Interventions for prevention of post-operative recurrence of Crohn's disease

Cochrane Database of Systematic Reviews

Volumn , Issue 4, 2009, Pages

  Doherty, Glen ^a   Bennett, Gayle ^a   Patil, Seema ^a   Cheifetz, Adam ^a   Moss, Alan C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Anti inflammatory agents, non steroidal *therapeutic use ; Crohn disease *prevention control; surgery ; Humans; Immunosuppressive agents *therapeutic use ; Nitroimidazoles adverse effects; *therapeutic use ; Postoperative complications *prevention control ; Probiotics therapeutic use ; Randomized controlled trials as topic; Recurrence prevention control

Indexed keywords

AZATHIOPRINE; BUDESONIDE; INFLIXIMAB; INTERLEUKIN 10; MERCAPTOPURINE; MESALAZINE; NITROIMIDAZOLE DERIVATIVE; PLACEBO; PROBIOTIC AGENT; RECOMBINANT INTERLEUKIN 10;

CLINICAL TRIAL; CROHN DISEASE; DRUG EFFICACY; HUMAN; INTERVENTION STUDY; INTESTINE ENDOSCOPY; PROPHYLAXIS; RECURRENT DISEASE; REVIEW; SYSTEMATIC REVIEW; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

EID: 77949770445     PISSN: 1469493X     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD006873.pub2     Document Type: Review

References (125)

1. Ardizzone 2004 {published data only} Ardizzone S, Maconi G, Sampietro GM, Russo A, Radice E, Colombo E, et al.Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease. Gastroenterology 2004;127(3):730-40.
2. Brignola 1995 {published data only} Brignola C, Cottone M, Pera A, Ardizzone S, Scribano ML, De Franchis R, et al.Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease. Italian Cooperative Study Group. Gastroenterology 1995;108(2):345-9.
3. Caprilli 2003 {published data only} Caprilli R, Cottone M, Tonelli F, Sturniolo G, Castiglione F, Annese V, et al.Two mesalazine regimens in the prevention of the post-operative recurrence of Crohn's disease: a pragmatic, doubleblind, randomized controlled trial. Aliment Pharmacol Ther 2003;17(4):517-23.
4. Chermesh 2007 {published data only} Chermesh I, Tamir A, Reshef R, Chowers Y, Suissa A, Katz D, et al.Failure of Synbiotic 2000 to prevent postoperative recurrence of Crohn's disease. Dig Dis Sci 2007;52(2):385-9.
5. Colombel 2001 {published data only} Colombel JF, Rutgeerts P, Malchow H, Jacyna M, Nielsen OH, Rask-Madsen J, et al.Interleukin 10 (Tenovil) in the prevention of postoperative recurrence of Crohn's disease. Gut 2001 2001;49(1):42-6.
6. D'Haens 2008 {published data only} D'Haens GR, Vermeire S, Van Assche G, Noman M, Aerden I, Van Olmen G, et al.Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial. Gastroenterology 2008;135(4):1123-9.
7. Ewe 1989 {published data only} Ewe K, Herfarth C, Malchow H, Jesdinsky HJ. Postoperative recurrence of Crohn's disease in relation to radicality of operation and sulfasalazine prophylaxis: a multicenter trial. Digestion 1989;42(4):224-32.
8. Ewe 1999 {published data only} Ewe K, Bottger T, Buhr HJ, Ecker KW, Otto HF. Low-dose budesonide treatment for prevention of postoperative recurrence of Crohn's disease: a multicentre randomized placebo-controlled trial. German Budesonide Study Group. Eur J Gastroenterol Hepatol 1999;11(3):277-82.
9. Fiasse 1991 {published data only} Fiasse R, Fontaine F, Vanheuverzwyn R. Prevention of Crohn's disease recurrences after intestinal resection with Eudragid-L-coated 5-aminosalicylic acid. Preliminary results of a one year double-blind placebo controlled study. Gastroenterology 1991;100(5 Part 2):A208.
