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Volumn 9, Issue 8, 2010, Pages 1115-1121

Increasing trend of metronidazole resistance in the treatment of Helicobacter pylori infection: A global challenge

Author keywords

Drug resistance; Gene mutations; Helicobacter pylori; Metronidazole; Public health

Indexed keywords

AMOXICILLIN; BISMUTH SALICYLATE; CLARITHROMYCIN; METRONIDAZOLE; NITROREDUCTASE; OXYGEN; PROTON PUMP INHIBITOR; TETRACYCLINE;

EID: 77949702437     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: 10.5897/ajb2010.000-3015     Document Type: Review
Times cited : (10)

References (77)
  • 1
    • 0035104891 scopus 로고    scopus 로고
    • Evolution of metronidazole and tetracycline susceptibility pattern in Helicobacter pylori at a hospital in Saudi Arabia
    • Abdul RA, Fikry E Abdul AA (2001). Evolution of metronidazole and tetracycline susceptibility pattern in Helicobacter pylori at a hospital in Saudi Arabia. Int. J. Antimicrob. Agents, 17(3): 233-236.
    • (2001) Int. J. Antimicrob. Agents , vol.17 , Issue.3 , pp. 233-236
    • Abdul, R.A.1    Fikry, E.2    Abdul, A.A.3
  • 2
    • 33644634911 scopus 로고    scopus 로고
    • Antimicrobial susceptibility of Helicobacter pylori isolates of dyspeptic Nigerian patients
    • Abdurasheed A, Lawal OO, Abioye-kuteyi EA, Lamikanra A (2005). Antimicrobial susceptibility of Helicobacter pylori isolates of dyspeptic Nigerian patients. J. Trop. Gastroenterol. 26: 85-88.
    • (2005) J. Trop. Gastroenterol , vol.26 , pp. 85-88
    • Abdurasheed, A.1    Lawal, O.O.2    Abioye-kuteyi, E.A.3    Lamikanra, A.4
  • 3
    • 33846899743 scopus 로고    scopus 로고
    • Update on Helicobacter pylori treatment
    • Ables AZ, Simon I, Melton ER (2007). Update on Helicobacter pylori treatment. Am. Fam. Physician, 75(3): 351-358.
    • (2007) Am. Fam. Physician , vol.75 , Issue.3 , pp. 351-358
    • Ables, A.Z.1    Simon, I.2    Melton, E.R.3
  • 5
    • 0032034028 scopus 로고    scopus 로고
    • Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole and amoxicillin influence on treatment outcome
    • Adamek RJ, Suerbaum S, Pfatenbach B, Operkuch S (1998). Primary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole and amoxicillin influence on treatment outcome. Am. J. Gastroenterol. 93: 386-389.
    • (1998) Am. J. Gastroenterol , vol.93 , pp. 386-389
    • Adamek, R.J.1    Suerbaum, S.2    Pfatenbach, B.3    Operkuch, S.4
  • 6
    • 0033012877 scopus 로고    scopus 로고
    • Antibiotic resistance problems with Helicobacter pylori: Review article
    • Alarcon T, Domingo D, López-Brea M (1999). Antibiotic resistance problems with Helicobacter pylori: Review article. Int. J. Antimicrob. Agents, 12: 19-26
    • (1999) Int. J. Antimicrob. Agents , vol.12 , pp. 19-26
    • Alarcon, T.1    Domingo, D.2    López-Brea, M.3
  • 7
    • 0035104891 scopus 로고    scopus 로고
    • Evolution of metronidazole and tetracycline susceptibility pattern in Helicobacter pylori at a hospital in Saudi Arabia
    • Al-Quarashi AR, El-Morsy F, Al-Quorain AA (2001). Evolution of metronidazole and tetracycline susceptibility pattern in Helicobacter pylori at a hospital in Saudi Arabia. Int. J. Antimicrob. Agents, 17: 233-236.
    • (2001) Int. J. Antimicrob. Agents , vol.17 , pp. 233-236
    • Al-Quarashi, A.R.1    El-Morsy, F.2    Al-Quorain, A.A.3
  • 8
    • 33750103840 scopus 로고    scopus 로고
    • Antimicrobial susceptibility pattern of Helicobacter pylori strains isolated from adult dyspeptic patients in Tikur Ambassa University Hospital Addis Ababa
    • Asrat D, Kassa E, Mengistu Y, Nilsson I, Wadstrom T (2004). Antimicrobial susceptibility pattern of Helicobacter pylori strains isolated from adult dyspeptic patients in Tikur Ambassa University Hospital Addis Ababa. Ethiop. Med. J. 42(2): 79-85.
