Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure-activity relationship of the quinazoline ring

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2330-2334

  Sirisoma, Nilantha ^a   Pervin, Azra ^a   Zhang, Hong ^a   Jiang, Songchun ^a   Adam Willardsen, J ^b   Anderson, Mark B ^b   Mather, Gary ^b   Pleiman, Christopher M ^b   Kasibhatla, Shailaja ^a   Tseng, Ben ^a   Drewe, John ^a   Cai, Sui Xiong ^a  

^a EpiCept Corporation   (United States)

^b Myriad Pharmaceuticals   (United States)

Author keywords

Anticancer agents; Apoptosis inducers; SAR

Indexed keywords

1 (4 METHOXYANILINO) N METHYLISOQUINOLINE; 2 CHLORO N (4 METHOXYPHENYL) N METHYLQUINAZOLIN 4 AMINE; 2 METHYL 5 METHOXYQUINAZOLIN 4 OL; 4 (4 METHOXYANILINO) N METHYLQUINOLINE; 4 CHLORO 2 METHYLPYRIDO[2,3 D] PYRIMIDINE; 4 CHLORO 5 METHOXY 2 METHYLQUINAZOLINE; 4 CHLORO 6 NITRO 2 METHYLQUINAZOLINE; 4 CHLORO 7 NITRO 2 METHYLQUINAZOLINE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; AZIXA; CARBON; ISOQUINOLINE DERIVATIVE; N (4 METHOXYPHENYL) N,2 DIMETHYLQUINAZOLIN 4 AMINE; NITROGEN; QUINAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL LINE, TUMOR; FEMALE; HUMANS; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949486119     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.155     Document Type: Article

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