10. Florent 1996 {published data only} Florent C, Cortot A, Quandale P, Sahmound T, Modigliani R, Sarfaty E, et al.Placebo-controlled clinical trial of mesalazine in the prevention of early endoscopic recurrences after resection for Crohn's disease. Groupe d'Etudes Therapeutiques des Affections Inflammatoires Digestives (GETAID). Eur J Gastroenterol Hepatol 1996;8(3):229-33.
11. Hanauer 2004 {published data only} Hanauer SB, Korelitz BI, Rutgeerts P, Peppercorn MA, Thisted RA, Cohen RD, et al.Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. Gastroenterology 2004;127(3):723-9.
12. Hellers 1999 {published data only} Hellers G, Cortot A, Jewell D, Leijonmarck CE, Lofberg R, Malchow H, et al.Oral budesonide for prevention of postsurgical recurrence in Crohn's disease. The IOIBD Budesonide Study Group. Gastroenterology 1999;116(2):294-300.
13. Herfarth 2006 {published and unpublished data} Herfarth H, Tjaden C, Lukas M, Obermeier F, Dilger K, Müller R, Schölmerich J. Adverse events in clinical trials with azathioprine and mesalamine for prevention of postoperative recurrence of Crohn's disease.. Gut 2006;55(10):1525-6.
14. Lochs 2000 {published data only} Lochs H, Mayer M, Fleig WE, Mortensen PB, Bauer P, Genser D, et al.Prophylaxis of postoperative relapse in Crohn's disease with mesalamine: European Cooperative Crohn's Disease Study VI. Gastroenterology 2000;118(2):264-73.
15. Madsen 2008 {published data only} Madsen K, Backer JL, Leddin D, Dieleman LA, Bitton A, Feagan B, et al.A randomized controlled trial of VSL#3 for the prevention of endoscopic recurrence following surgery for Crohn's disease. Gastroenterology 2008;134(4 Suppl 1):A361.
16. Marteau 2006 {published data only} Marteau P, Lemann M, Seksik P, Laharie D, Colombel JF, Bouhnik Y, et al.Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial. Gut 2006;55(6):842-7.
17. McLeod 1995 {published data only} McLeod RS, Wolff BG, Steinhart AH, Carryer PW, O'Rourke K, Andrews DF, et al.Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease. Gastroenterology 1995;109(2):404-13.
18. Nos 2000 {published data only} Nos P, Hinojosa J, Aguilera V, Moles JR, Pastor M, Ponce J, et al.[Azathioprine and 5-ASA in the prevention of postoperative recurrence of Crohn's disease]. Gastroenterol Hepatol 2000;23(8):374-8.
19. Prantera 2002 {published data only} Prantera C, Scribano ML, Falasco G, Andreoli A, Luzi C. Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: a randomised controlled trial with Lactobacillus GG. Gut 2002;51(3):405-9.
20. Regueiro 2009 {published data only} Regueiro M, Schraut W, Baidoo L, Kip K, Sepulveda A, PasciM, Harrison J, Plevy S. Infliximab prevents Crohn's disease recurrence after ileal resection. Gastroenterology 2009;136(2):441-50.
21. Rutgeerts 1995 {published data only} Rutgeerts P, Hiele M, Geboes K, Peeters M, Penninckx F, Aerts R, et al.Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection. Gastroenterology 1995;108 (6):1617-21.
22. Rutgeerts 2005 {published data only} Rutgeerts P, Van Assche G, Vermeire S, D'Haens G, Baert F, Noman M, et al.Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology 2005;128(4):856-61.
23. Van Gossum 2007 {published data only} Van Gossum A, Dewit O, Louis E, de Hertogh G, Baert F, Fontaine F, et al.Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection. Inflamm Bowel Dis 2007;13(2):135-42.
24. Abdelli 2007 {published data only} Abdelli MN, Ben Abdallah H, Houissa F, Bouali MR, Khediri MF. [Azathioprine for prevention of postoperative recurrence in Crohn's disease]. Tunis Med 2007;85(7):569-72.
25. Achkar 2000 {published data only} Achkar JP, Hanauer SB. Medical therapy to reduce postoperative Crohn's disease recurrence. Am J Gastroenterol 2000;95(5):1139-46.
