The effect of a single fraction compared to multiple fractions on painful bone metastases: A global analysis of the Dutch Bone Metastasis Study

Radiotherapy and Oncology

Volumn 52, Issue 2, 1999, Pages 101-109

  Steenland, Elsbeth ^b   Leer, Jan ^a   Van Houwelingen, Hans ^b   Post, Wendy J ^b   Van den Hout, Wilbert B ^b   Kievit, Job ^b   De Haes, Hanneke ^b   Martijn, Hendrik ^b   Oei, Bing ^b   Vonk, Ernest ^b   Van der Steen Banasik, Elzbieta ^b   Wiggenraad, Ruud G J ^b   Hoogenhout, Jaap ^b   Wárlám Rodenhuis, Carla ^b   Van Tienhoven, Geertjan ^b   Wanders, Rinus ^b   Pomp, Jacqueline ^b   Van Reijn, M ^b   Van Mierlo, Thijs ^b   Rutten, Ewald ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

Bone metastasis; Costs; Pain relief; Palliation; Radiotherapy

Indexed keywords

ADULT; AGED; ANALGESIA; ARTICLE; BONE METASTASIS; BONE PAIN; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST BENEFIT ANALYSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOLOGIC FRACTURE; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RADIATION DOSE FRACTIONATION; RADIATION ENTEROPATHY; RADIATION SICKNESS; RANDOMIZED CONTROLLED TRIAL; SPINAL CORD COMPRESSION; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; BONE NEOPLASMS; DISEASE PROGRESSION; DOSE FRACTIONATION; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN; PALLIATIVE CARE; QUALITY OF LIFE; QUESTIONNAIRES; RADIOTHERAPY; RADIOTHERAPY DOSAGE; SURVIVAL RATE;

EID: 0033179896     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(99)00110-3     Document Type: Article

References (16)

1. Arcangeli G., Micheli A., Arcangeli G., et al. The responsiveness of bone metastases to radiotherapy: The effect of site, histology and radiation dose on pain relief. Radiother. Oncol. 14:1989;95-101.
2. Arcangeli G., Giovinazzo G., Saracino B., et al. Radiation therapy in the management of symptomatic bone metastases: The effect of total dose and histology on pain relief and response duration. Int. J. Rad. Oncol. Biol. Phys. 42:1998;1119-1126.
3. Bates T. A review of local therapy in the treatment of bone metastases and cord compression. Int. J. Rad. Oncol. Biol. Phys. 23:1992;217-221.
4. Blitzer P.H. Reanalysis of the RTOG study of the palliation of symptomatic osseous metastasis. Cancer. 55:1985;1468-1472.
5. De Haes J.C.J.M., Olschewski M., Fayers P., et al. Measuring the quality of life of cancer patients with the Rotterdam Symptom Checklist (RSCL): A manual. 1996;Northern Centre for Healthcare Research.
6. Gaze M.N., Kelly C.G., Kerr G.R., et al. Pain relief and quality of life following radiotherapy for bone metastases: A randomised trial of two fractionation schedules. Radiother. Oncol. 45:1997;109-116.
7. Hoskin P.J. Scientific and clinical aspects of radiotherapy in the relief of bone pain. Cancer Surveys. 7:1988;69-86.
8. Hoskin P.J., Price P., Easton D. A prospective randomised trial of 4 Gy or 8 Gy single doses in treatment of metastatic bone pains. Radiother. Oncol. 23:1992;74-78.
9. Jensen M.P., Karoly P., Braver S. The measurement of clinical pain intensity: A comparison of six methods. Pain. 27:1986;117-126.
10. Nielsen O.S. Palliative treatment of bone metastases. Acta Oncol. 35:1996;58-60.
11. Nielsen O.S., Bentzen S.M., Sandberg E., Gadeberg C.C., Timothy A.R. Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases. Radiother. Oncol. 47:1998;233-240.
12. Price P., Hoskin P.J., Easton D., Austin D., Palmer S.G., Yarnold J.R. Prospective randomised trial of single and multifraction radiotherapy schedules in the treatment of painful bony metastases. Radiother. Oncol. 6:1986;247-255.
13. Ratanatharathorn V., Powers W.E., Moss W.T., Perez C.A. Bone metastasis: Review and critical analysis of random allocation trials of local field treatment. Int. J. Rad. Oncol. Biol. Phys. 44:1999;1-18.
14. Tong D., Gillick L., Hendrickson F. final results of the study by the radiation therapy oncology group. Cancer. 50:1982;893-899.
15. Uppelschoten J.M., Wanders S.L., De Jong J.M.A. Single-dose radiotherapy (6 Gy): Palliation in painful bone metastases. Radiother. Oncol. 36:1995;198-202.
16. Cancer pain relief. 1986;World Health Organisation, Geneva.