    • (2004) Ethiop. Med. J , vol.42 , Issue.2 , pp. 79-85
    • Asrat, D.1    Kassa, E.2    Mengistu, Y.3    Nilsson, I.4    Wadstrom, T.5
  • 9
    • 0027948219 scopus 로고
    • High prevalence of Helicobacter pylori metronidazole resistance in migrants to East London: Relation with previous nitroimidazole exposure and gastroduodenal disease
    • Banatvala N, Davies GR, Abdi Y, Clements L, Rampton DS, Hardie JM, Feldman RA (1994). High prevalence of Helicobacter pylori metronidazole resistance in migrants to East London: relation with previous nitroimidazole exposure and gastroduodenal disease. Gut, 35: 1562-1566.
    • (1994) Gut , vol.35 , pp. 1562-1566
    • Banatvala, N.1    Davies, G.R.2    Abdi, Y.3    Clements, L.4    Rampton, D.S.5    Hardie, J.M.6    Feldman, R.A.7
  • 10
    • 0026669159 scopus 로고    scopus 로고
    • Bell GD, Powell K, Burridge SM, Pallecaros A, Jones PH, Gant PW et al (Provide Complete Name) (1992). Experience with 'triple' anti-Helicobacter pylori eradication therapy: side effects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance. Aliment Pharmnacol. Ther. 6: 427-435.
    • Bell GD, Powell K, Burridge SM, Pallecaros A, Jones PH, Gant PW et al (Provide Complete Name) (1992). Experience with 'triple' anti-Helicobacter pylori eradication therapy: side effects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance. Aliment Pharmnacol. Ther. 6: 427-435.
  • 12
    • 0026587458 scopus 로고
    • Proposed mechanism for metronidazole resistance in Helicobacter pylori
    • Cederbrant G, Kahlmeter G, Ljungh A (1992). Proposed mechanism for metronidazole resistance in Helicobacter pylori. J. Antimicrob. Chemother. 29: 115-120.
    • (1992) J. Antimicrob. Chemother , vol.29 , pp. 115-120
    • Cederbrant, G.1    Kahlmeter, G.2    Ljungh, A.3
  • 13
    • 0037300006 scopus 로고    scopus 로고
    • Chaudhuri S, Chowdhury A, Datta S, Mukhopadhyay AK, Chattopadhyay S, Saha DR et al. (Provide Complete Name) (2003). Anti- Helicobacter pylori therapy in India: differences in eradication efficiency associated with particular alleles of vacuolating cytotoxin (vacA) gene. J. Gastroenterol. Hepatol. 18: 190-195
    • Chaudhuri S, Chowdhury A, Datta S, Mukhopadhyay AK, Chattopadhyay S, Saha DR et al. (Provide Complete Name) (2003). Anti- Helicobacter pylori therapy in India: differences in eradication efficiency associated with particular alleles of vacuolating cytotoxin (vacA) gene. J. Gastroenterol. Hepatol. 18: 190-195
  • 14
    • 0029938341 scopus 로고    scopus 로고
    • Ching CK, Leung KP, Yung RW et al. (Provide Complete Name) (1996). Prevalence of metronidazole resistant Helicobacter pylori strains among chinese peptic ulcer disease patients and normal controls in Hong Kong. Gut, 38: 675-678.
    • Ching CK, Leung KP, Yung RW et al. (Provide Complete Name) (1996). Prevalence of metronidazole resistant Helicobacter pylori strains among chinese peptic ulcer disease patients and normal controls in Hong Kong. Gut, 38: 675-678.
  • 15
    • 0037397218 scopus 로고    scopus 로고
    • Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance
    • Chisholm SA, Owen RJ (2003). Mutations in Helicobacter pylori rdxA gene sequences may not contribute to metronidazole resistance. J. Antimicrob. Chemother. 51: 995-999.
    • (2003) J. Antimicrob. Chemother , vol.51 , pp. 995-999
    • Chisholm, S.A.1    Owen, R.J.2
  • 16
    • 1242329131 scopus 로고    scopus 로고
    • Frameshift mutations in frxA occur frequently and do not provide a reliable marker for metronidazole resistance in UK isolates of Helicobacter pylori
    • Chisholm SA, Owen RJ (2004). Frameshift mutations in frxA occur frequently and do not provide a reliable marker for metronidazole resistance in UK isolates of Helicobacter pylori. J. Med. Microbiol. 53: 135-140.
    • (2004) J. Med. Microbiol , vol.53 , pp. 135-140
    • Chisholm, S.A.1    Owen, R.J.2
  • 18
    • 77949682742 scopus 로고    scopus 로고
    • Performance standards for antimicrobial susceptibility testing
    • Clinical and Laboratory Standards Institute CLSI, supplement. Wayne, PA, USA
    • Clinical and Laboratory Standards Institute (CLSI) (2007). Performance standards for antimicrobial susceptibility testing; fifteenth information supplement. Wayne, PA, USA.