26. Achkar 2001 {published data only} Achkar JP, Shen B. Medical management of postoperative complications of inflammatory bowel disease: pouchitis and Crohn's disease recurrence. Curr Gastroenterol Rep 2001;3(6):484-90.
27. Alves 2004 {published data only} Alves A, Panis Y, Joly F, Pocard M, Lavergne-Slove A, Bouhnik Y, et al.Could immunosuppressive drugs reduce recurrence rate after second resection for Crohn disease?. Inflamm Bowel Dis 2004;10(5):491-5.
28. Ambrose 1985 {published data only} Ambrose NS, Allan RN, Keighley MR, Burdon DW, Youngs D, Barnes P, et al.Antibiotic therapy for treatment in relapse of intestinal Crohn's disease. A prospective randomized study. Dis Colon Rectum 1985;28(2):81-5.
29. Ardizzone 2003 {published data only} Ardizzone S, Bollani S, Manzionna G, Colombo E, Maconi G, Imbesi V, et al.[Efficacy of medical therapy in preventing the postsurgical recurrence in Crohn's disease]. Ann Ital Chir 2003;74(6):621-5.
30. Bakkevold 2000 {published data only} Bakkevold KE. Nipple valve anastomosis for preventing recurrence of Crohn disease in the neoterminal ileum after ileocolic resection. A prospective pilot study. Scand J Gastroenterol 2000;35(3):293-9.
31. Belluzzi 1996 {published data only} Belluzzi A, Brignola C, Campieri M, Pera A, Boschi S, Miglioli M. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. N Engl J Med 1996;334(24):1557-60.
32. Bemelman 2001 {published data only} Bemelman WA, Ivenski M, van Hogezand RA, Hermans J, Veenendaal RA, Griffioen G. How effective is extensive nonsurgical treatment of patients with clinically active Crohn's disease of the terminal ileum in preventing surgery?. Dig Surg 2001;18(1):50-60.
33. Berebbi 1993 {published data only} Berrebi W, Chaussade S, Bruhl AL, Pariente A, Valleur P, Hautefeuille P, et al.Treatment of Crohn's disease recurrence after ileoanal anastomosis by azathioprine. Dig Dis Sci 1993;38(8):1558-60.
34. Bergman 1976 {published data only} Bergman L, Krause U. Postoperative treatment with corticosteroids and salazosulphapyridine (Salazopyrin) after radical resection for Crohn's disease.. Scand J Gastroenterol 1976;11(7):651-6.
35. Biancone 2006 {published data only} Biancone L, Cretella M, Tosti C, Palmieri G, Petruzziello C, Geremia A, et al.Local injection of infliximab in the postoperative recurrence of Crohn's disease. Gastrointest Endosc 2006;63(3):486-92.
36. Blumberg 1990 {published data only} Blumberg N, Triulzi DJ, Heal JM. Transfusion-induced immunomodulation and its clinical consequences. Transfus Med Rev 1990;4(4 Suppl 1):24-35.
37. Borley 1997 {published data only} Borley NR, Mortensen NJ, Jewell DP. Preventing postoperative recurrence of Crohn's disease. Br J Surg 1997;84(11):1493-502.
38. Cameron 1992 {published data only} Cameron JL, Hamilton SR, Coleman J, Sitzmann JV, Bayless TM. Patterns of ileal recurrence in Crohn's disease. A prospective randomized study. Ann Surg 1992;215(5):546- 51.
39. Caprilli 1994 {published data only} Caprilli R, Andreoli A, Capurso L, Corrao G, D'Albasio G, Gioieni A, et al.Oral mesalazine (5-aminosalicylic acid; Asacol) for the prevention of post-operative recurrence of Crohn's disease. Gruppo Italiano per lo Studio del Colon e del Retto (GISC). Aliment Pharmacol Ther 1994;8(1):35-43.
40. Caprilli 1996 {published data only} Caprilli R, Corrao G, Taddei G, Tonelli F, Torchio P, Viscido A. Prognostic factors for postoperative recurrence of Crohn's disease. Gruppo Italiano per lo Studio del Colon e del Retto (GISC). Dis Colon Rectum 1996;39(3):335-41.
