An African perspective on Helicobacter pylori: Prevalenc of human infection, drug resistance, and alternative approaches to treatment

Annals of Tropical Medicine and Parasitology

Volumn 103, Issue 3, 2009, Pages 189-204

  Tanih, N F ^a   Dube, C ^a   Green, E ^a   Mkwetshana, N ^a   Clarke, A M ^a   Ndip, L M ^b   Ndip, R N ^a,b  

^a Faculty of Science and Agriculture   (South Africa)

^b UNIVERSITY OF BUEA   (Cameroon)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDRO 8 HYDROXY PALMATINE; ACANTHUS MONTANUS EXTRACT; AGERATUM CONYZOIDES EXTRACT; AMOXICILLIN; AMPICILLIN; BISMUTH SALICYLATE; CIPROFLOXACIN; CLARITHROMYCIN; EMILIA COCCINEA EXTRACT; ENTADA ABYSSINICA EXTRACT; ERYNGIUM FOETIDIUM EXTRACT; EUPHORBIA EXTRACT; HERBACEOUS AGENT; HONEY EXTRACT; LEVOFLOXACIN; LYCOPODIUM CERNUA EXTRACT; METRONIDAZOLE; PLANT EXTRACT; PROTOBERBERINE DERIVATIVE; PROTON PUMP INHIBITOR; RABEPRAZOLE; RANITIDINE BISMUTH CITRATE; SCLERIA STRIATINUX EXTRACT; SCLERIA VERRUCOSA EXTRACT; TABERSONINE; TAPEINACHILUS ANANASSAE EXTRACT; TERMINALIA SPINOSA EXTRACT; TETRACYCLINE; TINIDAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFECTIVE AGENT;

ACANTHUS MONTANUS; AFRICA; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ANTIGEN DETECTION; AULATANDRA KAMERUNENSIS; AULATANDRA KAMERUNENSIS EXTRACT; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BACTERIUM CULTURE; BACTERIUM DETECTION; BACTERIUM ISOLATE; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; DRUG RESEARCH; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; DYSPEPSIA; EMILIA COCCINEA; ENTADA ABYSSINICA; ENZYME LINKED IMMUNOSORBENT ASSAY; ERADICATION THERAPY; ERYNGIUM; EUPHORBIA; FECES ANALYSIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HIGH RISK POPULATION; HONEY; HUMAN; LATEX AGGLUTINATION TEST; LYCOPODIUM; MEDICINAL PLANT; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; NONHUMAN; PATIENT COMPLIANCE; PEPTIC ULCER; PLANT STEM; POLYMERASE CHAIN REACTION; PREVALENCE; RACE DIFFERENCE; REVIEW; SCLERIA STRIATINUX; SCLERIA VERRUCOSA; SEROPREVALENCE; SHORT COURSE THERAPY; TAPEINACHILUS ANANASSAE; TERMINALIA; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT OUTCOME; TREATMENT RESPONSE; UREA BREATH TEST; VOACANGA; APITHERAPY; DRUG EFFECTS; HELICOBACTER INFECTIONS; PROCEDURES;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI; NEGIBACTERIA;

AFRICA; ANTI-BACTERIAL AGENTS; APITHERAPY; DRUG RESISTANCE, BACTERIAL; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HONEY; HUMANS; PLANTS, MEDICINAL; PROTON PUMP INHIBITORS;

EID: 65249125113     PISSN: 00034983     EISSN: None     Source Type: Journal    
DOI: 10.1179/136485909X398311     Document Type: Review

References (138)

1. Abdurasheed, A., Lawal, O. O., Abioye-kuteyi, E. A. & Lamikanra, A. (2005). Antimicrobial susceptibility of Helicobacter pylori isolates of dyspeptic Nigerian patients. Journal of Tropical Gastroenterology, 26, 85-88.
2. Ables, A. Z., Simon, I. & Melton, E. R. (2007). Update on Helicobacter pylori treatment. American Family Physician, 75, 351-358.
3. Aboderin, O. A., Abdu, A. R., Odetoyin, B. W., Okeke, I. N., Lawal, O. O., Ndububa, D. A., Agbakwuru, A. E. & Lamikanra, A. (2007). Antibiotic resistance of Helicobacter pylori from patients in Ile-Ife, south-west Nigeria. African Health Sciences, 3, 143-147.
4. Afolayan, A. J. (2003). Extracts from the shoots of Arctotis artotoides inhibit the growth of bacteria and fungi. Pharmaceutical Biology, 41, 22-25.