    • (2007) fifteenth information
  • 19
    • 0032705996 scopus 로고    scopus 로고
    • Insertion of mini- IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637
    • Debets-Ossenkopp YJ (1999). Insertion of mini- IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637. Antimicrob. Agents Chemother. 43: 2657-2662
    • (1999) Antimicrob. Agents Chemother , vol.43 , pp. 2657-2662
    • Debets-Ossenkopp, Y.J.1
  • 20
    • 0027522732 scopus 로고
    • Nitroimidazole drugs-action and resistance mechanisms I. Mechanisms of action
    • Edwards DI (1993). Nitroimidazole drugs-action and resistance mechanisms I. Mechanisms of action. J. Antimicrob. Chemother. 31: 9-20.
    • (1993) J. Antimicrob. Chemother , vol.31 , pp. 9-20
    • Edwards, D.I.1
  • 21
    • 0026488220 scopus 로고
    • European Multicenter Study Group on antibiotic susceptibility of Helicobacter pylori. Results of a mulicentre European survey in 1991 of metronidazole resistance in Helicobacter pylori
    • Glupczynski Y (1992). European Multicenter Study Group on antibiotic susceptibility of Helicobacter pylori. Results of a mulicentre European survey in 1991 of metronidazole resistance in Helicobacter pylori. Eur. J. Clin. Microbiol. Infect. Dis. 11: 777-781.
    • (1992) Eur. J. Clin. Microbiol. Infect. Dis , vol.11 , pp. 777-781
    • Glupczynski, Y.1
  • 22
    • 0029880401 scopus 로고    scopus 로고
    • Antimicrobial resistance and Helicobacter pylori
    • Goddard AF, Logan RP (1996). Antimicrobial resistance and Helicobacter pylori. J. Antimicrob. Chemother. 37: 639-643.
    • (1996) J. Antimicrob. Chemother , vol.37 , pp. 639-643
    • Goddard, A.F.1    Logan, R.P.2
  • 24
    • 0031953727 scopus 로고    scopus 로고
    • Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase
    • Goodwin AD, Kersulyte G, Sisson SJ, Veldhuyzen van Zanten D, Berg E, Hoffman PS (1998). Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase. Mol. Microbiol. 28: 383-393.
    • (1998) Mol. Microbiol , vol.28 , pp. 383-393
    • Goodwin, A.D.1    Kersulyte, G.2    Sisson, S.J.3    Veldhuyzen van Zanten, D.4    Berg, E.5    Hoffman, P.S.6
  • 25
    • 0025821296 scopus 로고
    • Effect of triple therapy (antibiotics plus bismuth) on duodenal ulcer healing. A randomized controlled trial
    • Graham DY, Lew GM, Evans DG, Evans DJ, Klein PD (1991). Effect of triple therapy (antibiotics plus bismuth) on duodenal ulcer healing. A randomized controlled trial. Ann. Int. Med. 115(4): 266-269.
    • (1991) Ann. Int. Med , vol.115 , Issue.4 , pp. 266-269
    • Graham, D.Y.1    Lew, G.M.2    Evans, D.G.3    Evans, D.J.4    Klein, P.D.5
  • 26
    • 0031732311 scopus 로고    scopus 로고
    • Antibiotic resistance in Helicobacter pylori: Implications for therapy
    • Graham DY (1998). Antibiotic resistance in Helicobacter pylori: implications for therapy. Gastroenterology, 115: 1272-1277.
    • (1998) Gastroenterology , vol.115 , pp. 1272-1277
    • Graham, D.Y.1
  • 27
    • 4644370074 scopus 로고    scopus 로고
    • Helicobacter pylori: Review and update
    • Hardin FJ, Wright RA (2002). Helicobacter pylori: review and update. Arch. Hosp. Physician. 38(5): 23-31.
    • (2002) Arch. Hosp. Physician , vol.38 , Issue.5 , pp. 23-31
    • Hardin, F.J.1    Wright, R.A.2
  • 28
    • 0032899088 scopus 로고    scopus 로고
    • Antibiotic resistance mechanisms of Helicobacter pylori
    • Hoffman PS (1999). Antibiotic resistance mechanisms of Helicobacter pylori. Can. J. Gastroenterol. 13: 243-249.
