RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Sebastiani, Paola ^a   Montano, Monty ^b   Puca, Annibale ^c   Solovieff, Nadia ^a   Kojima, Toshio ^d   Wang, Meng C ^e   Melista, Efthymia ^b   Meltzer, Micah ^b   Fischer, Sylvia E J ^e   Andersen, Stacy ^b   Hartley, Stephen H ^a   Sedgewick, Amanda ^f   Arai, Yasumichi ^g   Bergman, Aviv ^h   Barzilai, Nir ^h   Terry, Dellara F ^b   Riva, Alberto ⁱ   Anselmi, Chiara Viviani ^c   Malovini, Alberto ^c   Kitamoto, Aya ^d   Sawabe, Motoji ^j   Arai, Tomio ^j   Gondo, Yasuyuki ^k   Steinberg, Martin H ^b   Hirose, Nobuyoshi ^g   Atzmon, Gil ^h   Ruvkun, Gary ^e   Baldwin, Clinton T ^b   Perls, Thomas T ^b   more..

^a BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c IRCCS MULTIMEDICA   (Italy)

^d RIKEN   (Japan)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f Boston University   (United States)

^g KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

ⁱ UNIVERSITY OF FLORIDA   (United States)

^j Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology   (Japan)

^k OSAKA UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE PROTEIN; CELL PROTEIN; GENE PRODUCT; PROTEIN ADARB1; PROTEIN ADARB2; PROTEIN ADR 1; PROTEIN ADR 2; PROTEIN RDE 1; UNCLASSIFIED DRUG; ADENOSINE DEAMINASE; DSRNA ADENOSINE DEAMINASE;

AGED; AGING; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC REGULATION; GENOTYPE; HEREDITY; HUMAN; JAPANESE; JEW; LIFESPAN; LINKAGE ANALYSIS; LONGEVITY; MALE; MUTATIONAL ANALYSIS; NONHUMAN; ORTHOLOGY; PROTEIN FUNCTION; RNA EDITING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL RATE; UNITED STATES; ADOLESCENT; ADULT; ALGORITHM; ANIMAL; CHROMOSOME 10; GENE; GENE FREQUENCY; GENETICS; MIDDLE AGED; REPRODUCIBILITY; RISK;

CAENORHABDITIS ELEGANS;

ADENOSINE DEAMINASE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; ANIMALS; CAENORHABDITIS ELEGANS; CHROMOSOMES, HUMAN, PAIR 10; FEMALE; GENE FREQUENCY; GENES, HELMINTH; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; LONGEVITY; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; RNA EDITING; YOUNG ADULT;

EID: 77949520652     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008210     Document Type: Article

References (51)