5. Aguemon, B. D., Struelens, M. J., Masougbodji, A. & Ouendo, E. M. (2005). Prevalence and risk factors for Helicobacter pylori infection in urban and rural Beninese population. Clinical Microbiology and Infection, 11, 611-617.
6. Ahmed, K., Farzana, R., Walter, M., Godfrey, L. & Martin, H. (2007). Histopathological profile of gastritis in adult patients seen at a referral hospital in Kenya. World Journal of Gastroenterology, 14, 4117-4121.
7. Akamatsu, T., Tabata, K., Hironga, M., Kawakami, H. & Uyeda, M. (1996). Transmission of Helicobacter pylori infection via flexible fiberoptic endoscopy. American Journal of Infection Control, 24, 396-401.
8. Akinyemi, K. O., Oladapo, O., Okwara, C. E., Ibe, C. C. & Fasure, K. A. (2005). Screening of crude extracts of six medicinal plants used in south-west Nigerian unorthodox medicine for anti-methicillin resistant Staphylococcus aureus activity. BMC Complementary and Alternative Medicine, 5, 6-13.
9. Al-Quarashi, A. R., El-Morsy, F. & Al-Quorain, A. A. (2001). Evolution of metronidazole and tetracycline susceptibility pattern in Helicobacter pylori at a hospital in Saudi Arabia. International Journal of Antimicrobial Agents, 17, 233-236.
10. Alarcón, T., Domingo, D. & López-Brea, M. (1999). Antibiotic resistance problems with Helicobacter pylori. International Journal of Antimicrobial Agents, 12, 19-26.
11. Anesini, C. & Perez, C. (1993). Screening of plants used in Argentine folk medicine for antimicrobial activity. Journal of Ethnopharmacology, 39, 119-128.
12. Anon. (1994). Schistosomes, Liver Flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. IRAC Monographs on the Evaluation of Carcinogenic Risks to Humans, 61, 1-241.
13. Asrat, D., Kassa, E., Mengistu, Y., Nilsson, I. & Wadström, T. (2004). Antimicrobial susceptibility pattern of Helicobacter pylori strains isolated from adult dyspeptic patients in Tikur Anbassa University Hospital, Addis Ababa, Ethiopia. Ethiopian Medical Journal, 42, 79-85.
14. Baako, B. N. & Darko, R. (1996). Incidence of Helicobacter pylori infection in Ghanian patients with dyspeptic symptoms referred for upper gastrointestinal endoscopy. West African Journal of Medicine, 15, 223-227.
15. Banatvala, N., Davies, G. R. & Abdi, Y. (1994). High prevalence of metronidazole resistance in migrants in East London: relation with previous nitroimidazole exposure and gastroduodenal disease. Gut, 35, 1562-1566.
16. Basualdo, C., Sgroy, V., Finda, M. S. & Marioli, J. M. (2007). Comparison of the antibacterial activity of honey from different provenance against bacteria usually isolated from skin wounds. Veterinary Microbiology, 124, 375-381
17. Ben-Ammar, A., Cheikh, I., Kchaou, M., Chouaib, S., Ouerghi, H. & Chaâbouni, H. (2003). Prevalence of Helicobacter pylori infection in normal or asymptomatic patients. Tunisie Médicale, 81, 200-204.
18. Boda, M., Paul, V. T. & Barthelemy, N. (2006). Rapid in vivo screening method for the evaluation of new anti-Helicobacter medicinal preparations. African Journal of Traditional, Complementary and Alternative Medicines, 3, 102-114.
19. Bytzer, P. & O'Morain, C. (2005). Treatment of Helicobacter pylori. Helicobacter, 10, 40-46.
20. Cherie, T. N., Gilchrist, C. A. Lane, A., Roy, S., Haque, R. & Houpt, E. R. (2005). Multiplex realtime PCR assay using scorpion probes and DNA capture for genotype-specific detection of Giardia lamblia in fecal samples. Journal of Clinical Microbiology, 43, 1256-1260.
21. Chisholm, S. A., Watson, C. L., Teare, E. L., Saverymuttu, S. & Owen, R. J. (2004). Non-invasive diagnosis of Helicobacter pylori infection in adult dyspeptic patients by stool antigen detection: does the rapid immunochromatography test provide a reliable alternative to conventional ELISA kits? Journal of Medical Microbiology, 53, 623-627.
22. Cotton, M. C. (1996). Ethnobotany, Principles and Applications. New York, NY: Wiley & Sons.
23. Cushnie, T. P. T. & Lamb, J. A. (2005). Antimicrobal activity of flavonoids. International Journal of Antimicrobial Agents, 26, 343-356.