    • (1999) Can. J. Gastroenterol , vol.13 , pp. 243-249
    • Hoffman, P.S.1
  • 29
    • 0029741586 scopus 로고    scopus 로고
    • Metabolic activities of metronidazole-sensitive and - resistant strains of Helicobacter pylori: Repression of pyruvate oxidoreductase and expression of isocitrate lyase activity correlate with resistance
    • Hoffman PS, Goodwin A, Johnsen J, Magee K, Veldhuyzen van Zanten SJ (1996). Metabolic activities of metronidazole-sensitive and - resistant strains of Helicobacter pylori: repression of pyruvate oxidoreductase and expression of isocitrate lyase activity correlate with resistance. J. Bacteriol. 178: 4822-4829
    • (1996) J. Bacteriol , vol.178 , pp. 4822-4829
    • Hoffman, P.S.1    Goodwin, A.2    Johnsen, J.3    Magee, K.4    Veldhuyzen van Zanten, S.J.5
  • 30
    • 0033054099 scopus 로고    scopus 로고
    • The role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pylori
    • Jenks PJ, Ferrero RL, Labigne A (1999). The role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pylori. J. Antimicrob. Chemother. 43: 753-758.
    • (1999) J. Antimicrob. Chemother , vol.43 , pp. 753-758
    • Jenks, P.J.1    Ferrero, R.L.2    Labigne, A.3
  • 31
    • 0032891973 scopus 로고    scopus 로고
    • Exposure to metronidazole in vivo readily induces resistance in Helicobacter pylori and reduces the efficacy of eradication therapy in mice
    • Jenks PJ, Labigne A, Ferrero LR (1999). Exposure to metronidazole in vivo readily induces resistance in Helicobacter pylori and reduces the efficacy of eradication therapy in mice. Antimicrob. Agents Chemother. 43: 777-781.
    • (1999) Antimicrob. Agents Chemother , vol.43 , pp. 777-781
    • Jenks, P.J.1    Labigne, A.2    Ferrero, L.R.3
  • 32
    • 0033735156 scopus 로고    scopus 로고
    • Mouse-colonizing Helicobacter pylori SS1 is unusually susceptible to metronidazole due to two complementary reductase activities
    • Jeong JY, Berg DE (2000). Mouse-colonizing Helicobacter pylori SS1 is unusually susceptible to metronidazole due to two complementary reductase activities. Antimicrob. Agents Chemother. 44(11): 3127-3132
    • (2000) Antimicrob. Agents Chemother , vol.44 , Issue.11 , pp. 3127-3132
    • Jeong, J.Y.1    Berg, D.E.2
  • 33
    • 0033811410 scopus 로고    scopus 로고
    • Jeong JY, Mukhopadhyay AK, Dailidiene D, Wang Y, Velapatiño B, Gilman RH et al (Provide Complete Name) (2000). Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori. J. Bacteriol. 182(18): 5082-90.
    • Jeong JY, Mukhopadhyay AK, Dailidiene D, Wang Y, Velapatiño B, Gilman RH et al (Provide Complete Name) (2000). Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori. J. Bacteriol. 182(18): 5082-90.
  • 34
    • 0034879759 scopus 로고    scopus 로고
    • Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole
    • Jeong, JY, Mukhopadhyay AK, Akada JK, Dailidiene D, Hoffman P, Berg DE (2001). Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole. J. Bacteriol. 183: 5155-5162.
    • (2001) J. Bacteriol , vol.183 , pp. 5155-5162
    • Jeong, J.Y.1    Mukhopadhyay, A.K.2    Akada, J.K.3    Dailidiene, D.4    Hoffman, P.5    Berg, D.E.6
  • 35
    • 0035881218 scopus 로고    scopus 로고
    • Jorgensen MA et al (Provide Complete Name) (2001). Potential involvement of several nitroreductases in metronidazole resistance in Helicobacter pylori. Arch. Biochem. Biophys. 392: 180-191
    • Jorgensen MA et al (Provide Complete Name) (2001). Potential involvement of several nitroreductases in metronidazole resistance in Helicobacter pylori. Arch. Biochem. Biophys. 392: 180-191
  • 37
    • 0034955729 scopus 로고    scopus 로고
    • Antimicrobial susceptibilities of Helicobacter pylori isolates under microaerophilic atmospheres established by two different methods
    • Kobayashi I, Muraoka H, Saika T, Nishida M, Fujioka T, Nasu M (2001). Antimicrobial susceptibilities of Helicobacter pylori isolates under microaerophilic atmospheres established by two different methods. J. Clin. Microbiol. 39: 2646-2647.
