Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: Potential therapeutic for the control of inflammatory chronic pain

Journal of Pharmacy and Pharmacology

Volumn 62, Issue 2, 2010, Pages 205-213

  De Almeida Barros, Taís A ^a,c   De Freitas, Luis A R ^a   Filho, José M B ^b   Nunes, Xirley P ^b   Giulietti, Ana M ^c   De Souza, Glória E ^d   Dos Santos, Ricardo R ^a,e   Soares, Milena B P ^a,e   Villarreal, Cristiane F ^a,f  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Federal University of Paraí ba   (Brazil)

^c DEPARTAMENTO DE CIÊNCIAS BIOLÓGICAS   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e HOSPITAL SÃO RAFAEL   (Brazil)

^f FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

7 hydroxycoumarin; Antiinflammatory; Antinociception; Antipyretic; Chronic pain; Gastric toxicity

Indexed keywords

ACETIC ACID; CARRAGEENAN; FORMALDEHYDE; FREUND ADJUVANT; UMBELLIFERONE; 7-HYDROXYCOUMARIN; NONSTEROID ANTIINFLAMMATORY AGENT; UMBELLIFERONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ANTIPYRETIC ACTIVITY; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DISEASE CONTROL; DRUG SAFETY; FEVER; INFLAMMATION; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PAW EDEMA; RAT; ROTAROD TEST; STOMACH ULCER; TAIL FLICK TEST; ULCEROGENESIS; WRITHING TEST; ACUTE DISEASE; ANIMAL; CHRONIC DISEASE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; EDEMA; MOTOR ACTIVITY; ORAL DRUG ADMINISTRATION; PAIN; PAIN MEASUREMENT; WISTAR RAT;

ACUTE DISEASE; ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FEVER; INFLAMMATION; MALE; MICE; MOTOR ACTIVITY; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; UMBELLIFERONES;

EID: 77949623041     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.62.02.0008     Document Type: Article

References (53)

