Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases

Radiotherapy and Oncology

Volumn 47, Issue 3, 1998, Pages 233-240

  Nielsen, Ole Steen ^a   Bentzen, Søren M ^a   Sandberg, Erik ^b   Gadeberg, Carl C ^c   Timothy, Adrian R ^d  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Esbjerg Sygehus   (Denmark)

^c LILLEBAELT HOSPITAL   (Denmark)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Bone metastasis; Pain relief; Palliation; Quality of life; Radiotherapy

Indexed keywords

ADULT; AGED; ARTICLE; BONE METASTASIS; BREAST CANCER; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; LUNG TUMOR; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PROSTATE CANCER; QUALITY OF LIFE; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; BONE NEOPLASMS; BREAST NEOPLASMS; DOSE FRACTIONATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MORPHINE; PAIN; PAIN MEASUREMENT; PALLIATIVE CARE; PROSPECTIVE STUDIES; PROSTATIC NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 0031745945     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(98)00011-5     Document Type: Article

References (22)

1. Aaronson, N.K., Ahmedzai, S., Bergman, B., et al. The European Organization for Research and Treatment of Cancer QLQ C-30: a quality-of-life instrument for use in international clinical trials in oncology. J. Natl. Cancer Inst. 85: 365-376, 1993.
2. Barak, F., Werner, A., Walach, N. and Horn, Y. The palliative efficacy of a single high dose of radiation in treatment of symptomatic osseous metastases. Int. J. Radiat. Oncol. Biol. Phys. 13: 1233-1235, 1987.
3. Bates, T., Yarnold, J.R., Blitzer, P., Nielsen, O.S., Rubin, P. and Maher, J. Bone metastases consensus statement. Int. J. Radiat. Oncol. Biol. Phys. 23: 215-216, 1992.
4. Blitzer, P.H. Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis. Cancer 55: 1468-1472, 1985.
5. Gaze, M.N., Kelly, C.G., Kerr, G.R., et al. Pain relief and quality of life following radiotherapy for bone metastases: a randomized trial of two fractionation schedules. Radiother. Oncol. 45: 109-116, 1997.
6. Hoskin, P.J., Price, P., Easton, D., et al. A prospective randomized trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain. Radiother. Oncol. 23: 74-78, 1992.
7. Madsen, E.L. Painful bone metastasis: efficacy of radiotherapy assessed by the patients: a randomised trial comparing 4 Gy x6 versus 10 Gy x2. Int. J. Radiat. Oncol. Biol. Phys. 9: 1775-1779, 1983.
8. McQuay, H.J., Carroll, D. and Moore, R.A. Radiotherapy for painful bone metastases: a systematic review. Clin. Oncol. 9: 150-154, 1997.
9. Mithal, N.P., Needham, P.R. and Hoskin, P.J. Retreatment with radiotherapy for bone metastases. Int. J. Radiat. Oncol. Biol. Phys. 29: 1011-1014, 1994.
10. Nielsen, O.S. Palliative treatment of bone metastases. Acta Oncol. 35 (Suppl. 5): 58-60, 1996.
11. Nielsen, O.S., Munro, A.J. and Tannock, I.E. Bone metastases -pathophysiology and management policy. J. Clin. Oncol. 9: 509-524, 1991.
12. Niewald, M., Tkocz, H.-J., Abel, U., et al. Rapid course radiation therapy vs. more standard treatment: a randomized trial for bone metastases. Int. J. Radiat. Biol. Phys. 36: 1085-1089, 1996.
13. Porter, A.T., McEwan, A.J.B., Powe, J.E., et al. Results of a rando3 mized phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external irradiation in the management of endocrine resistant metastatic prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 25: 805-813, 1993.
14. Porter, A.T. and Fontanesi, J. Palliative irradiation for bone metastases - a new paradigm. Int. J. Radiat. Oncol. Biol. Phys. 29: 1199-1200, 1994.
15. Poulsen, H.S., Nielsen, O.S., Klee, M. and Rørth, M. Palliative irradiation of bone metastases. Cancer Treat. Rev. 16: 41-48, 1989.
16. Poulter, C.A., Cosmatos, D., Rubin, P., et al. A report of RTOG 8206: a phase III study of whether the addition of single dose hemi-body irradiation to standard fractionated local field irradiation is more effective than local field irradiation alone in the treatment of symptomatic osseous metastases. Int. J. Radiat. Oncol. Biol. Phys. 23: 207-214, 1992.
17. Price, P., Hoskin, P.J., Easton, D., Austin, D., Palmer, S.G. and Yarnold, J.R. Prospective randomised trial of single and multifraction radiotherapy schedules in the treatment of painful bony metastases. Radiother. Oncol. 6: 247-255, 1986.
18. Quilty, P.M., Kirk, D., Bolger, J.J., et al. A comparison of the palliative effect of strontium-89 and external beam radiotherapy in metastatic prostate cancer. Radiother. Oncol. 31: 33-40, 1994.
19. Rasmusson, B., Vejborg, I., Jensen, A.B., et al. Irradiation of bone metastases in breast cancer patients: a randomized study with 1 year follow-up. Radiother. Oncol. 34: 179-184, 1995.
20. Rubens, R.D. and Coleman, R.E. Bone metastases. In: Clinical Oncology, pp. 643-665. Editors: M.D. Abeloff, J.O. Armitage, A.S. Lichter and J.E. Niederhuber. Churchill Livingstone, New York, 1995.
21. Tong, D., Gillick, L. and Hendrickson, F.R. The palliation of symptomatic osseous metastases. Final results of the study by the Radiation Therapy Oncology Group. Cancer 50: 893-899, 1982.
22. Uppelschoten, J.M., Wanders, S.L. and de Jong, J.M.A. Single-dose radiotherapy (6 Gy): palliation in painful bone metastases. Radiother. Oncol. 36: 198-202, 1995.