    • (2001) J. Clin. Microbiol , vol.39 , pp. 2646-2647
    • Kobayashi, I.1    Muraoka, H.2    Saika, T.3    Nishida, M.4    Fujioka, T.5    Nasu, M.6
  • 38
    • 0033913344 scopus 로고    scopus 로고
    • Kwon DH, El-Zaatari FA, Kato M, Osato MS, Reddy R, Yamaoka Y et al (Provide Complete Name) (2000a). Analysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein (FdxB) in metronidazole resistance of Helicobacter pylori. Antimicrob Agents Chemother. 44(8): 2133-2142
    • Kwon DH, El-Zaatari FA, Kato M, Osato MS, Reddy R, Yamaoka Y et al (Provide Complete Name) (2000a). Analysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein (FdxB) in metronidazole resistance of Helicobacter pylori. Antimicrob Agents Chemother. 44(8): 2133-2142
  • 39
    • 0034662401 scopus 로고    scopus 로고
    • Frame-shift mutations in NAD(P)H flavin oxidoreductase encoding gene (frxA) from metronidazole resistant Helicobacter pylori ATCC43504 and its involvement in metronidazole resistance
    • Kwon DH, Kato M, El-Zaatari FA, Osato MS, Graham DY (2000b). Frame-shift mutations in NAD(P)H flavin oxidoreductase encoding gene (frxA) from metronidazole resistant Helicobacter pylori ATCC43504 and its involvement in metronidazole resistance. FEMS Microbiol. Lett. 188: 197-202
    • (2000) FEMS Microbiol. Lett , vol.188 , pp. 197-202
    • Kwon, D.H.1    Kato, M.2    El-Zaatari, F.A.3    Osato, M.S.4    Graham, D.Y.5
  • 40
    • 0034863519 scopus 로고    scopus 로고
    • Kwon DH, Hulten K, Kato M, Kim JJ, Lee M, El-Zaatari FA et al (Provide Complete Name) (2001). DNA sequence analysis of rdxA and frxA from 12 pairs of metronidazole-sensitive and -resistant clinical Helicobacter pylori isolates. Antimicrob Agents Chemother. 45: 2609-2615.
    • Kwon DH, Hulten K, Kato M, Kim JJ, Lee M, El-Zaatari FA et al (Provide Complete Name) (2001). DNA sequence analysis of rdxA and frxA from 12 pairs of metronidazole-sensitive and -resistant clinical Helicobacter pylori isolates. Antimicrob Agents Chemother. 45: 2609-2615.
  • 41
    • 0002079413 scopus 로고    scopus 로고
    • Randomized study comparing two seven days triple therapies with lansoprazole and low dose of clarithromycin plus amoxicillin or tinidazole for H. pylori eradication
    • Lamouliatte H, Talbi P, Cayla R, Zerbib F, Megraud F (1996). Randomized study comparing two seven days triple therapies with lansoprazole and low dose of clarithromycin plus amoxicillin or tinidazole for H. pylori eradication. Gut, 39(Suppl. 2): A35.
    • (1996) Gut , vol.39 , Issue.SUPPL. 2
    • Lamouliatte, H.1    Talbi, P.2    Cayla, R.3    Zerbib, F.4    Megraud, F.5
  • 42
    • 0041525487 scopus 로고    scopus 로고
    • Antibiotic resistance of Helicobacter pylori: A cross-sectional study in consecutive patients, and relations to ethnicity
    • Loffeld RJL, Fijen F, Camp MJ (2003). Antibiotic resistance of Helicobacter pylori: a cross-sectional study in consecutive patients, and relations to ethnicity. Clin. Microbiol. Infect. 9: 600-604.
    • (2003) Clin. Microbiol. Infect , vol.9 , pp. 600-604
    • Loffeld, R.J.L.1    Fijen, F.2    Camp, M.J.3
  • 43
    • 0041005224 scopus 로고    scopus 로고
    • Evolution of resistance to metronidazole and clarithromycin in Helicobacter pylori isolated from Spain
    • Lopez-Brea M, Domingo D, Sánchez I, Alarcón T (1997). Evolution of resistance to metronidazole and clarithromycin in Helicobacter pylori isolated from Spain. J. Antimicrob. Chemother. 40: 279-281.
    • (1997) J. Antimicrob. Chemother , vol.40 , pp. 279-281
    • Lopez-Brea, M.1    Domingo, D.2    Sánchez, I.3    Alarcón, T.4
  • 44
    • 33644591729 scopus 로고    scopus 로고
    • Drug susceptibility pattern of Helicobacter pylori in patients with dyspepsia at the Kenyatta National Hospital, Nairobi
    • Lwai-lume L, Ogutu EO, Amayo EO, Kariuki S (2005). Drug susceptibility pattern of Helicobacter pylori in patients with dyspepsia at the Kenyatta National Hospital, Nairobi. East Afr. Med. J. 82: 603-608.
