Hirsutenone inhibits lipopolysaccharide-activated NF-κB-induced inflammatory mediator production by suppressing Toll-like receptor 4 and ERK activation

International Immunopharmacology

Volumn 10, Issue 4, 2010, Pages 520-525

  Lee, Chung Soo ^a   Jang, Eun Ra ^a   Kim, Yun Jeong ^a   Lee, Min Sung ^b   Seo, Seong Jun ^c   Lee, Min Won ^a  

^a Chung Ang University   (South Korea)

^b Soonchunhyang University   (South Korea)

^c Chung Ang University College of Medicine   (South Korea)

Author keywords

ERK pathway; Hirsutenone; Inflammatory mediator production; Keratinocytes; Lipopolysaccharide; Toll like receptor 4

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; DEXAMETHASONE; ENDOTOXIN; HEPTANE DERIVATIVE; HIRSUTENONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INFLAMMATION; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN INFLAMMATION;

ALNUS; CATECHOLS; CELL NUCLEUS; CELLS, CULTURED; CHEMOKINE CCL17; CYTOSOL; DERMATITIS; DIARYLHEPTANOIDS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-18; INTERLEUKIN-1BETA; KERATINOCYTES; LIPOPOLYSACCHARIDES; NF-KAPPA B; SKIN; TOLL-LIKE RECEPTOR 4;

EID: 77949485775     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.01.015     Document Type: Article

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