24. Davis, C. (2005). The Use of Australian Honey in Moist Wound Management. Publication No. W05/159. Kingston, Australia: Rural Industries Research and Development Corporation.
25. Debets-Ossenkopp, Y. J., Pot, R. G. J. & van Westerloo, D. J. (1999). Insertion of mini-IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC 11637. Antimicrobial Agents and Chemotherapy, 43, 2657-2662.
26. Deloney, C. R. & Schiller, N. L. (2000). Characterization of an in-vitro selected amoxicillinresistant strain of Helicobacter pylori. Antimicrobial Agents and Chemotherapy, 44, 3363-3373.
27. Desta, B. (1993). Ethiopian traditional herbal drugs. Part II. Antimicrobial activity of 63 medicinal plants. Journal of Ethnopharmacology, 39, 129-139.
28. Diouf, A., Martinez-Gomis, J., Miquel, M., Quesada, M., Lario, S. & Sixou, M. (2009). Comparison of four different primer sets for detection of Helicobacter pylori in gastric biopsies and oral samples by using real-time PCR. Pathologie-biologie, in press.
29. Dixon, M. F. (1991). Helicobacter pylori and peptic ulceration. Histopathological aspects. Journal of Gastroenterology and Hepatology, 6, 125-130.
30. Dubois, A., Flala, N., Heman-Ackah, L. M., Drazek, E. S., Tarnawski, A., Fishbein, W. N., Perez-Perez, G. I. & Blaser, M. J. (1994). Natural gastric infection with Helicobacter pylori in monkeys; a model for spiral bacteria infection in humans. Gastroenterology, 106, 1405-1417.
31. Espy, M. J., Uhl, J. R., Sloan, L. M., Buckwalter, S. P., Jones, M. F., Vetter, E. A., Yao, J. D. C., Wengenack, N. L., Rosenblatt, J. E., Cockerill III, F. R. & Smith, T. F. (2006). Real-time PCR in clinical microbiology: applications for routine laboratory testing. Clinical Microbiology Reviews, 19, 65-256.
32. Fabry, W., Okemo, P. & Ansorg, R. (1996a). Activity of East African medicinal plants against Helicobacter pylori. Chemotherapy, 42, 315-317.
33. Fabry, W., Okemo, P., Mwatha, W. E., Chhabra,S.C.& Ansorg, R. (1996b). Susceptibility of Helicobacter pylori and Candida spp. to the East African plant Terminalia spinosa. Arzneimittel Forschung, 46, 539-540.
34. Farnsworth, N. R. (1994). Ethnopharmacology and drug development. In Ethnobotany and the Search for New Drugs, Ciba Foundation Symposium 185, pp. 42-59. Chichester, U.K.: John Wiley & Sons.
35. Farnsworth, N. R., Akerele, O. & Bingel, A. S. (1985). Medicinal plants in therapy. Bulletin of the World Health Organization, 63, 965-981.
36. Fennel, C. W., Lindsey, K. L., McGaw, L. J., Sparg, S. G., Stafford, G. I., Elorashi, E. E., Grace, O. M. & van Staden, J. (2004). Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology. Journal of Ethnopharmacology, 94, 205-217.
37. Fox, J. G., Batchelder, M., Marini, R., Yan, L., Handt, L., Li, X., Shamen, B., Hayward, A., Campbell, J. & Murphy, J. C. (1995). Helicobacter pylori-induced gastritis in the domestic cat. Infection and Immunity, 63, 2674-2681.
38. Fyhrquist, P., Mwasumbi, L., Haeggström, C. A., Vuorela, H., Hiltunen, R. & Vuorela, P. (2002). Ethnobotanical and antimicrobial investigation on some species of Terminalia and Combretum (Combretaceace) growing in Tanzania. Journal of Ethnopharmacology, 79, 169-177.
39. Gatta, L., Ricci, C., Tampieri, A. & Vaira, D. (2003). Non-invasive techniques for diagnosis of Helicobacter pylori infection. Journal of Clinical Microbiology and Infection, 9, 489-496.
40. George, N. M. & Cutting, K. F. (2007). Antibacterial honey (MedihoneyJ): in-vitro activity against clinical isolates of MRSA, VRE and other multiresistant Gram-negative organisms, including Pseudomonas aeruginosa. Wounds, 19, 231-236.
41. Gerrits, M. M., de Zoete, M. R., Arents, N. L. A., Kuipers, E. J. & Kusters, J. G. (2002). 16S rRNA mutation-mediated tetracycline resistance in Helicobacter pylori. Antimicrobial Agents and Chemotherapy, 46, 2996-3000.