    • (2005) East Afr. Med. J , vol.82 , pp. 603-608
    • Lwai-lume, L.1    Ogutu, E.O.2    Amayo, E.O.3    Kariuki, S.4
  • 46
    • 0037341768 scopus 로고    scopus 로고
    • Characterization of the genes rdxA and frxA involved in metronidazole resistance in Helicobacter pylori
    • Marais A, Bilardi C, Cantet F, Mendz GL, Megraud F (2003). Characterization of the genes rdxA and frxA involved in metronidazole resistance in Helicobacter pylori. Res. Microbiol. 154: 137-144.
    • (2003) Res. Microbiol , vol.154 , pp. 137-144
    • Marais, A.1    Bilardi, C.2    Cantet, F.3    Mendz, G.L.4    Megraud, F.5
  • 47
    • 0030903560 scopus 로고    scopus 로고
    • Resistance to Helicobacter pylori to antibiotics
    • Megraud F (1997). Resistance to Helicobacter pylori to antibiotics. Aliment Pharmacol. Ther. 11(Suppl 1): 43-53
    • (1997) Aliment Pharmacol. Ther , vol.11 , Issue.SUPPL. 1 , pp. 43-53
    • Megraud, F.1
  • 48
    • 0031846253 scopus 로고    scopus 로고
    • Clinical relevance of resistant strains of Helicobacter pylori: A review of current data
    • Megraud F, Doermann HP (1998). Clinical relevance of resistant strains of Helicobacter pylori: a review of current data. Gut, 43 (suppl 1): S61-S65
    • (1998) Gut , vol.43 , Issue.SUPPL. 1
    • Megraud, F.1    Doermann, H.P.2
  • 49
    • 4344592305 scopus 로고    scopus 로고
    • H pylori antibiotic resistance: Prevalence, importance, and advances in testing
    • Megraud F (2004). H pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut, 53(9): 1374-1384.
    • (2004) Gut , vol.53 , Issue.9 , pp. 1374-1384
    • Megraud, F.1
  • 50
    • 34248145588 scopus 로고    scopus 로고
    • Helicobacter pylori detection and antimicrobial susceptibility testing
    • Megraud F, Lehours P (2007). Helicobacter pylori detection and antimicrobial susceptibility testing. Clin. Microbiol. Rev. 20: 280-322.
    • (2007) Clin. Microbiol. Rev , vol.20 , pp. 280-322
    • Megraud, F.1    Lehours, P.2
  • 51
    • 0036685430 scopus 로고    scopus 로고
    • Is the molecular basis of metronidazole resistance in microaerophilic organisms understood?
    • Mendz GL, Mégraud F (2002). Is the molecular basis of metronidazole resistance in microaerophilic organisms understood? Trends Microbiol. 10: p. 370.
    • (2002) Trends Microbiol , vol.10 , pp. 370
    • Mendz, G.L.1    Mégraud, F.2
  • 52
    • 0036534963 scopus 로고    scopus 로고
    • Management of Helicobacter pylori Infection
    • Meurer L, Bower D (2002). Management of Helicobacter pylori Infection. Am. Fam. Physician, 65(7): 1327-1339.
    • (2002) Am. Fam. Physician , vol.65 , Issue.7 , pp. 1327-1339
    • Meurer, L.1    Bower, D.2
  • 53
    • 4644265885 scopus 로고    scopus 로고
    • Helicobacter pylori antigens in the faeces of asymptomatic children in the Buea and Limbe health districts of Cameroon: A pilot study
    • Ndip RN, Malange AE, Akoachere JFT, MacKay WG, Titanji VPK, Weaver LT (2004). Helicobacter pylori antigens in the faeces of asymptomatic children in the Buea and Limbe health districts of Cameroon: a pilot study. Trop. Med. Int. Health, 9(9): 1036-1040.
    • (2004) Trop. Med. Int. Health , vol.9 , Issue.9 , pp. 1036-1040
    • Ndip, R.N.1    Malange, A.E.2    Akoachere, J.F.T.3    MacKay, W.G.4    Titanji, V.P.K.5    Weaver, L.T.6
  • 54
    • 58649083515 scopus 로고    scopus 로고
    • Ndip R, Malange Takang AE, Echakachi CE, Malongue A, Akoachere J-FTK, Ndip LM et al (Provide Complete Name) (2007a). In vitro antimicrobial activity of selected honeys on clinical isolates of Helicobacter pylori. Afr. Health Sci. 7(4): 228-231.
    • Ndip R, Malange Takang AE, Echakachi CE, Malongue A, Akoachere J-FTK, Ndip LM et al (Provide Complete Name) (2007a). In vitro antimicrobial activity of selected honeys on clinical isolates of Helicobacter pylori. Afr. Health Sci. 7(4): 228-231.