41. Cottone 2003 {published data only} Cottone M, Orlando A, Viscido A, Calabrese E, Cammà C, Casà A. Review article: prevention of postsurgical relapse and recurrence in Crohn's disease. Aliment Pharmacol Ther 2003;17 Suppl 2:38-42.
42. Cuillerier 2001 {published data only} Cuillerier E, Lémann M, Bouhnik Y, Allez M, Rambaud JC, Modigliani R. Azathioprine for prevention of postoperative recurrence in Crohn's disease: a retrospective study. Eur J Gastroenterol Hepatol 2001;13(11):1291-6.
43. D'Haens 1999a {published data only} D'Haens G. Prevention of postoperative recurrence in Crohn's disease. Curr Gastroenterol Rep 1999;1(6):476-81.
44. D'Haens 1999b {published data only} D'Haens G, Rutgeerts P. Postoperative recurrence of Crohn's disease: pathophysiology and prevention. Inflamm Bowel Dis 1999;5(4):295-303.
45. de Jong 2007 {published data only} de Jong DJ, Bac DJ, Tan G, de Boer SY, Grabowsky IL, Jansen JB, et al.Maintenance treatment with budesonide 6 mg versus 9 mg once daily in patients with Crohn's disease in remission. Neth J Med 2007;65(9):339-45.
46. Dirks 1989 {published data only} Dirks E, Goebell H, Schaarschmidt K, Förster S, Quebe-Fehling E, Eigler FW. Clinical relapse of Crohn's disease under standardized conservative treatment and after excisional surgery. Dig Dis Sci 1989;34(12):1832-40.
47. Domenech 2004 {published data only} Domènech E, Scala L, Bernal I, García-Planella E, Casalots A, Piñol M, et al.[Azathioprine and mesalazine in the prevention of postsurgical recurrence of Crohn's disease: a retrospective study]. Gastroenterol Hepatol 2004;27(10):563-7.
48. Domenech 2008 {published data only} Domènech E, Mañosa M, Bernal I, Garcia-Planella E, Cabré E, Piñol M, et al.Impact of azathioprine on the prevention of postoperative Crohn's disease recurrence: results of a prospective, observational, long-term follow-up study. Inflamm Bowel Dis 2008;14(4):508-13.
49. Ellis 2006 {published data only} Ellis CN, Clark S. Fibrin glue as an adjunct to flap repair of anal fistulas: a randomized, controlled study. Dis Colon Rectum 2006;49(11):1736-40.
50. Esaki 2005 {published data only} Esaki M, Matsumoto T, Hizawa K, Nakamura S, Jo Y, Mibu R, et al.Preventive effect of nutritional therapy against postoperative recurrence of Crohn disease, with reference to findings determined by intra-operative enteroscopy. Scand J Gastroenterol 2005;40(12):1431-7.
51. Ewe 1976 {published data only} Ewe K, Holtermüller KH, Baas U, Eckhart V, Krieg H, Kutzner J, et al.[Prevention of recurrence by salazosulfapyridine (azulfidine) therapy in Crohn's disease. A double blind study]. Verh Dtsch Ges Inn Med 1976;82 Pt 1:930-2.
52. Ewe 1980 {published data only} Ewe K, Herfarth C, Malchow H. [Surgical and internal medicine therapy study of the postoperative prevention of recurrence in Crohn's disease - completion of a partly randomized study]. Verh Dtsch Ges Inn Med 1980;86:1327-37.
53. Ewe 1981 {published data only} Ewe K. [Effectiveness of Azulfidine/Salazopyrin in the postoperative prevention of recurrence in Crohn disease]. Z Gastroenterol Verh 1981;19:41-4.
54. Ewe 1984 {published data only} Ewe K, Malchow H, Herfarth C. [Radical operation and recurrence prevention with azulfidine in Crohn disease: a prospective multicenter study - initial results]. Langenbecks Arch Chir 1984;364:427-30.
55. Fazio 1996 {published data only} Fazio VW, Marchetti F, Church M, Goldblum JR, Lavery C, Hull TL, et al.Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial. Ann Surg 1996;224(4):563-71.