42. Glocker, E., Berning, M., Gerrits, M. M., Kusters, J. G. & Kist, M. (2005). Real-time PCR screening for 16S rRNA mutations associated with resistance to tetracycline in Helicobacter pylori. Antimicrobial Agents and Chemotherapy, 49, 3166-3170.
43. Glocker, E., Stueger, H.-P. & Kist, M. (2007). Quinolone resistance in Helicobacter pylori isolates in Germany. Antimicrobial Agents and Chemotherapy, 51, 346-349
44. Govaerts, R. (2001). How many species of seed plants are there? Taxonomy, 50, 1085-1090.
45. Hardin, F. J. & Wright, R. A. (2002). Helicobacter pylori: review and update. Hospital Physician, 38, 23-31.
46. Henriksen, T. H., Nysaeter, G., Madebo, T., Seteqn, D., Brorson, O., Kebede, T. & Bersted, A. (1999). Peptic ulcer disease in South Ethiopia is strongly associated with Helicobacter pylori. Transactions of the Royal Society of Tropical Medicine and Hygiene, 93, 171-173.
47. Holcombe, C. (1992). Helicobacter pylori: the Africa enigma. Gut, 33, 429-431.
48. Iwu, M. W., Duncan, A. R. & Okunji, C. O. (1999). New antimicrobials of plant origin. In Perspectives on New Crops and New Uses, ed. Janick, J. pp. 457-462. Alexandria, VA: American Society for Horticultural Science Press.
49. Jäger, A. K., Hutchings, A. & van Staden, J. (1996). Screening of Zulu medicinal plants for prostaglandinsynthesis inhibitors. Journal of Ethnopharmacology, 52, 95-100.
50. Jeong, J.-Y, Mukhopadhyay, A. K., Akada, J. K., Dailidiene, D., Hoffman, P. S. & Berg, D. E. (2001). Roles of frxA and rdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole. Journal of Bacteriology, 183, 5155-5162.
51. Kalach, N., Bergeret, M., Benhamou, P. H., Dupont, C. & Josette, R. (2001). High levels of resistance to metronidazole and clarithromycin in Helicobacter pylori strains in children. Journal of Clinical Microbiology, 39, 394-397.
52. Kato, S., Fujimura, S., Udagawa, H., Shimizu, T., Mascara, S., Ozawa, K. & Limuma, K. (2002). Antibiotic resistance of Helicobacter pylori strains in Japanese children. Journal of Clinical Microbiology, 40, 649-653.
53. Kawakami, Y., Oana, K., Hayama, M., Ota, H., Takeuchi, M., Miyashita, K., Matsuzawa, T. & Kanaya, K. (2006). In vitro bactericidal activities of Japanese rice-fluid against Helicobacter pylori strains. International Journal of Medical Sciences, 3, 112-116.
54. Kersulyte, D., Chalkauskas, H. & Berg, D. E. (1999). Emergence of recombinant strains of Helicobacter pylori during human infection. Molecular Microbiology, 31, 31-43.
55. Kim, J. J., Reddy, R., Lee, M., Kim, J. G., El Satiric, F. A., Osato, M. S., Graham, D. Y. & Kwon, D. H. (2001). Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea. Journal of Antimicrobial Agents and Chemotherapy, 47, 459-461.
56. Klein, P. D., Graham, D. Y., Gaillour, A., Opekun, A. R. & Smith, E. O. (1991). Water source as risk factor for Helicobacter pylori infection in Peruvian children. Lancet, 337, 1503-1506.
57. Knigge, K. L. (2001). The role of Helicobacter pylori in gastrointestinal disease. A guide to identification and eradication. Journal of Postgraduate Medicine, 110, 71-82.
58. Kobayashi, I., Muraoka, H., Saika, T., Nishida, M., Fujioka, T. & Nasu, M. (2001). Antimicrobial susceptibilities of Helicobacter pylori isolates under microaerophilic atmospheres established by two different methods. Journal of Clinical Microbiology, 39, 2646-2647.
59. Kori, M., Goldstein, E. & Granot, E. (2009). Helicobacter pylori infection in young children detected by a monoclonal stool antigen immunoassay. Pediatric Infectious Diseases Journal, 28, 157-159.
60. Krausse, R., Müller, G. & Doniec, M. (2008). Evaluation of a rapid new stool antigen test for diagnosis of Helicobacter pylori infection in adult patients. Journal of Clinical Microbiology, 46, 2062-2065.
61. Krogfelt, K. A., Lehours, P. & Mégraud, F. (2005). Diagnosis of Helicobacter pylori infection. Helicobacter, 10, 5-13.