  • 58
    • 0033774876 scopus 로고    scopus 로고
    • Antimicrobial susceptibility testing for Helicobacter pylori: Sensitivity test results and their clinical relevance
    • Osato MS (2000). Antimicrobial susceptibility testing for Helicobacter pylori: sensitivity test results and their clinical relevance. Curr. Pharm. Des. 6: 1545-1555.
    • (2000) Curr. Pharm. Des , vol.6 , pp. 1545-1555
    • Osato, M.S.1
  • 59
    • 0033179196 scopus 로고    scopus 로고
    • Metronidazole and clarithromycin resistance amongst Helicobacter pylori isolates from a large metropolitan hospital in the United States
    • Osato MS, Reddy R, Graham DY (1999). Metronidazole and clarithromycin resistance amongst Helicobacter pylori isolates from a large metropolitan hospital in the United States. Int. J. Antimicrob. Agents, 12(4): 341-347.
    • (1999) Int. J. Antimicrob. Agents , vol.12 , Issue.4 , pp. 341-347
    • Osato, M.S.1    Reddy, R.2    Graham, D.Y.3
  • 60
    • 0035111966 scopus 로고    scopus 로고
    • Mutations of the Helicobacter pylori genes rdxA and pbp1 cause resistance against metronidazole and amoxicillin
    • Paul R, Postius S, Melchers K, Schäfer KP (2001). Mutations of the Helicobacter pylori genes rdxA and pbp1 cause resistance against metronidazole and amoxicillin. Antimicrob. Agents Chemother. 45: 962-965.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 962-965
    • Paul, R.1    Postius, S.2    Melchers, K.3    Schäfer, K.P.4
  • 61
    • 0032571821 scopus 로고    scopus 로고
    • Treatment of Helicobacter pylori infection
    • Salcedo JA, Al-Kawas F (1998). Treatment of Helicobacter pylori infection. Arch. Int. Med. 158: 842-851.
    • (1998) Arch. Int. Med , vol.158 , pp. 842-851
    • Salcedo, J.A.1    Al-Kawas, F.2
  • 62
    • 0036033701 scopus 로고    scopus 로고
    • Helicobacter pylori and gastric malignancies
    • Sepulvedo AR, Coelho LGV (2002). Helicobacter pylori and gastric malignancies. Helicobacter. 7: 37-42
    • (2002) Helicobacter , vol.7 , pp. 37-42
    • Sepulvedo, A.R.1    Coelho, L.G.V.2
  • 63
    • 5444241865 scopus 로고    scopus 로고
    • Universal high-level primary metronidazole resistance in Helicobacter pylori isolated from children in Egypt
    • Sherif M, Zaynab M, Hanan F, Rockabrand DM, Rozmajzl PJ, Frenck RW (2004). Universal high-level primary metronidazole resistance in Helicobacter pylori isolated from children in Egypt. J. Clin. Microbiol. 42: 4832-4834.
    • (2004) J. Clin. Microbiol , vol.42 , pp. 4832-4834
    • Sherif, M.1    Zaynab, M.2    Hanan, F.3    Rockabrand, D.M.4    Rozmajzl, P.J.5    Frenck, R.W.6
  • 64
    • 0033928525 scopus 로고    scopus 로고
    • Mechanism of metronidazole resistance in Helicobacter pylori: Comparison of the rdxA gene sequences of 30 strains
    • Solca MM, Bernasconi MV, Piffarethi JC (2000). Mechanism of metronidazole resistance in Helicobacter pylori: comparison of the rdxA gene sequences of 30 strains. Antimicrob. Agents Chemother. 44: 2207-2210.
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 2207-2210
    • Solca, M.M.1    Bernasconi, M.V.2    Piffarethi, J.C.3
  • 65
    • 0035126019 scopus 로고    scopus 로고
    • High amoxicillin resistance in Helicobacter pylori from gastritis and peptic ulcer patients in western Nigeria
    • Smith SI, Oyedeji KS, Arigbabu,AO, Atimomo C, Coker AO (2001). High amoxicillin resistance in Helicobacter pylori from gastritis and peptic ulcer patients in western Nigeria. J. Gastroenterol. 36: 67-68.
    • (2001) J. Gastroenterol , vol.36 , pp. 67-68
    • Smith, S.I.1    Oyedeji, K.S.2    Arigbabu, A.O.3    Atimomo, C.4    Coker, A.O.5
  • 66
    • 0037057683 scopus 로고    scopus 로고
    • Helicobacter pylori infection
    • Suerbaum S, Michetti P (2002). Helicobacter pylori infection. N. Engl. J. Med. 347: 1175-1186.
