Activation instead of inhibition: Targeting proenzymes for small-molecule intervention

ChemBioChem

Volumn 11, Issue 5, 2010, Pages 637-639

  Ottmann, Christian ^a   Hauske, Patrick ^a   Kaiser, Markus ^a  

^a CHEMICAL GENOMICS CENTRE OF THE MAX PLANCK SOCIETY   (Germany)

Author keywords

Allosterism; Chemical biology; Enzyme activation; Medicinal chemistry; Small molecules

Indexed keywords

CASPASE 3; CASPASE 6; ENZYME INHIBITOR; PROTEINASE;

CONFORMATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; PRIORITY JOURNAL; SHORT SURVEY; STRUCTURE ACTIVITY RELATION;

BENZAMIDES; CASPASE 3; CATALYTIC DOMAIN; COUMARINS; ENZYME PRECURSORS; HYDRAZONES; PIPERAZINES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 77949818355     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000024     Document Type: Short Survey

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