Amelioration of glucose intolerance by the synthetic androstene HE3286: Link to inflammatory pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 333, Issue 1, 2010, Pages 70-80

  Wang, Tianlun ^a   Villegas, Sonia ^a   Huang, Yujin ^a   White, Steve K ^a   Ahlem, Clarence ^a   Lu, Min ^b   Olefsky, Jerrold M ^b   Reading, Chris ^a   Frincke, James M ^a   Alleva, David ^a   Flores Riveros, Jaime ^a  

^a Hollis Eden Pharmaceuticals Inc   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5ALPHA ANDROSTANE 3BETA, 7BETA, 17BETA TRIOL; ANDROGEN RECEPTOR; ANDROSTANE DERIVATIVE; CELL NUCLEUS RECEPTOR; CHEMOKINE RECEPTOR; CORTICOSTEROID RECEPTOR; ENDOTOXIN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOCORTICOID RECEPTOR; GLUCOSE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; LIGAND; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOTRANSFERASE; PROGESTERONE RECEPTOR; ROSIGLITAZONE; SERINE; SEX HORMONE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; C57BL 6 MOUSE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MODEL; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE TRANSLOCATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RECEPTOR BINDING; REPORTER GENE; SIGNAL TRANSDUCTION; THERAPY EFFECT; TRANSACTIVATION; WHITE ADIPOSE TISSUE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; DEHYDROEPIANDROSTERONE; GENE EXPRESSION PROFILING; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; PHOSPHORYLATION; RECEPTORS, STEROID;

EID: 77949688579     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.161182     Document Type: Article

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