62. Kwon, D. H., Hulten, K., Kato, M., Kim, J. J., Lee, M., El-Zaatari, F. A. K., Osato, M. S. & Graham, D. Y. (2001). DNA sequence analysis of rdxA and frxA from 12 pairs of metronidazole-sensitive and -resistant clinical Helicobacter pylori isolates. Antimicrobial Agents and Chemotherapy, 45, 2609-2615.
63. Langat, A. C., Ogutu, E., Kamenwa, R. & Simiyu, D. E. (2006). Prevalence of Helicobacter pylori in children less than three years of age in health facilities in Nairobi province. East African Medical Journal, 83, 471-477.
64. Lay-flurrie, K. (2008). Honey in wound care: effects, clinical application and patient benefit. British Journal of Nursing, 17 (Suppl.), S30-S36.
65. Lesbros-Pantoflickova, D., Corthésy-Theulaz, I. & Blum, L. A. (2007). Helicobacter pylori and probiotics. Journal of Nutrition, 137, 812S-818S.
66. Liu, C. X. (1978). Development of Chinese medicine based on pharmacology and therapeutics. Journal of Ethnopharmacology, 19, 119-123.
67. Loffeld, R. J. L. F. & Fijen, C. A. P. M. J. (2003). Antibiotic resistance of Helicobacter pylori: a cross-sectional study in consecutive patients, and relations to ethnicity. Clinical Microbiology and Infection, 9, 600-604.
68. Logan, R. P. H. and Walker, M. M. (2001). Epidemiology and diagnosis of Helicobacter pylori infection. British Medical Journal, 323, 920-922.
69. Longo-Mbenza, B., Nsenga, J. N. & Ngoma, V. D. (2007). Prevention of metabolic syndrome insulin resistance and atherosclerotic in diseases in Africans infected by Helicobacter pylori infection and treated with antibiotics. International Journal of Cardiology, 121, 229-238.
70. Lwai-Lume, L., Ogutu, E. O., Amayo, E. O. & Kariuki, S. (2005). Drug susceptibility pattern of Helicobacter pylori in patients with dyspepsia at the Kenyatta National Hospital, Nairobi. East African Medical Journal, 82, 603-608.
71. MacKay, W. G., Williams, C. L., McMillan, M., Ndip, R. N., Shepherd, A. J. & Weaver, L. T. (2003). Evaluation of protocol using gene capture and PCR for detection of Helicobacter pylori DNA in feces. Journal of Clinical Microbiology, 41, 4589-4592.
72. Maherzi, A., Bouaziz, A. A., Fendric, C., Oubich, F., Koubaa, C., Fauchere, J. L. & Brusnina, S. (2003). Helicobacter pylori infection: prospective study for asymptomatic Tunisian children. Archives of Pediatrics, 10, 204-207.
73. Marshall, B. J., Goodwin, C. S., Warren, J. R., Murray, R., Blincow, E. D., Blackboum, S. J., Philips, M., Walters, T. E. & Sanderson, C. R. (1988). Prospective double blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet, ii, 1437-1442.
74. Marshall, M. J. & Warren, R. J. (1983). Unidentified curved bacilli on gastric epithelium active chronic gastritis. Lancet, i, 1273-1275.
75. Mbengue, M., Diouf, M. L., Dangou, J. M., Ka, M. M., Ba-Seck, A., Ndiaye, M. F., Moreire-Diop, T. & Ndiaye, P. D. (1997). Frequency of Helicobacter pylori infection in symptomatic patients in Senegal. Médecine Tropicale, 57, 256-258.
76. Mégraud, F. (1995). Transmission of Helicobacter pylori: faecal-oral versus oral-oral route. Alimentary Pharmacology and Therapeutics, 9, 85-91.
77. Mégraud, F. (1997). How should Helicobacter pylori be diagnosed? Gastroenterology, 133, S93-S98.
78. Mégraud, F. (1998). Epidemiology and mechanism of antibiotic resistance in Helicobacter pylori. Gastroenterology, 115, 1278-1282.
79. Mégraud, F. (2004). Helicobacter pylori antibiotic resistance: prevalence, importance and advances in testing. Gut, 53, 1374-1384.
80. Mégraud, F. & Lehours, P. (2007). Helicobacter pylori detection and antimicrobial susceptibility testing. Clinical Microbiology Reviews, 20, 280-283.
81. Meurer, L. N. & Bower. D. J. (2002). Management of Helicobacter pylori infection. American Family Physician, 65, 7.
82. Meyer, J. J. M., Afolayan, A. J., Taylor, M. B. & Erasmus, D. (1997). Antiviral activity of galangdin isolated from the aerial parts of Helichrysium aureonitens. Journal of Ethnopharmacology, 56, 165-169.