56. Feagan 1994 {published data only} Feagan BG, McDonald JW, Rochon J, Laupacis A, Fedorak RN, Kinnear D, et al.Low-dose cyclosporine for the treatment of Crohn's disease. The Canadian Crohn's Relapse Prevention Trial Investigators. N Engl J Med 1994;330(26):1846-51.
57. Feagan 2003 {published data only} Feagan BG. Maintenance therapy for inflammatory bowel disease. Am J Gastroenterol 2003;98(12 Suppl):S6-S17.
58. Fedorak 2000 {published data only} Fedorak RN, Gangl A, Elson CO, Rutgeerts P, Schreiber S,Wild G, et al.Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group. Gastroenterology 2000;119(6):1473-82.
59. Froehlich 2005 {published data only} Froehlich F, Juillerat P, Felley C, Mottet C, Vader JP, Burnand B, et al.Treatment of postoperative Crohn's disease. Digestion 2005;71(1):49-53.
60. Garcia 2001 {published data only} Garcia JC, Persky SE, Bonis PA, Topazian M. Abscesses in Crohn's disease: outcome of medical versus surgical treatment. J Clin Gastroenterol 2001;32(5):409-12.
61. Gardiner 2007 {published data only} Gardiner KR, Dasari BV. Operative management of small bowel Crohn's disease. Surg Clin North Am 2007;87(3):587-610.
62. Ghidirim 2007 {published data only} Ghidirim G, Ignatenco S, Misin I, Gagauz I, Tiple I, Cutitari I, et al.[Recurrent Crohn's disease in the ileocolonic anastomosis complicated with duodenal fistula]. Chirurgia (Bucur) 2007;102(5):607-10.
63. Gooszen 1994 {published data only} Gooszen HG, Silvis R. Protective effect of blood transfusions on postoperative recurrence of Crohn's disease in parous women. Neth J Med 1994;45(2):65-71.
64. Gross 1995 {published data only} Gross V, Andus T, Schölmerich J. [Crohn disease: prevention and drug therapy]. Chirurg 1995;66(8):757-63.
65. Hamedani 1997 {published data only} Hamedani R, Feldman RD, Feagan BG. Review article: Drug development in inflammatory bowel disease: budesonide - a model of targeted therapy. Aliment Pharmacol Ther 1997;11 Suppl 3:98-107.
66. Hanauer 2003 {published data only} Hanauer SB. Crohn's disease: step up or top down therapy. Best Pract Res Clin Gastroenterol 2003;17(1):131-7.
67. Hancock 2006 {published data only} Hancock L, Windsor AC, Mortensen NJ. Inflammatory bowel disease: the view of the surgeon. Colorectal Dis 2006;8 Suppl 1:10-4.
68. Ikeuchi 2000 {published data only} Ikeuchi H, Kusunoki M, Yamamura T. Long-term results of stapled and hand-sewn anastomoses in patients with Crohn's disease. Dig Surg 2000;17(5):493-6.
69. Kader 1997 {published data only} Kader HA, Raynor SC, Young R, Kaufman SS, Vanderhoof J, Ruby EI, et al.Introduction of 6-mercaptopurine in Crohn's disease patients during the perioperative period: a preliminary evaluation of recurrence of disease. J Pediatr Gastroenterol Nutr 1997;25(1):93-7.
70. Kennedy 1998 {published data only} Kennedy ED, Blair JE, Ready R, Wolff BG, Steinhart AH, Carryer PW, et al.Patients' perceptions of their participation in a clinical trial for postoperative Crohn's disease. Can J Gastroenterol 1998;12(4):287-91.
71. Klein 1995 {published data only} Klein O, Colombel JF, Lescut D, Gambiez L, Desreumaux P, Quandalle P, et al.Remaining small bowel endoscopic lesions at surgery have no influence on early anastomotic recurrences in Crohn's disease. Am J Gastroenterol 1995;90(11):1949-52.
72. Koop 1994 {published data only} Koop I. [Is preventive drug therapy of recurrent Crohn disease indicated after ileocecal resection?]. Internist (Berl) 1994;35(2):192.
