, Michele L ^a   Saccone, Scott F ^a   Lynskey, Michael T ^a   Wang, Jen C ^a   Martin, Nicholas G ^b   Statham, Dixie ^b   Henders, Anjali ^b   Campbell, Megan ^b   Garcia, Robertino ^a   Broms, Ulla ^c   Todd, Richard D ^a   Goate, Alison M ^a   Rice, John ^a   Kaprio, Jaakko ^c   Heath, Andrew C ^a   Montgomery, Grant W ^b   Madden, Pamela A F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR;

ARTICLE; AUSTRALIA; CANNABIS ADDICTION; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENETIC ANALYSIS; GENETIC LINKAGE; GENOTYPE; HUMAN; MALE; PHENOTYPE; TOBACCO DEPENDENCE;

ADULT; AUSTRALIA; CELL ADHESION MOLECULES, NEURONAL; CHROMOSOME ABERRATIONS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 4; CHROMOSOMES, HUMAN, PAIR 6; DISEASES IN TWINS; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOD SCORE; MALE; MARIJUANA ABUSE; MIDDLE AGED; NEUROPEPTIDES; PHENOTYPE; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GABA-A; TOBACCO USE DISORDER;

EID: 44649084982     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.65.6.713     Document Type: Article

References (63)

1. Stinson FS, Ruan WJ, Pickering R, Grant BF. Cannabis use disorders in the USA: prevalence, correlates and co-morbidity. Psychol Med. 2006;36(10):1447-1460.
2. Grant BF, Pickering R. The relationship between cannabis use and DSM-IV cannabis abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse. 1998;10(3):255-264.
3. Agrawal A, Lynskey MT. Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? results from the National Epidemiological Survey on Alcohol and Related Conditions. Drug Alcohol Depend. 2007;88(2-3):300-307.
4. Compton WM, Grant BF, Colliver JD, Glantz MD, Stinson FS. Prevalence of marijuana use disorders in the United States: 1991-1992 and 2001-2002. JAMA. 2004;291(17):2114-2121.
5. Substance Abuse and Mental Health Services Administration. The DASIS Report: Polydrug Use Among Treatment Admissions. Rockville, Md: Office of Applied Statistics, Substance Abuse and Mental Health Services Administration; 1998.
6. Ramaekers JG, Moeller MR, van Ruitenbeek P, Theunissen EL, Schneider E, Kauert G. Cognition and motor control as a function of δ-9-THC concentration in serum and oral fluid: limits of impairment. Drug Alcohol Depend. 2006;85(2):114-122.
7. Wadsworth EJ, Moss SC, Simpson SA, Smith AP. Cannabis use, cognitive performance and mood in a sample of workers. J Psychopharmacol. 2006;20(1):14-23.
8. Blows S, Ivers RQ, Connor J, Ameratunga S, Woodward M, Norton R. Marijuana use and car crash injury. Addiction. 2005;100(5):605-611.
9. Ramaekers JG, Berghaus G, van Laar M, Drummer OH. Dose-related risk of motor vehicle crashes after cannabis use. Drug Alcohol Depend. 2004;73(2):109-119.
10. Aldington S, Williams M, Nowitz M, Weatherall M, Pritchard A, McNaughton A, Robinson G, Beasley R. The effects of cannabis on pulmonary structure, function, and symptoms. Thorax. 2007;62(12):1036-1037.
11. Compton WM, Conway KP, Stinson FS, Colliver JD, Grant BF. Prevalence, correlates, and comorbidity of DSM-IV antisocial personality syndromes and alcohol and specific drug use disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2005;66(6):677-685.
12. Lynskey MT, Glowinski AL, Todorov AA, Bucholz KK, Madden PA, Nelson EC, Statham DJ, Martin NG, Heath AC. Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. Arch Gen Psychiatry. 2004;61(10):1026-1032.
13. Degenhardt L, Hall W, Lynskey M. Exploring the association between cannabis use and depression. Addiction. 2003;98(11):1493-1504.
14. Arseneault L, Cannon M, Poulton R, Murray R, Caspi A, Moffitt TE. Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. BMJ. 2002;325(7374):1212-1213.
15. Semple DM, McIntosh AM, Lawrie SM. Cannabis as a risk factor for psychosis: systematic review. J Psychopharmacol. 2005;19(2):187-194.
16. Patton GC, Coffey C, Carlin JB, Sawyer SM, Lynskey M. Reverse gateways? frequent cannabis use as a predictor of tobacco initiation and nicotine dependence. Addiction. 2005;100(10):1518-1525.
17. Timberlake DS, Haberstick BC, Hopfer CJ, Bricker J, Sakai JT, Lessem JM, Hewitt JK. Progression from marijuana use to daily smoking and nicotine dependence in a national sample of US adolescents. Drug Alcohol Depend. 2007;88(2-3):272-281.
18. Agrawal A, Lynskey M. The genetic epidemiology of cannabis use, abuse and dependence: a review. Addiction. 2006;101(6):801-812.
