A systematic review of the evidence of reduced allergenicity and clinical benefit of food hydrolysates in dogs with cutaneous adverse food reactions

Veterinary Dermatology

Volumn 21, Issue 1, 2010, Pages 32-41

  Olivry, Thierry ^a   Bizikova, Petra ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANIS FAMILIARIS;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; DERMATITIS; DOG; DOG DISEASE; FOOD ALLERGY; FOOD HANDLING; REVIEW;

ANIMAL FEED; ANIMALS; DERMATITIS; DOG DISEASES; DOGS; FOOD HANDLING; FOOD HYPERSENSITIVITY;

EID: 77949532555     PISSN: 09594493     EISSN: 13653164     Source Type: Journal    
DOI: 10.1111/j.1365-3164.2009.00761.x     Document Type: Review

References (45)

1. White SD. Food hypersensitivity in 30 dogs. Journal: of: the: American: Veterinary: Medical: Association 1986, 188:695-8.
2. Carlotti DN, Remy I, Prost C. Food allergy in dogs and cats. A review and report of 43 cases. Veterinary: Dermatology 1990, 1:55-62.
3. Harvey RG. Food allergy and dietary intolerance in dogs: a report of 25 cases. Journal of Small Animal Practice 1993, 34:175-9.
4. Paterson S. Food hypersensitivity in 20 dogs with skin and gastrointestinal signs. Journal of Small Animal Practice 1995, 36:529-34.
5. Chesney CJ. Systematic review of evidence for the prevalence of food sensitivity in dogs. Veterinary Record 2001, 148:445-8.
6. Chesney CJ. Food sensitivity in the dog: a quantitative study. Journal of Small Animal Practice 2002, 43:203-7.
7. Verlinden A, Hesta M, Millet S. Food allergy in dogs and cats: a review. Critical: Reviews: in: Food: Science: Nutrition 2006, 46:259-73.
8. Hillier A, Griffin CE. The ACVD Task Force on Canine Atopic Dermatitis (X): Is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions? Veterinary: Immunology: Immunopathology 2001, 81:219-26.
9. Ermel RW, Kock M, Griffey SM. The atopic dog - a model for food allergy. Laboratory Animal Science 1997, 47:40-9.
10. Teuber SS, del Val G, Morigasaki S. The atopic dog as a model of peanut and tree nut food allergy. Journal of Allergy and Clinical Immunology 2002, 110:921-7.
11. Buchanan BB, Frick OL. The dog as a model for food allergy. Annals: of: the: New: York: Academy: of: Sciences 2002, 964:173-83.
12. Jackson HA, Hammerberg B. Evaluation of a spontaneous canine model of immunoglobulin E-mediated food hypersensitivity: dynamic changes in serum and fecal allergen-specific immunoglobulin E values relative to dietary change. Comparative: Medicine 2002, 52:316-21.
13. Jackson HA, Jackson MW, Coblentz L. Evaluation of the clinical and allergen specific serum immunoglobulin E responses to oral challenge with cornstarch, corn, soy and a soy hydrolysate diet in dogs with spontaneous food allergy. Veterinary: Dermatology 2003, 14:181-7.
14. Foster AP, Knowles TG, Moore AH. Serum IgE and IgG responses to food antigens in normal and atopic dogs, and dogs with gastrointestinal disease. Veterinary: Immunology: Immunopathology 2003, 92:113-24.
15. Day MJ. The canine model of dietary hypersensitivity. The: Proceedings: of: the: Nutrition: Society 2005, 64:458-64.
16. Ishida R, Masuda K, Sakaguchi M. Antigen-specific histamine release in dogs with food hypersensitivity. Journal of Veterinary Medical Science 2003, 65:435-8.
17. Ishida R, Masuda K, Kurata K. Lymphocyte blastogenic responses to inciting food allergens in dogs with food hypersensitivity. Journal: of: Veterinary: Internal: Medicine 2004, 18:25-30.
18. Olivry T, Kurata K, Paps JS. A blinded randomized controlled trial evaluating the usefulness of a novel diet (aminoprotect care) in dogs with spontaneous food allergy. The: Journal: of: Veterinary: Medical: Science 2007, 69:1025-31.
19. Allergen nomenclature. http://www.allergen.org, International Union of Immunological Societies, Available at: Accessed 7 January 2008
20. Martin A, Sierra MP, Gonzalez JL. Identification of allergens responsible for canine cutaneous adverse food reactions to lamb, beef and cow's milk. Veterinary: Dermatology 2004, 15:349-56.
21. Ohmori K, Masuda K, Kawarai S. Identification of bovine serum albumin as an IgE-reactive beef component in a dog with food hypersensitivity against beef. The: Journal: of: Veterinary: Medical: Science 2007, 69:865-7.
22. Hays T, Wood RA. A systematic review of the role of hydrolyzed infant formulas in allergy prevention. Archives of Pediatrics and Adolescent Medicine 2005, 159:810-6.