73. Korelitz 1998 {published data only} Korelitz B, Hanauer S, Rutgeerts P, Present D, Peppercorn M. Post-operative prophylaxis with 6-MP, 5-ASA or placebo in Crohn's disease: A 2 year multicenter trial. Gastroenterology 1998;114:A1011.
74. Kusunoki 1998 {published data only} Kusunoki M, Ikeuchi H, Yanagi H, Shoji Y, Yamamura T. A comparison of stapled and hand-sewn anastomoses in Crohn's disease. Dig Surg 1998;15(6):679-82.
75. Lemann 2006a {published data only} Lémann M. Review article: can post-operative recurrence in Crohn's disease be prevented?. Aliment Pharmacol Ther 2006;24 Suppl 3:22-8.
76. Lemann 2006b {published data only} Lémann M, Mary JY, Duclos B, Veyrac M, Dupas JL, Delchier JC, et al.Infliximab plus azathioprine for steroid-dependent Crohn's disease patients: a randomized placebo-controlled trial. Gastroenterology 2006;130(4):1054-61.
77. Levenstein 1985 {published data only} Levenstein S, Prantera C, Luzi C, D'Ubaldi A. Low residue or normal diet in Crohn's disease: a prospective controlled study in Italian patients. Gut 1985;26(10):989-93.
78. MacDonald 2006 {published data only} Macdonald A. Omega-3 fatty acids as adjunctive therapy in Crohns disease. Gastroenterol Nurs 2006;29(4):295-301.
79. Mahmud 2001 {published data only} Mahmud N, Kamm MA, Dupas JL, Jewell DP, O'Morain CA, Weir DG, et al.Olsalazine is not superior to placebo in maintaining remission of inactive Crohn's colitis and ileocolitis: a double blind, parallel, randomised, multicentre study. Gut 2001;49(4):552-6.
80. Mamula 2000 {published data only} Mamula P, Baldassano RN. Postsurgical recurrences in Crohn's disease: why, when and how to prevent them. J Pediatr Gastroenterol Nutr 2000;30(5):557-9.
81. McIntyre 1986 {published data only} McIntyre PB, Powell-Tuck J, Wood SR, Lennard-Jones JE, Lerebours E, Hecketsweiler P, et al.Controlled trial of bowel rest in the treatment of severe acute colitis. Gut 1986;27(5):481-5.
82. McLeod 1996 {published data only} Mcleod RS. Is it possible to prevent recurrent Crohn's disease with medical or surgical interventions?. Neth J Med 1996;48(2):68-70.
83. Mekhijan 1979 {published data only} Mekhjian HS, Switz DM, Melnyk CS, Rankin GB, Brooks RK. Clinical features and natural history of Crohn's disease. Gastroenterology 1979;77(4 Pt 2):898-906.
84. Morretini 1981 {published data only} Morettini A, Scartabelli S, Bechi P, Bartolozzi C, Taddei GL, Bartoletti L, et al.[Evaluation of the results of radical surgical treatment of Crohn disease as related to a diversified postoperative treatment]. Recenti Prog Med 1981;70(6):669-73.
85. Myrelid 2006 {published data only} Myrelid P, Svärm S, Andersson P, Almer S, Bodemar G, Olaison G. Azathioprine as a postoperative prophylaxis reduces symptoms in aggressive Crohn's disease. Scand J Gastroenterol 2006;41(10):1190-5.
86. O'Brien 1991 {published data only} O'Brien CJ, Giaffer MH, Cann PA, Holdsworth CD. Elemental diet in steroid-dependent and steroid-refractory Crohn's disease. Am J Gastroenterol 1991;86(11):1614-8.
87. Prantera 1999 {published data only} Prantera C, Scribano ML. Current treatment for prevention of relapse and recurrence in Crohn's disease. Ital J Gastroenterol Hepatol 1999;31(6):515-8.
88. Qasim 2001 {published data only} Qasim A, Seery J, O'Morain CA. Aminosalicylate as prophylaxis for Crohn's disease. Gut 2001;49(6):873.
89. Regimbeau 1999 {published data only} Régimbeau JM, Panis Y, Marteau P, Benoist S, Valleur P. Surgical treatment of anoperineal Crohn's disease: can abdominoperineal resection be predicted?. J Am Coll Surg 1999;189(2):171-6.
