Elderly Patients With Painful Bone Metastases Should be Offered Palliative Radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 76, Issue 5, 2010, Pages 1500-1506

  Campos, Sarah ^a   Presutti, Roseanna ^a   Zhang, Liying ^a   Salvo, Nadia ^a   Hird, Amanda ^a   Tsao, May ^a   Barnes, Elizabeth A ^a   Danjoux, Cyril ^a   Sahgal, Arjun ^a   Mitera, Gunita ^a   Sinclair, Emily ^a   DeAngelis, Carlo ^a   Nguyen, Janet ^a   Napolskikh, Julie ^a   Chow, Edward ^a  

^a DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

Author keywords

bone metastases; Elderly; radiotherapy

Indexed keywords

BONE METASTASES; BONE METASTASIS; DEMOGRAPHIC INFORMATION; PALLIATIVE RADIOTHERAPY; PERFORMANCE STATUS; RESPONSE RATE; WORKING PARTIES;

ENZYME INHIBITION; PATHOLOGY; RADIOTHERAPY;

BONE;

ANALGESIC AGENT; MORPHINE;

ADULT; AGED; AGING; ARTICLE; BONE METASTASIS; BONE PAIN; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CLINICAL TRIAL; CONSENSUS; CONTROLLED STUDY; DEMOGRAPHY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; PALLIATIVE THERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANALGESICS; BONE NEOPLASMS; FEMALE; HUMANS; KARNOFSKY PERFORMANCE STATUS; MALE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PALLIATIVE CARE;

EID: 77949666335     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.03.019     Document Type: Article

References (64)