83. Miorin, P. L, Levy Jr, N. C., Custodio, A. R., Bretz, W. A. & Marcucci, M. C. (2003). Antibacterial activity of honey and propolis from Apis mellifera and Tetragonisca angustula against Staphylococcus aureus. Journal of Applied Microbiology, 95, 913-920.
84. Mitchell, H. M., Lee, A. & Carrick, J. (1989). Increased incidence of Campylobacter pylori infection in gastroenterologists: further evidence to support person to person transmission of C. pylori. Scandinavian Journal of Gastroenterology, 24, 396-400.
85. Mohammad, F. & Mohammad, H.P.(2007). A study on the healing effect of honey on infected open wounds. Pakistan Journal of Medical Sciences, 23, 327-329.
86. Mosane, T. W., Malope, B. I., Ratshikhopha, M. E., Hiss, D. C. & Sitas, F. (2004). Seroprevalence of Helicobacter pylori IgG antibodies in South African mothers and their children. European Journal of Gastroenterology and Hepatology, 16, 113-114.
87. Nabwera, H. M., Nguyen-Van-Tam, J. S., Logan, R. F. & Logan, R. P. (2000). Prevalence of Helicobacter pylori in Kenyan school children aged 3-15 years and risk factors for infection. European Journal of Gastroenterology and Hepatology, 12, 483-487.
88. Namias, N. (2003). Honey in the management of infections. Surgical Infections, 4, 219-226.
89. Ndayisaba, G., Bazira, L. & Habonimana, E. (1992). Treatment of wounds with honey. 40 cases. Presse Médicale, 21, 1516-1518.
90. Ndip, R. N., MacKay, W. G., Farthing, M. J. G. & Weaver, L. T. (2003). Culturing Helicobacter pylori from clinical specimens: review of microbiologic methods. Journal of Pediatric Gastroenterology and Nutrition, 36, 616-622.
91. Ndip, R. N., Malange, A. E., Akoachere, J. F. T., Mackay, W. G., Titanji, V. P. K. & Weaver, L. T. (2004). Helicobacter antigens in faeces of asymptomatic children in the Buea and Limbe health districts of Cameroon: a pilot study. Tropical Medicine and International Health, 9, 1036-1040.
92. Ndip, R. N., Dilonga, H. M., Ndip, L. M., Akoachere, J. F. K. & Nkuo-Akenji, T. (2005). Pseudomonas aeruginosa isolates recovered from clinical isolates and environmental samples in Buea, Cameroon: current status on biotyping and antibiogram. Tropical Medicine and International Health, 10, 74-81.
93. Ndip, R. N., Malange Takang, A. E., Echakachi, C. M., Malongue, A. Akoachere, J-F. T. K., Ndip, L. M. & Luma, H. N. (2007a). In-vitro antimicrobial activity of selected honeys on clinical isolates of Helicobacter pylori. African Health Sciences, 7, 228-231.
94. Ndip, R. N., Malange Tarkang, A. E., Mbullah, S. M., Luma, H. N., Malongue, A., Ndip, L. M., Wirmum, C. & Efange, S. M. N. (2007b). In vitro anti- Helicobacter pylori activity of extracts of selected medicinal plants from north west Cameroon. Journal of Ethnopharmacology, 114, 452-457.
95. Ndip, R. N., Malange Takang, A. E., Ojongokpoko, J. E. A., Luma, H., N., Malongue, A., Akoachere, J-F. T. K., Ndip, L. M., MacMillan, M. & Weaver, L. T. (2008). Helicobacter pylori isolates recovered from gastric biopsies of patients with gastro-duodenal pathologies in Cameroon: current status of antibiogram. Tropical Medicine and International Health, 13, 848-854.
96. O'Connor, H. J., Kanduru, C. & Bhutta, A. S. (1995). Effects of Helicobacter pylori eradication on peptic ulcer healing. Postgraduate Medical Journal, 71, 90-93.
97. O'Gara, E. A., Hill, D. J. & Maslin, D. J. (2000). Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. Applied and Environmental Microbiology, 66, 2269-2273.
98. Ogbeche, A. K., Ajayi, G. O. & Onyeneta, P. (1997). Antibacterial activities of the leaf extract of Ageratum conyzoides. Nigerian Quarterly Journal of Hospital Medicine, 7, 397-399.
99. Palmer, D. D., Watson, K. R. & Allen, M. J. (1994). Helicobacter pylori infection and peptic ulcer disease in Cameroon, West Africa. Journal of Clinical Gastroenterology, 18, 162-164.