1. Dubner R, Ruda MA. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 1992 15 : 96 103
2. Strassels SA et al. Pharmacotherapy of pain in older adults. Clin Geriatr Med 2008 24 : 275 298
3. Vane JR et al. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 1998 38 : 97 120
4. Tapiero H et al. Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. Biomed Pharmacother 2002 56 : 215 222
5. Rainsford KD. Anti-inflammatory drugs in the 21st century. Subcell Biochem 2007 42 : 3 27
6. Murray RD. Coumarins. Nat Prod Rep 1989 6 : 591 624
7. Egan D et al. The pharmacology, metabolism, analysis and applications of coumarin and coumarin-related compounds. Drug Metabolism Reviews 1990 22 : 503 529
8. Razavi SM et al. Coumarins from the aerial parts of Prangos uloptera (Apiaceae). Braz J Pharmacogn 2008 18 : 1 5
9. Lake BG. Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem Toxicol 1999 37 : 423 453
10. Wu FJ, Sheu SJ. Analysis and processing of Chinese herbal drugs: the study of Fructus aurantii immaturus (Chin.). Chin Pharmaceut J 1992 44 : 257 263
11. Vasconcelos JF et al. Effects of umbelliferone in a murine model of allergic airway inflammation. Eur J Pharmacol 2009 609 : 126 131
12. Hoult JRS, Paya M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol 1996 27 : 713 722
13. Kofinas C et al. Cytotoxic coumarins from the aqueous parts of Terdyliim apulum and their effects on non small cell bronchial carcinoma cell line. Planta Med 1998 64 : 174 176
14. Lopez-Gonzalez JS et al. Apoptosis and cell cycle disturbances induced by coumarin and 7-hydroxycoumarin on human lung carcinoma cell lines. Lung Cancer 2004 43 : 275 283
15. Ramesh B, Pugalendi KV. Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats. J Med Food 2006 9 : 562 566
16. Marles RJ, Farnsworth N. Antidiabetic plants and their active constituents: an update. Prof J Bot Med 1996 3 : 85 135
17. Chen YF et al. Anti-inflammatory and analgesic activities from roots of Angelica pubescens. Planta Med 1995 61 : 2 8
18. Besson JM. The neurobiology of pain. Lancet 1999 353 : 1610 1615
19. Wang LX, Wang ZJ. Animal and cellular models of chronic pain. Ad Drug Delivery Rev 2003 55 : 949 965
20. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983 16 : 109 110
21. Collier HOJ et al. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 1968 32 : 295 310
22. Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine and brain-stem stimulation in rats and cats. Pain 1977 4 : 161 174
23. Kassuya CA et al. Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. Eur J Pharmacol 2003 478 : 145 153
24. Chaplan SR et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994 53 : 55 63
25. D'Amour FE, Smith DL. A method for determining loss of pain sensation. J Pharmacol Exp Ther 1941 72 : 74 79
26. Gordon CJ. Thermal biology of the laboratory rat. Physiol Behav 1990 47 : 963 991
27. Winter CA et al. Carrageenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc Soc Exp Biol Med 1962 111 : 544 547
28. Laine L, Weinstein WM. Histology of alcoholic hemorrhagicgastritis: a prospective evaluation. Gastroenterology 1988 94 : 1254 1262
29. Trevethick MA et al. Non-steroidal anti-inflammatory drug-induced gastric damage in experimental animals: underlying pathological mechanisms. Gen Pharmacol 1995 26 : 1455 1459
30. Vaz ZR et al. Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6- dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice. J Pharmacol Exp Ther 1996 278 : 304 312
31. Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987 30 : 103 114
32. Shibata M et al. Modified formalin test: characteristic biphasic pain response. Pain 1989 38 : 347 352
33. Jensen TS, Yaksh TL. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial in rat. Brain Res 1986 363 : 99 113
34. Le Bars D et al. Animal models of nociception. Pharmacol Rev 2001 53 : 597 652
35. Bakhle YS, Botting RM. Cyclooxygenase-2 and its regulation in inflammation. Med Inflamm 1996 5 : 305 323
36. Cao C et al. Induction by lipopolysaccharide of COX-2 mRNA in the brain: its possible role in the febrile response. Brain Res 1995 697 : 187 196
37. Cao C et al. Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever. Brain Res 1996 733 : 263 272
38. Lugarini F et al. A role for cyclooxygenase-2 in lipopolysaccharide- induced anorexia in rats. Am J Physiol Regul Integr Comp Physiol 2002 283 : 862 868
39. Fabricio ASC et al. The effects of selective and non-selective cyclooxygenase inhibitors on endothelin-1-induced fever in rats. Am J Physiol Regul Integr Comp Physiol 2005 288 : 671 677
40. Machado RR et al. CCR1 and CCR5 chemokine receptors are involved in fever induced by LPS (E. coli) and RANTES in rats. Brain Res 2007 1161 : 21 31
41. Kim JS et al. Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. Arch Pharm Res 2006 29 : 617 623
42. Lee RE et al. Inhibition of prostaglandin biosynthesis by coumarin, 4-hydroxycoumarin, and 7-hydroxycoumarin. Arzneimittelforschung 1981 31 : 640 642
43. Larson AA et al. Pain threshold changes in adjuvant-induced inflammation: a possible model of chronic pain in the mouse. Pharmacol Biochem Behav 1985 24 : 49 53
44. McCleskey EW, Gold MS. Ion channels of nociception. Annu Rev Physiol 1999 61 : 835 856
45. Basbaum AI. Distinct neurochemical features of acute and persistent pain. Proc Natl Acad Sci USA 1999 96 : 7739 7743
46. Tomaya DO et al. Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom. Toxicon 2009 53 : 417 426
47. Moreira V et al. Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E(2) and D(2) and expression of cyclooxygenases. Toxicon 2008 52 : 428 439
48. Zuliani JP et al. Inflammatory events induced by Lys-49 and Asp-49 phospholipasesA2 isolated from Bothrops asper snake venom: role of catalytic activity. Toxicon 2005 45 : 335 346
49. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971 231 : 232 235
50. Robert A. Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins. Adv Prostaglandin Thromboxane Res 1976 2 : 507 520
51. Peskar BM. On the synthesis of prostaglandins by human gastric mucosa and its modification by drugs. Biochim Biophys Acta 1977 487 : 307 314
52. Allison MC et al. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N Engl J Med 1992 327 : 749 754
53. Sharifi S et al. Pharmacokinetics of coumarin and its metabolites. Preliminary results in three healthy volunteers. J Ir Coll Phys Surg 1993 22 : 29 32