1. Christensen K, Johnson TE, Vaupel JW (2006) The quest for genetic determinants of human longevity: challenges and insights. Nat Rev Genet 7: 436-448.
2. Gudmundsson H, Gudbjartsson DF, Frigge M, Gulcher JR, Stefansson K (2000) Inheritance of human longevity in Iceland. Eur J Hum Genet 8: 743-749.
3. Hjelmborg JV, Iachine I, Skytthe A, Vaupel JW, McGue M, et al. (2006) Genetic influence on human lifespan and longevity. Hum Genet 119: 312-321.
4. Kerber RA, O'Brien E, Smith KR, Cawthon RM (2001) Familial excess longevity in Utah genealogies. J Gerontol A Biol Sci Med Sci 56: B130-139.
5. Perls T, Shea-Drinkwater M, Bowen-Flynn J, Ridge SB, Kang S, et al. (2000) Exceptional familial clustering for extreme longevity in humans. J Am Geriatr Soc 48: 1483-1485.
6. Perls TT, Wilmoth J, Levenson R, Drinkwater M, Cohen M, et al. (2002) Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci USA 99: 8442-8447.
7. Schoenmaker M, de Craen AJ, de Meijer PH, Beekman M, Blauw GJ, et al. (2006) Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. European Journal of Human Genetics 14: 79-84.
8. Terry DF, Wilcox MA, McCormick MA, Pennington JY, Schoenhofen EA, et al. (2004) Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring. J Am Geriatr Soc 52: 2074-2076.
9. Christensen K, McGue M, Petersen I, Jeune B, Vaupel JW (2008) Exceptional longevity does not result in excessive levels of disability. Proc Natl Acad Sci U S A 105: 13274-13279.
10. Hitt R, Young-Xu Y, Silver M, Perls T (1999) Centenarians: the older you get, the healthier you have been. Lancet 354: 652.
11. Terry DF, Sebastiani P, Andersen SL, Perls TT (2008) Disentangling the roles of disability and morbidity in survival to exceptional old age. Arch Intern Med 168: 277-283.
12. Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, et al. (2004) Clinical phenotype of families with longevity. J Am Geriatr Soc 52: 274-277.
13. Evert J, Lawler E, Bogan H, Perls T (2003) Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci 58: 232-237.
14. Schoenhofen EA, Wyszynski DF, Andersen S, Pennington J, Young R, et al. (2006) Characteristics of 32 supercentenarians. J Am Geriatr Soc 54: 1237-1240.
15. Finch CE, Tanzi RE (1997) Genetics of aging. Science 278: 407-411.
16. Salvioli S, Olivieri F, Marchegiani F, Cardelli M, Santoro A, et al. (2006) Genes, ageing and longevity in humans: problems, advantages and perspectives. Free Radic Res 40: 1303-1323.
17. Sorkin J, Post W, Pollin TI, O'Connell JR, Mitchell BD, et al. (2005) Exploring the genetics of longevity in the Old Order Amish. Mech Ageing Dev 126: 347-350.
18. Perls T (2001) Genetic and phenotypic markers among centenarians. J Gerontol A Biol Sci Med Sci 56: M67-70.
19. Perls T, Kunkel L, Puca A (2002) The genetics of aging. Curr Opin Genet Dev 12: 362-369.
20. Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, et al. (2003) Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 290: 2030-2040.
21. Atzmon G, Rincon M, Schechter CB, Shuldiner AR, Lipton RB, et al. (2006) Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol 4: e113.
22. Atzmon G, Pollin TI, Crandall J, Tanner K, Schechter CB, et al. (2008) Adiponectin levels and genotype: a potential regulator of life span in humans. J Gerontol A Biol Sci Med Sci 63: 447-453.
23. Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, et al. (2008) FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A 105: 13987-13992.
24. Flachsbart F, Caliebe A, Kleindorp R, Blanche H, von Eller-Eberstein H, et al. (2009) Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A 106: 2700-2705.
25. Vijg J, Campisi J (2008) Puzzles, promises and a cure for ageing. Nature 454: 1065-1071.
26. Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, et al. (2004) Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Exp Gerontol 39: 1595-1598.
27. Sebastiani P, Zhao Z, Abad-Grau MM, Riva A, Hartley SW, et al. (2008) A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples. BMC Genetics 9: 6.
28. Yang Q, Rasmussen SA, Friedman JM (2002) Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 359: 1019-1025.
29. Yang JH, Luo X, Nie Y, Su Y, Zhao Q, et al. (2003) Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation. Immunology 109: 15-23.
30. Finch CE, Morgan TE (2007) Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr Alzheimer Res 4: 185-189.
31. Maas S, Kawahara Y, Tamburro KM, Nishikura K (2006) A-to-I RNA editing and human disease. RNA Biol 3: 1-9.
32. Balding DJ (2006) A tutorial on statistical methods for population association studies. Nat Rev Genet 7: 781-791.
33. Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, et al. (1994) Genetic associations with human longevity at the APOE and ACE loci. Nat Genet 6: 29-32.
34. Vaupel JW, Carey JR, Christensen K, Johnson TE, Yashin AI, et al. (1998) Biodemographic trajectories of longevity. Science 280: 855-860.
35. Morse DP, Aruscavage PJ, Bass BL (2002) RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA. Proc Natl Acad Sci U S A 99: 7906-7911.
36. Tonkin LA, Saccomanno L, Morse DP, Brodigan T, Krause M, et al. (2002) RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans. EMBO J 21: 6025-6035.
37. Keegan LP, Brindle J, Gallo A, Leroy A, Reenan RA, et al. (2005) Tuning of RNA editing by ADAR is required in Drosophila. EMBO J 24: 2183-2193.
38. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
39. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, et al. (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292: 104-106.
40. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, et al. (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292: 107-110.
41. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, et al. (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421: 182-187.
42. Suh Y, Atzmon G, Cho M-O, Hwang D, Bingrong L, et al. (2008) Functionally significant insulin-like growth factor 1 receptor mutations in centenarians. Proc Natl Acad Sci U S A 105: 3438-3442.
43. Lee SS, Kennedy S, Tolonen AC, Ruvkun G (2003) DAF-16 target genes that control C. elegans life-span and metabolism. Science 300: 644-647.
44. Knight S, Bass B (2002) The role of RNA editing by ADARs in RNAi. Mol Cell Biol 10: 809-817.
45. Tonkin LA, Bass BL (2003) Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants. Science 302: 1725.
46. Lund J, Tedesco P, Duke K, Wang J, Kim SK, et al. (2002) Transcriptional profile of aging in C. elegans. Curr Biol 12: 1566-1573.
47. Wang D, Ruvkun G (2004) The insulin pathway regulates RNAi in C. elegans. Cold Spring Harbor Symposium on Quantitative Biology, 69th edition 69: 429-433.
48. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904-909.
49. Hinds DA, Stokowski RP, Patil N, Konvicka K, Kershenobich D, et al. (2004) Matching strategies for genetic association studies in structured populations. Am J Hum Genet 74: 317-325.
50. Spiegelhalter DJ, Myles JP, Jones DR, Abrams KR (1999) Methods in health service research. An introduction to bayesian methods in health technology assessment. BMJ 319: 508-512.
51. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.