1. Canadian Cancer Society/National Cancer Institute of Canada. Canadian cancer statistics 2008 (2008), Canadian Cancer Society/National Cancer Institute of Canada, Toronto, Canada
2. Firvida J.L., Vinolas N., Munoz M., et al. Age: A critical factor in cancer management. A prospective comparative study of 400 patients. Age Ageing 28 (1999) 103-105
3. Yancik R., Wesley M.N., Ries L.A., et al. Comorbidity and age as predictors of risk for early mortality of male and female colon carcinoma patients: A population-based study. Cancer 82 (1998) 2123-2134
4. Yancik R. Cancer burden in the aged: An epidemiologic and demographic overview. Cancer 80 (1997) 1273-1283
5. Extermann M., Balducci L., and Lyman G.H. What threshold for adjuvant therapy in older breast cancer patients?. J Clin Oncol 18 (2000) 1709-1717
6. Rogatko A., Babb J.S., Wang H., et al. Patient characteristics compete with dose as predictors of acute treatment toxicity in early phase clinical trials. Clin Cancer Res 10 (2004) 4645-4651
7. Freyer G., Geay J.F., Touzet S., et al. Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: A GINECO study. Ann Oncol 16 (2005) 1795-1800
8. Ludbrook J.J., Truong P.T., MacNeil M.V., et al. Do age and comorbidity impact treatment allocation and outcomes in limited stage small-cell lung cancer? A community-based population analysis. Int J Radiat Oncol Biol Phys 55 (2003) 1321-1330
9. Frasci G., Lorusso V., Panza N., et al. Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer. J Clin Oncol 18 (2000) 2529-2536
10. Satariano W.A., and Ragland D.R. The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med 120 (1994) 104-110
11. Yancik R., Wesley M.N., Ries L.A., et al. Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. JAMA 285 (2001) 885-892
12. Bergman L., Kluck H.M., van Leeuwen F.E., et al. The influence of age on treatment choice and survival of elderly breast cancer patients in South-Eastern Netherlands: A population-based study. Eur J Cancer 28A (1992) 1475-1480
13. Dale D.C. Poor prognosis in elderly patients with cancer: The role of bias and undertreatment. J Supportive Oncol 1 4 Suppl. 2 (2003) 11-17
14. Muss H.B., Woolf S., Berry D., et al. Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer. JAMA 293 (2005) 1073-1081
15. de Jong B., Crommelin M., van der Heijden L.H., et al. Patterns of radiotherapy for cancer patients in South-Eastern Netherlands, 1975-1989. Radiother Oncol 31 (1994) 213-221
16. Du X.L., Key C.R., Osborne C., et al. Discrepancy between consensus recommendations and actual community use of adjuvant chemotherapy in women with breast cancer. Ann Intern Med 138 (2003) 90-97
17. Denis L.J., Murphy G.P., and Schroder F.H. Report of the consensus workshop on screening and global strategy for prostate cancer. Cancer 75 (1995) 1187-1207
18. Huang J., Zhou S., Groome P., et al. Factors affecting the use of palliative radiotherapy in Ontario. J Clin Oncol 19 (2001) 137-144
19. Martin L.M., le Pechoux C., Calitchi E., et al. Management of breast cancer in the elderly. Eur J Cancer 30A (1994) 590-596
20. Morrow M. Breast disease in elderly women. Surg Clin North Am 74 (1994) 145-161
21. Mor V., Masterson-Allen S., Goldberg R.J., et al. Relationship between age at diagnosis and treatments received by cancer patients. J Am Geriatr Soc 33 (1985) 585-589
22. Tyldesley S., Zhang-Salomons J., Groome P.A., et al. Association between age and the utilization of radiotherapy in Ontario. Int J Radiat Oncol Biol Phys 47 (2000) 469-480
23. Balducci L. The geriatric cancer patient: Equal benefit from equal treatment. Cancer Control 8 2 Suppl (2001) 1-25 quiz 27-28
24. Peake M.D., Thompson S., Lowe D., et al. Ageism in the management of lung cancer. Age Ageing 32 (2003) 171-177
25. Lewis J.H., Kilgore M.L., Goldman D.P., et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol 21 (2003) 1383-1389
26. Yee K.W., Pater J.L., Pho L., et al. Enrollment of older patients in cancer treatment trial in Canada: Why is age a barrier?. J Clin Oncol 21 (2003) 1618-1623
27. Siu L. Clinical trials in the elderly-A concept comes of age. N Engl J Med 356 (2007) 1527-1535
28. InSightec Image Guided Treatment Ltd. Pain palliation of bone metastases-Overview. Available from: InSightec.com [homepage on the Internet]; http://www.insightec.com/135-en-r10/BoneMetastases.aspx. Accessed April 1, 2005.
29. Cleeland C.S. Undertreatment of cancer pain in elderly patients. JAMA 279 (1998) 1914-1915
30. Coleman R.E. Metastatic bone disease: Clinical features, pathophysiology and treatment strategies. Cancer Treat Rev 27 (2001) 165-176
31. Harrington K.D. Impending pathologic fractures from metastatic malignancy: Evaluation and management. In: Anderson L.D. (Ed). AAOS instructional course lectures (1986), CV Mosby, St. Louis 357-380
32. Chow E., Harris K., Fan G., et al. Palliative radiotherapy trials for bone metastases: A systematic review. J Clin Oncol 25 (2007) 1423-1436
33. Chow E., Wong R., Hruby G., et al. Prospective patient-based assessment of effectiveness of palliative radiotherapy for bone metastases. Radiother Oncol 61 (2001) 77-82
34. Nielsen O.S. Palliative radiotherapy of bone metastases: There is now evidence for the use of single fractions. Radiother Oncol 52 (1999) 95-96