23. Hill DJ, Murch SH, Rafferty K. The efficacy of amino acid-based formulas in relieving the symptoms of cow's milk allergy: a systematic review. Clinical: Experimental: Allergy 2007, 37:808-22.
24. Osborn DA, Sinn J. Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants. Cochrane Database of Systematic Reviews (Online) 2006, 4. http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD003664/pdf_fs.html, CD003664, Accessible at,
25. Ragno V, Giampietro PG, Bruno G. Allergenicity of milk protein hydrolysate formulae in children with cow's milk allergy. European: Journal: of: Pediatrics 1993, 152:760-2.
26. Giampietro PG, Kjellman NI, Oldaeus G. Hypoallergenicity of an extensively hydrolyzed whey formula. Pediatric: Allergy: Immunology 2001, 12:83-6.
27. Cave NJ. Hydrolyzed protein diets for dogs and cats. The Veterinary Clinics of North America. Small Animal Practice 2006, 36:1251-68.
28. Olson ME, Hardin JA, Buret AG. Hypersensitivity reactions to dietary antigens in atopic dogs. Recent Advances in Canine and Feline Nutrition 2000, 69-77. Reinhart GA, Carey DP, In, eds, III, Wilmington, OH, Orange Frazer Press
29. Puigdemont A, Brazis P, Serra M. Immunologic responses against hydrolyzed soy protein in dogs with experimentally induced soy hypersensitivity. American: Journal: of: Veterinary: Research 2006, 67:484-8.
30. Serra M, Brazis P, Fondati A. Assessment of IgE binding to native and hydrolyzed soy protein in serum obtained from dogs with experimentally induced soy protein hypersensitivity. American: Journal: of: Veterinary: Research 2006, 67:1895-900.
31. Ricci R, Jackson HA, Paps JS. The magnitude of the clinical response to oral proteins in dogs with spontaneous chicken allergy is significantly reduced when the protein is hydrolyzed (abstract). Veterinary: Dermatology 2006, 17:210.
32. Groh M, Moser E. Diagnosis of food allergy in the nonseasonally symptomatic dog using a novel antigen, low molecular weight diet: a prospective study of 29 cases. Journal of Veterinary Allergy and Clinical Immunology 1998, 6:5-6.
33. Sousa C, DeManuelle T, Power HT. Evaluation of the usefulness of purina CNM HA-formula in dogs with pruritic dermatosis that responds to a change in diet (Purina internal document). Nestlé Purina, St Louis, MO 2000, 1p.
34. Beale KM, Laflamme DP. Comparison of a hydrolyzed soy protein diet containing corn starch with a positive and negative control diet in corn- or soy-sensitive dogs (abstract). Veterinary: Dermatology 2001, 12:237.
35. Biourge BC, Fontaine J, Vroom MW. Diagnosis of adverse reactions to food in dogs: efficacy of a soy-isolate hydrolysate-based diet. Journal: of: Nutrition 2004, 134:2062S-4S.
36. Loeffler A, Lloyd DH, Bond R. Dietary trials with a commercial chicken hydrolysate diet in 63 pruritic dogs. Veterinary Record 2004, 154:519-22.
37. Loeffler A, Soares-Magalhaes R, Bond R. A retrospective analysis of case series using home-prepared and chicken hydrolysate diets in the diagnosis of adverse food reactions in 181 pruritic dogs. Veterinary: Dermatology 2006, 17:273-9.
38. Kennis RA, Tizard I, Hannah S. IgE antibodies to soy antigens, in sensitized and control dogs, detected by Western blot analysis and ELISA (abstract). Veterinary: Dermatology 2001, 12:232.
39. Kennis RA, Tizard I, Hannah S. Changes in IgE antibodies to soy in sensitized and control dogs after challenge using three diets in a crossover design (abstract). Veterinary: Dermatology 2002, 13:218.
40. Cave NJ, Guilford WG. In vivo assessment of antigenicity of a protein hydrolysate and characterization of a major antigen in chicken (abstract). Proceedings of the American College of Veterinary Internal Medicine (ACVIM) Forum 2000, In, Seattle, WA, ACVIM, 147A
41. Cave NJ, Guilford WG. A method for in vitro evaluation of protein hydrolysates for potential inclusion in veterinary diets. Research: in: Veterinary: Science 2004, 77:231-8.
42. Jüni P, Altman DG, Egger M. Systematic reviews in health care - assessing the quality of controlled clinical trials. British Medical Journal 2001, 323:42-6.
43. Rugo E, Wahl R, Wahn U. How allergenic are hypoallergenic infant formulae? Clinical: Experimental: Allergy 1992, 22:635-9.
44. Olivry T, Marsella R, Iwasaki T. Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis. Veterinary: Dermatology 2007, 18:79-96.
45. Hill PB, Lau P, Rybnicek J. Development of an owner-assessed scale to measure the severity of pruritus in dogs. Veterinary: Dermatology 2007, 18:301-8.