100. Parsonnet, J., Friedman, C. D., Danel, M. S., Vandersteen, D. P., Chang, Y., Vogetman, J. H., Orentreich, N. & Sibley, R. K. (1991). Helicobacter pylori infection and the risk of gastric carcinoma. New England Journal of Medicine, 325, 1127-1131.
101. Patton, T., Barrett, J., Brennan, J. & Moran, N. (2006). Use of a spectrophotometric bioassay determination of microbial sensitivity to manuka honey. Journal of Microbiological Methods, 64, 84-95.
102. Pelser, H. H., Househam, K. C., Joubert, G., van der Linde, G., Kraaij, P., Meinardi, M., McLeod, A. & Anthony, M. (1997). Prevalence of Helicobacter pylori antibodies in children in Bloemfontein, South Africa. Journal of Pediatric Gastroenterology and Nutrition, 24, 135-139.
103. Perez-Perez, G. L., Witskin, S. S., Decker, M. D. & Blaser, M. J. (1991). Seroprevalence of Helicobacter pylori infection in couples. Journal of Clinical Microbiology, 29, 642-644.
104. Pilotto, A., Rassu, M., Leandro, G., Franceschi, M. & di Mario, F. (2000). Prevalence of Helicobacter pylori resistance to antibiotics in northeast Italy: a multicentre study. GISU. Interdisciplinary Group for the Study of Ulcer. Digestive and Liver Disease, 32, 763-768.
105. Plotkin, M. J. (1988). Conservation, ethnobotany, and the search for new jungle medicines: pharmacognosy comes of age again. Pharmacotherapy, 8, 257-262.
106. Rauws, E. A., Langenberg, W., Houthoff, H. J., Zanen, H. C. & Tytgat, G. N. (1988). Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Gastroenterology, 94, 33-40.
107. Said Essa, A., Alaa Eldeen Nouh, M., Mohammed Ghaniam, N., Graham,D. Y. & Said Sabry, H. (2008). Prevalence of cagA in relation to clinical presentation of Helicobacter pylori infection in Egypt. Scandinavian Journal of Infectious Diseases, 40, 730-733.
108. Salcedo, J. A. & Al-Kawas, F. (1998). Treatment of Helicobacter pylori infection. Archives of Internal Medicine, 158, 842-851.
109. Samie, A., Obi, C. L, Barrett, L. J., Powell, S. M. & Guerrant, R. L. (2007). Prevalence of Campylobacter species, Helicobacter pylori and Arcobacter species in stool samples from the Venda region, Limpopo, South Africa: studies using molecular diagnostic methods. Journal of Infectious Diseases, 54, 558-566.
110. Saridaki-Papakonstadinou, A., Andredakis, S., Burriel, A. & Tsada, I. (2006). Determination of tetracyline residues in Greek honey. Trakia Journal of Sciences, 4, 33-36.
111. Schippmann, U., Leaman, D. J. & Cunningham, A. B. (2002). Impact of cultivation and gathering of medicinal plants on biodiversity: global trends and issues. In Biodiversity and the Ecosystem Approach in Agriculture, Forestry and Fisheries. Satellite Event on the Occasion of the Ninth Regular Session of the Commission on Genetic Resources for Food and Agriculture. Rome, 12-13 October 2002, unnumbered. Rome: Food and Agriculture Organization.
112. Segal, I., Ally, R. & Mitchell, H. (2001). Helicobacter pylori: an African perspective. Quarterly Journal of Medicine, 94, 561-565.
113. Shepherd, A. J., Williams, C. L., Doherty, C. P., Hossack, M., Preston, T., McColl, K. E. L. & Weaver, L. T. (2000). Comparison of an enzyme immunoassay for the detection of Helicobacter pylori antigens in the faeces with the urea breath test. Archives of Disease in Childhood, 83, 268-270.
114. Shepherd, A. J., Malcolm, C., MacKay, W. G. & Weaver, L. T. (2004). Childhood H. pylori: disappearing disease or chronic infection? British Journal of Community Nursing, 9, 201-205.
115. Sherif, M., Mohran, Z., Fathy, H., Rockabrand, D. M., Rozmajzi, P. J. & Frenck, R. W. (2004). Universal high-level primary metronidazole resistance in Helicobacter pylori isolated from children in Egypt. Journal of Clinical Microbiology, 42, 4832-4834.
116. Simon, A., Traynor, K., Santos, K., Blasser, G., Bode, U., Molan, P. (2009). Medical honey for wound care C still the 'latest resort'? Evidence-based Complementary and Alternative Medicine, in press.