35. Berk L. Prospective trials for the radiotherapeutic treatment of bone metastases. Am J Hospice Palliat Med 12 (1995) 24-28
36. Pignon T., and Scalliet P. Radiotherapy in the elderly. Eur J Surg Oncol 24 (1998) 407-411
37. Zachariah B., Balducci L., Venkattaramanabalaji G.V., et al. Radiotherapy for cancer patients aged 80 and older: A study of effectiveness and side effects. Int J Radiat Oncol Biol Phys 39 (1997) 1125-1129
38. Souchon R. [Palliative radiation oncologic therapy: Is patient's age a determining factor of feasibility? A 1-year analysis (1997) at a radiotherapy clinic of an academic teaching hospital]. Strahlenther Onkol 175 (1999) 218-224
39. Mitsuhashi N., Hayakawa K., Yamakawa M., et al. Cancer in patients aged 90 years or older: Radiation therapy. Radiology 211 (1999) 829-833
40. Pignon T., Gregor A., Schaake Koning C., et al. Age has no impact on acute and late toxicity of curative thoracic radiotherapy. Radiother Oncol 46 (1998) 239-248
41. Quon H., Shepherd F.A., Payne D.G., et al. The influence of age on the delivery, tolerance, and efficacy of thoracic irradiation in the combined modality treatment of limited stage small cell lung cancer. Int J Radiat Oncol Biol Phys 43 (1999) 39-45
42. Donato V., Valeriani M., and Zurlo A. Short course radiation therapy for elderly cancer patients: Evidence from the literature review. Crit Rev Oncol Hematol 45 (2003) 305-311
43. Danjoux C., Chow E., Drossos A., et al. An innovative rapid response radiotherapy program to reduce waiting time for palliative radiotherapy. Support Care Cancer 14 (2006) 38-43
44. Chang V.T., Hwang S.S., and Feuerman M. Validation of the Edmonton Symptom Assessment Scale. Cancer 88 (2000) 2164-2171
45. Klepstad P., Loge J.H., Borchgrevink P.C., et al. The Norwegian brief pain inventory questionnaire: Translation and validation in cancer pain patients. J Pain Symptom Manage 24 (2002) 517-525
46. Berdine H.J., and Nesbit S.A. Equianalgesic dosing of opioids. J Pain Palliat Care Pharmacother 20 (2006) 79-84
47. Souter K.J., and Fitzgibbon D. Equianalgesic dose guidelines for long-term opioid use: Theoretical and practical considerations. Perioper Med Pain 23 (2004) 271-280
48. Gammaitoni A.R., Fine P., Alvarez N., et al. Clinical application of opioid equianalgesic data. Clin J Pain 19 (2003) 286-297
49. Harris K., Li K., Flynn C., et al. Worst, average or current pain in the brief pain inventory: Which should be used to calculate the response to palliative radiotherapy in patients with bone metastases?. Clin Oncol (R Coll Radiol) 19 (2007) 523-527
50. Chow E., Wu J.S., Hoskin P., et al. International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol 64 (2002) 275-280
51. Oguchi M., Ikeda H., Watanabe T., et al. Experiences of 23 patients > or = 90 years of age treated with radiation therapy. Int J Radiat Oncol Biol Phys 41 (1998) 407-413
52. Carreca I., Balducci L., and Extermann M. Cancer in the older person. Cancer Treat Rev 31 (2005) 380-402
53. Bouchardy C., Rapiti E., Blagojevic S., et al. Older female cancer patients: Importance, causes, and consequences of undertreatment. J Clin Oncol 25 (2007) 1858-1869
54. Steenland E., Leer J.W., van Houwelingen H., et al. The effect of a single fraction compared to multiple fractions on painful bone metastases: A global analysis of the Dutch Bone Metastasis study. Radiother Oncol 52 (1999) 101-109
55. Nielsen O.S., Bentzen S.M., Sandberg E., et al. Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases. Radiother Oncol 47 (1998) 233-240
56. Rasmusson B., Vejborg I., Jensen A.B., et al. Irradiation of bone metastases in breast cancer patients: A randomized study with 1 year follow-up. Radiother Oncol 34 (1995) 179-184
57. Price P., Hoskin P.J., Easton D., et al. Prospective randomized trial of single and multifraction radiotherapy schedules in the treatment of painful bony metastases. Radiother Oncol 6 (1986) 247-255
58. Bradley N.M., Husted J., Sey M.S., et al. Did the pattern of practice in the prescription of palliative radiotherapy for the treatment of uncomplicated bone metastases change between 1999 and 2005 at the rapid response radiotherapy program?. Clin Oncol 20 (2008) 327-336
59. Government of Canada. Canada Health Act (1985), Government of Canada, Ottawa S. C-6
60. Townsley C.A., Naidoo K., Pond G.R., et al. Are older cancer patients being referred to oncologists? A mail questionnaire of Ontario primary care practitioners to evaluate their referral patterns. J Clin Oncol 21 (2003) 4627-4635
61. Votron L., D'Hoore W., Swine C., et al. The opinion of general practitioners on the treatment of prostate and breast cancer in elderly people: Results of a survey based on clinical models. Clin Oncol (R Coll Radiol) 16 (2004) 474-478
62. Glare P.A., and Sinclair C.T. Palliative medicine review: Prognostication. J Palliat Med 11 (2008) 84-103
63. Chow E., Harris K., Fan G., et al. Palliative radiotherapy trials for bone metastases: A systematic Review. J Clin Oncol 25 (2007) 1423-1436
64. Chow E., Davis L., Holden L., et al. A comparison of radiotherapy outcomes of bone metastases employing international consensus endpoints and traditional endpoints. Support Cancer Ther 1 (2004) 173-178