    • (2002) N. Engl. J. Med , vol.347 , pp. 1175-1186
    • Suerbaum, S.1    Michetti, P.2
  • 67
    • 65249125113 scopus 로고    scopus 로고
    • An African perspective on Helicobacter pylori: Prevalence of human infection, drug resistance, and alternative approaches to treatment
    • Tanih NF, Dube C, Green E, Mkwetshana N, Clarke AM, Ndip LM, Ndip RN (2009). An African perspective on Helicobacter pylori: prevalence of human infection, drug resistance, and alternative approaches to treatment. Ann. Trop. Med. Parasitol. 103: 189-204.
    • (2009) Ann. Trop. Med. Parasitol , vol.103 , pp. 189-204
    • Tanih, N.F.1    Dube, C.2    Green, E.3    Mkwetshana, N.4    Clarke, A.M.5    Ndip, L.M.6    Ndip, R.N.7
  • 68
    • 75649151202 scopus 로고    scopus 로고
    • Tanih NF, Okeleye BI, Naido N, Clarke AM, Mkweshana N, Green E, Ndip LM, Ndip RN (2010). Marked susceptibility of South African Helicobacter pylori strains to ciprofloxacin and amoxicillin: Clinical implication. S. Afr. Med. J. 100 (1): 49-52.
    • Tanih NF, Okeleye BI, Naido N, Clarke AM, Mkweshana N, Green E, Ndip LM, Ndip RN (2010). Marked susceptibility of South African Helicobacter pylori strains to ciprofloxacin and amoxicillin: Clinical implication. S. Afr. Med. J. 100 (1): 49-52.
  • 69
    • 0034000527 scopus 로고    scopus 로고
    • Frequent association between alteration of the rdxA gene and metronidazole resistance in French and North African isolates of Helicobacter pylori
    • Tankovic JD, Lamarque JC, Delchier CJ, Soussy A, Labigne C, Jenks PJ (2000). Frequent association between alteration of the rdxA gene and metronidazole resistance in French and North African isolates of Helicobacter pylori. Antimicrob. Agents Chemother. 44: 608-613.
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 608-613
    • Tankovic, J.D.1    Lamarque, J.C.2    Delchier, C.J.3    Soussy, A.4    Labigne, C.5    Jenks, P.J.6
  • 70
    • 0345256311 scopus 로고    scopus 로고
    • Relationship of plasmid profile with the antibiotic sensitivity pattern of Helicobacter pylori isolates from peptic ulcer disease patients in Chennai
    • Thyagarajan SP, Dharmalingam S, Rao UA, Jayaraman G (2003). Relationship of plasmid profile with the antibiotic sensitivity pattern of Helicobacter pylori isolates from peptic ulcer disease patients in Chennai. Indian J. Med. Microbiol. 21(4): 257-261.
    • (2003) Indian J. Med. Microbiol , vol.21 , Issue.4 , pp. 257-261
    • Thyagarajan, S.P.1    Dharmalingam, S.2    Rao, U.A.3    Jayaraman, G.4
  • 74
    • 9244264392 scopus 로고    scopus 로고
    • Metronidazole and clarithromycin resistance in Helicobacter pylori determined by measuring MICs of antimicrobial agents in color indicator egg yolk agar in a miniwell format
    • Vasques A, Valdez Y, Gilman RH, McDonald JJ, Westblom TU, Berg D, Mayta H, Gutierrez V (1996). Metronidazole and clarithromycin resistance in Helicobacter pylori determined by measuring MICs of antimicrobial agents in color indicator egg yolk agar in a miniwell format. J. Clin. Microbiol. 34: 1232-1234.
    • (1996) J. Clin. Microbiol , vol.34 , pp. 1232-1234
    • Vasques, A.1    Valdez, Y.2    Gilman, R.H.3    McDonald, J.J.4    Westblom, T.U.5    Berg, D.6    Mayta, H.7    Gutierrez, V.8
  • 75
    • 0002862031 scopus 로고    scopus 로고
    • Adding once-daily omeprazole 20mg to metronidazole/amoxycillin treatment for Helicobacter pylori gastritis: A randomized, doubleblind trial showing the importance of metronidazole resistance
    • Veldhuyzen van Zanten S, Hunt RH, Cockeram A, Schep G, Malatjalian D, Sidorov J, Matisko A, Jellell D (1998). Adding once-daily omeprazole 20mg to metronidazole/amoxycillin treatment for Helicobacter pylori gastritis: A randomized, doubleblind trial showing the importance of metronidazole resistance. Am. J. Gastroenterol. 93: 5-10.
    • (1998) Am. J. Gastroenterol , vol.93 , pp. 5-10
    • Veldhuyzen van Zanten, S.1    Hunt, R.H.2    Cockeram, A.3    Schep, G.4    Malatjalian, D.5    Sidorov, J.6    Matisko, A.7    Jellell, D.8


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