117. Singh, D. (2000). A focus on honeybees in the tropics. Current Science, 79, 1155-1157.
118. Smith, S. I., Oyedeji, K. S., Arigbabu, A. O., Atimomo, C. & Coker, A. O. (2001). High amoxicillin resistance in Helicobacter pylori from gastritis and peptic ulcer patients in western Nigeria. Journal of Gastroenterology, 36, 67-68.
119. Sobala, G. M., Crabtree, J. E., Dixon, M. F., Schorah, C. J., Taylor, J. D., Rathbone, B. J., Heatley, R. V. & Axon, A. T. (1991). Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations. Gut, 32, 1415-1418.
120. Sofowara, A. (1993). Medicinal Plants and Traditional Medicine in Africa, 4th Edn. Ibadan, Nigeria: Spectrum Books.
121. Somal, N. A., Coley, K. E., Molan, P. C. & Hancock, B. M. (1994). Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey. Journal of the Royal Society of Medicine, 87, 9-12.
122. Suerbaum, S. & Michetti, P. (2002). Helicobacter pylori infection. New England Journal of Medicine, 347, 1175-1186.
123. Tabuti, J. R. S., Dhillion, S. S. & Lye, K. A. (2003). Traditional medicines in Bulamogi county, Uganda: its practitioners, users and viability. Journal of Ethnopharmacology, 85, 119-129.
124. Thomas, J. E., Gibon, G. R., Darboe, M. K., Dule, A. & Weaver, L. T. (1992). Isolation of Helicobacter pylori from human faeces. Lancet, 340, 1194-1195.
125. Tonks, A. J., Cooper, R. A., Jones, K. P., Blair, S., Parton, J. & Tonks, A. (2003). Honey stimulates inflammatory cytokine production from monocytes. Cytokine, 721, 242-247.
126. Triantafyllopoulou, M. (2006). H. pylori Infection. Chicago, IL: Children's Memorial Hospital, Northwestern University.
127. Tshikalange, T. E., Meyer, J. J. M. & Hussein, A. A. (2005). Antimicrobial activity, toxicity and the isolation of a bioactive compound from plants used to treat sexually transmitted diseases. Journal of Ethnopharmacology, 96, 515-519
128. Tytgat, G. N. (1995). Endoscopic transmission of Helicobacter pylori. Alimentary Pharmacology and Therapeutics, 9, 105-110.
129. Wang, W. H., Wong, B. C., Mukhopadhyay, A. K., Berg, D. E., Cho, C. H., Lai, K. C., Hu, W. H., Fung, F. M., Hui, W. M. & Lam, S. K. (2000). High prevalence of Helicobacter pylori infection with dual resistance to metronidazole and clarithromycin in Hong Kong. Alimentary Pharmacology and Therapeutics, 14, 901-910.
130. Warren, J. R. & Marshall, B. J. (1983). Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet, i, 1273-1275.
131. Welter-Schultes, W. (1992). Notes on the taxonomy of Albinaria of Nisos Dia, Crete (Gastropoda: Clausiliidae). Biologia Gallo-hellenica, 19, 55-61.
132. Westh, H., Zinn, C. S. & Rosdahl, V. T. (2004). An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries. Microbial Drug Resistance, 10, 169-176.
133. Williams, M. P., Sercombe, J. C., Lawson, A. J., Slater, E., Owen, R. J. & Pounder, R. E. (1999). The effect of omeprazole dosing on the isolation of Helicobacter pylori from gastric aspirates. Alimentary Pharmacology and Therapeutics, 13, 1161-1169.
134. World Health Organization (1987). Report of the Second Meeting of Directors of WHO Collaborating Centres for Traditional Medicine. Document WHO/TRM/88.1. Geneva: WHO.
135. Wösten, M. M. S. M., Ishiguro, E. E. & van der Zeijst, B. A. M. (1997). Cloning and characterization of the lytB gene of Campylobacter jejuni. FEMS Microbiology Letters, 157, 117-121.
136. Yoshimura, N. (2001). A 13C-urea breath test in children with Helicobacter pylori infection: assessment of eradication therapy and follow-up after treatment. Journal of Gastroenterology, 36, 606-611.
137. Youri, G. (1998). Microbiological and serological diagnostic tests for Helicobacter pylori: an overview. British Medical Bulletin, 54, 175-186.
138. Zaghloul, A. A., Shattawy, H. H. E., Kassem, A. A., Reddy, I. K. & Khan, M. A. (2001). Honey, a prospective antibiotic: extraction, formulation, and stability. Pharmazie, 56, 643-647.