90. Reinisch 2008 {published data only} Reinisch W, Angelberger S, Petritsch W, Herrlinger K, Shonova O, Lukas M, et al.A Double-Blind, Double-Dummy, Randomized, Controlled, Multicenter Trial On the Efficacy and Safety of Azathioprine Vs mesalamine for Prevention of Clinical Relapses in Crohn's Disease Patients with Postoperative Moderate or Severe Endoscopic Recurrence. Gastroenterology 2008;134(4 Suppl 1):A70.
91. Rutgeerts 2003 {published data only} Rutgeerts P. Strategies in the prevention of post-operative recurrence in Crohn's disease. Best Pract Res Clin Gastroenterol 2003;17(1):63-73.
92. Ryan 2004 {published data only} Ryan WR, Allan RN, Yamamoto T, Keighley MR. Crohn's disease patients who quit smoking have a reduced risk of reoperation for recurrence. Am J Surg 2004;187(2):219-25.
93. Sandborn 2004 {published data only} Sandborn WJ, Feagan BG. The efficacy of azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in patients with Crohn's disease remains uncertain. Gastroenterology 2004;127(3):990-3.
94. Scarpa 2007 {published data only} Scarpa M, Ruffolo C, Bertin E, Polese L, Filosa T, Prando D, et al.Surgical predictors of recurrence of Crohn's disease after ileocolonic resection. Int J Colorectal Dis 2007;22(9):1061-9.
95. Seibold 2003 {published data only} Seibold F. [Does conservative therapy of chronic inflammatory bowel diseases still play a role?]. Swiss Surg 2003;9(3):127-30.
96. Sninsky 2001 {published data only} Sninsky CA. Altering the natural history of Crohn's disease?. Inflamm Bowel Dis 2001;7 Suppl 1:S34-9.
97. Sorrentino 2006 {published data only} Sorrentino D, Terrosu G, Avellini C, Beltrami CA, Bresadola V, Toso F. Prevention of postoperative recurrence of Crohn's disease by infliximab. Eur J Gastroenterol Hepatol 2006;18(4):457-9.
98. Sorrentino 2007 {published data only} Sorrentino D, Terrosu G, Avellini C, Maiero S. Infliximab with low-dose methotrexate for prevention of postsurgical recurrence of ileocolonic Crohn disease. Arch Intern Med 2007;167(16):1804-7.
99. Stein 1999 {published data only} Stein RB, Hanauer SB. Medical therapy for inflammatory bowel disease. Gastroenterol Clin North Am 1999;28(2):297-321.
100. Steinhart 1992 {published data only} Steinhart AH, O'Rourke K, Wolff BG, McLeod RS. Application of a stopping rule based on total treatment failures: the postoperative Crohn's disease trial. J Clin Epidemiol 1992;45(5):495-504.
101. Steinhart 2007 {published data only} Steinhart AH, Forbes A, Mills EC, Rodgers-Gray BS, Travis SP. Systematic review: the potential influence of mesalazine formulation on maintenance of remission in Crohn's disease. Aliment Pharmacol Ther 2007;25(12):1389-99.
102. Sutherland 2000 {published data only} Sutherland LR. Prevention of relapse of Crohn's disease. Inflamm Bowel Dis 2000;6(4):321-8.
103. Tay 2003 {published data only} Tay GS, Binion DG, Eastwood D, Otterson MF. Multivariate analysis suggests improved perioperative outcome in Crohn's disease patients receiving immunomodulator therapy after segmental resection and/or strictureplasty. Surgery 2003;134(4): 565-72.
104. Travis 2001 {published data only} Travis S. Azathioprine for prevention of postoperative recurrence in Crohn's disease. Eur J Gastroenterol Hepatol 2001;13(11):1277-9.
105. Van Assche 2004 {published data only} Van Assche G, Rutgeerts P. Medical management of postoperative recurrence in Crohn's disease. Gastroenterol Clin North Am 2004;33 (2):347-60.
106. Van Hogezand 1998 {published data only} van Hogezand RA, Bemelman WA. Management of recurrent Crohn's disease. Neth J Med 1998;53(6):S32-8..