19. Hopfer CJ, Lessem JM, Hartman CA, Stallings MC, Cherny SS, Corley RP, Hewitt JK, Krauter KS, Mikulich-Gilbertson SK, Rhee SH, Smolen A, Young SE, Crowley TJ. A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: evidence for linkage on chromosomes 3 and 9. Drug Alcohol Depend. 2006;89(1):34-41.
20. Stallings MC, Corley RP, Dennehey B, Hewitt JK, Krauter KS, Lessem JM, Mikulich-Gilbertson SK, Rhee SH, Smolen A, Young SE, Crowley TJ. A genome-wide search for quantitative trait loci that influence antisocial drug dependence in adolescence. Arch Gen Psychiatry. 2005;62(9):1042-1051.
21. Stallings MC, Corley RP, Hewitt JK, Krauter KS, Lessem JM, Mikulich SK, Rhee SH, Smolen A, Young SE, Crowley TJ. A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence. Drug Alcohol Depend. 2003;70(3):295-307.
22. Agrawal A, Hinrichs A, Dunn G, Bertelsen S, Dick D, Saccone SF, Saccone NL, Grucza R, Wang JC, Cloninger CR, Edenberg H, Foroud T, Hesselbrock V, Kramer J, Bucholz K, Kuperman S, Nurnberger J, Porjesz B, Schuckit M, Goate A, Bierut L. Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample. Drug Alcohol Depend. 2008;93(1-2):12-20.
23. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
24. Lynskey MT, Agrawal A. Psychometric properties of DSM assessments of illicit drug abuse and dependence: results from the National Epidemiological Survey on Alcohol and Related Conditions. Psychol Med. 2007;37(9):1345-1355.
25. Gillespie NA, Neale MC, Prescott CA, Aggen SH, Kendler KS. Factor and item-response analysis of DSM-IV criteria for abuse and dependence on cannabis, cocaine, hallucinogens, sedatives, stimulants and opiates. Addiction. 2007;102(6):920-930.
26. Teesson M, Lynskey M, Manor B, Baillie A. The structure of cannabis dependence in the community. Drug Alcohol Depend. 2002;68(3):255-262.
27. Saccone SF, Pergadia ML, Loukola A, Broms U, Montgomery GW, Wang JC, Agrawal A, Dick DM, Heath AC, Todorov AA, Maunu H, Heikkila K, Morley KI, Rice JP, Todd RD, Kaprio J, Peltonen L, Martin NG, Goate AM, Madden PA. Genetic linkage to chromosome 22q12 for a heavy smoking quantitative trait in two independent samples. Am J Hum Genet. 2007;80(5):856-866.
28. Heath AC, Howells W, Kirk KM, Madden PA, Bucholz KK, Nelson EC, Slutske WS, Statham DJ, Martin NG. Predictors of non-response to a questionnaire survey of a volunteer twin panel: findings from the Australian 1989 twin cohort. Twin Res. 2001;4(2):73-80.
29. Heath AC, Meyer J, Jardine R, Martin NG. The inheritance of alcohol consumption patterns in a general population twin sample, II: determinants of consumption frequency and quantity consumed. J Stud Alcohol. 1991;52(5):425-433.
30. Bucholz KK, Cadoret RJ, Cloninger RC, Dinwiddie SH, Hesselbrock V, Nurnberger JI, Reich T, Schmidt I, Schuckit MA. New, semi-structured psychiatric interview for use in genetic linkage studies. J Stud Alcohol. 1994;55(2):149-158.
31. Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V. A validity study of the SSAGA: a comparison with the SCAN. Addiction. 1999;94(9):1361-1370.
32. World Health Organization. The Composite International Diagnostic Interview, version 1.1 (Researcher's Manual). Geneva, Switzerland: World Health Organization; 1994.
33. Boehnke M, Cox NJ. Accurate inference of relationships in sib-pair linkage studies. Am J Hum Genet. 1997;61(2):423-429.
34. Broman KW, Weber JL. Estimation of pairwise relationships in the presence of genotyping errors. Am J Hum Genet. 1998;63(5):1563-1564.
35. McPeek MS, Sun L. Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet. 2000;66(3):1076-1094.
36. Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, Hesselbrock V, Schuckit M, Almasy L, Porjesz B, Edenberg HJ, Begleiter H, Meyerhof W, Bierut LJ, Goate AM. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Hum Genet. 2006;78(1):103-111.
37. SAS Institute. SAS User Guide, version 8.2. Cary, NC: SAS Institute Inc; 1999.
38. Pritchard JK, Stephens M, Donnelly P. Inference of population structure using multilocus genotype data. Genetics. 2000;155(2):945-959.
39. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet. 2002;30(1):97-101.
40. Sham PC, Purcell S, Cherny SS, Abecasis GR. Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet. 2002;71(2):238-253.
41. Lynskey MT, Heath AC, Nelson EC, Bucholz KK, Madden PA, Slutske WS, Statham DJ, Martin NG. Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. Psychol Med. 2002;32(2):195-207.
42. North BV, Curtis D, Sham PC. A note on calculation of empirical P values from Monte Carlo procedure. Am J Hum Genet. 2003;72(2):498-499.
43. Adhikari P, Summerill A. 1998 National Drug Strategy Household Survey: Detailed Findings. Drug Statistics Series No. 6. Canberra, Australia: Australian Institute of Health and Welfare; 2000:22-23.
44. Bjarnadóttir TK, Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. 2004;84(1):23-33.
45. Entrez Gene: 2007. http://www.ncbi.nlm.nih.gov/sites/entrez?Db= gene&Cmd=ShowDetailView&TermToSearch=64123&ordinalpos=1&itool= EntrezSystem2.PEntr. Accessed April 8, 2008.
46. Nelson CB, Rehm J, Ustun TB, Grant B, Chatterji S. Factor structures for DSM-IV substance disorder criteria endorsed by alcohol, cannabis, cocaine and opiate users: results from the WHO reliability and validity study. Addiction. 1999;94(6):843-855.
47. Langenbucher JW, Labouvie EW, Martin C, Sanjuan PM, Bavly L, Kirisci L, Chung T. An application of item response theory analysis to alcohol, cannabis and cocaine criteria in DSM-IV. J Abnorm Psychol. 2004;113(1):72-80.
48. Budney AJ. Are specific dependence criteria necessary for different substances: how can research on cannabis inform this issue? Addiction. 2006;101(suppl 1):125-133.
49. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van EP, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, Porjesz B, Li TK, Conneally PM, Nurnberger JI Jr, Tischfield JA, Crowe RR, Cloninger CR, Wu W, Shears S, Carr K, Crose C, Willig C, Begleiter H. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet. 1998;81(3):207-215.
50. Agrawal A, Edenberg HJ, Foroud T, Bierut LJ, Dunne G, Hinrichs AL, Nurnberger JI, Crowe R, Kuperman S, Schuckit MA, Begleiter H, Porjesz B, Dick DM. Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet. 2006;36(5):640-650.
51. A receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet. 2004;74(4):705-714.
52. Fehr C, Sander T, Tadic A, Lenzen KP, Anghelescu I, Klawe C, Dahmen N, Schmidt LG, Szegedi A. Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatr Genet. 2006;16(1):9-17.
53. Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR. Allelic and haplotypic association of GABRA2 with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet. 2004;129(1):104-109.
54. Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, Somberg LK, Covault J, Kranzler HR, Krystal JH, Gelernter J. Association between alcoholism and γ-amino butyric acid α2 receptor subtype in a Russian population. Alcohol Clin Exp Res. 2005;29(4):493-498.
55. Dick DM, Bierut LJ, Hinrichs AL, Fox L, Bucholz K, Kramer JR, Kuperman S, Hesselbrock M, Schuckit M, Almasy L, Tischfield JA, Porjesz B, Begleiter H, Nurnberger JI, Xuei X, Edenberg HJ, Foroud T. The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across different developmental stages [published online ahead of print March 24, 2006]. Behav Genet. 2006;36(4):577-590. doi:10.1007/s10519-005-9041-8.
56. Zhang PW, Ishiguro H, Ohtsuki T, Hess J, Carillo F, Walther D, Onaivi ES, Arinami T, Uhl GR. Human cannabinoid receptor 1: 5′ exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. Mol Psychiatry. 2004;9(10):916-931.
57. Aguado T, Monory K, Palazuelos J, Stella N, Cravatt B, Lutz B, Marsicano G, Kokaia Z, Guzman M, Galve-Roperh I. The endocannabinoid system drives neural progenitor proliferation. FASEB J. 2005;19(12):1704-1706.
58. Gong C, Wang TW, Huang HS, Parent JM. Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus. J Neurosci. 2007;27(8):1803-1811.
59. Wedenoja J, Loukola A, Tuulio-Henriksson A, Paunio T, Ekelund J, Silander K, Varilo T, Heikkila K, Suvisaari J, Partonen T, Lonnqvist J, Peltonen L. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families [published online ahead of print August 7, 2007]. Mol Psychiatry. doi:10.1038/sj.mp.4002047.
60. Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H, Taylor A, Arseneault L, Williams B, Braithwaite A, Poulton R, Craig IW. Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene x environment interaction. Biol Psychiatry. 2005;57(10):1117-1127.
61. Budney AJ, Moore BA, Vandrey RG, Hughes JR. The time course and significance of cannabis withdrawal. J Abnorm Psychol. 2003;112(3):393-402.
62. Budney AJ, Hughes JR, Moore BA, Vandrey R. Review of the validity and significance of cannabis withdrawal syndrome. Am J Psychiatry. 2004;161(11):1967-1977.
63. Budney AJ, Hughes JR. The cannabis withdrawal syndrome. Curr Opin Psychiatry. 2006;19(3):233-238.