107. Viscido 1999 {published data only} Viscido A, Corrao G, Taddei G, Caprilli R. "Crohn's disease activity index" is inaccurate to detect the post-operative recurrence in Crohn's disease. A GISC study. Gruppo Italiano per lo Studio del Colon e del Retto. Ital J Gastroenterol Hepatol 1999;31(4):274-9.
108. Volk-Zeiher 1998 {published data only} Volk-Zeiher BA, Blum HE. [Therapy of Crohn disease in internal medicine: postoperative recurrence and fistulas]. Praxis (Bern 1994) 1998;87(48):1657-60.
109. Yamamoto 2005 {published data only} Yamamoto T. Factors affecting recurrence after surgery for Crohn's disease. World J Gastroenterol 2005;11(26):3971-9.
110. Yamamoto 2007 {published data only} Yamamoto T, Nakahigashi M, Umegae S, Kitagawa T, Matsumoto K. Impact of long-term enteral nutrition on clinical and endoscopic recurrence after resection for Crohn's disease: A prospective, non-randomized, parallel, controlled study. Aliment Pharmacol Ther 2007;25(1):67-72.
111. Akobeng 2005 Akobeng AK, Gardener E. Oral 5-aminosalicylic acid for maintenance of medically-induced remission inCrohn's Disease.. Cochrane Database Syst Rev. 2005;1:CD003715.
112. Bernell 2000 Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn's disease. Ann Surg 2000;231(1):38-45.
113. Delaney 2003 Delaney CP, Kiran RP, Senagore AJ, O'Brien-Ermlich B, Church J, Hull TL, et al.Quality of life improves within 30 days of surgery for Crohn's disease. J Am Coll Surg 2003;196(5):714-21.
114. Higgins 2008 Higgins JPT, Altman DG (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
115. Jadad 1996 Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blindingnecessary?. Control Clin Trials. 1996;17(1):1-12.
116. Larson 2004 Larson DW, Pemberton JH. Current conceps and controversies in surgery for IBD. Gastroenterology 2004;126(6): 1611-9.
117. Olaison 1992 Olaison G, Smedh K, Sjödahl R. Natural course of Crohn's disease after ileocolic resection: endoscopically visualized ileal ulcers preceding symptoms. Gut 1992;33(3):331-5.
118. Otley 2005 Otley A, Steinhart AH. Budesonide for induction of remission in Crohn's disease. Cochrane Database Syst Rev. 2005;4:CD000296.
119. Peyrin-Biroulet 2009 Peyrin-Biroulet L, Deltenre P, Ardizzone S, D'Haens G, Hanauer SB, Herfarth H, Lémann M, Colombel JF. Azathioprine and 6-Mercaptopurine for the Prevention of Postoperative Recurrence in Crohn's Disease: A Meta-Analysis.. Am J Gastroenterol 2009;104 (8):2089-96.
120. Prefontaine 2009 Prefontaine E, Sutherland LR, Macdonald JK, Cepoiu M. Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease.. Cochrane Database Syst Rev. 2009;1:CD000067.
121. Regueiro 2009 Regueiro M, Schraut W, Baidoo L, Kip KE, Sepulveda AR, Pesci M, et al.Infliximab prevents Crohn's disease recurrence after ileal resection. Gastroenterology 2009;136(2):441-50.
122. Rutgeerts 1984 Rutgeerts P, Geboes K, Vantrappen G, Kerremans R, Coenegrachts JL, Coremans G. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis aftercurative surgery.. Gut 1984;25(6): 665-72.
123. Rutgeerts 1990 Rutgeerts P, Geboes K, Vantrappen G, Beyls J, Kerremans R, Hiele M. Predictability of the postoperative course of Crohn's disease. Gastroenterology 1990;99(4):956-63.
124. Sokol 2008 Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottière HM, Doré J, Marteau P, Seksik P, Langella P. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacteriumidentified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 2008;105(43):16731-6.
125. Travis 2006 Travis SP, Stange EF, Lémann M, Oresland T, Chowers Y, Forbes A, et al.European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut 2006; 55 Suppl 1:i16-35.