IL-9 Induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Yamasaki, Akira ^a   Saleh, Ali ^a   Koussih, Latifa ^a   Muro, Shigeo ^b   Halayko, Andrew J ^a   Gounni, Abdelilah S ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EOTAXIN; INTERLEUKIN 9; PROTEIN STAT3 BETA; PROTEIN TYROSINE PHOSPHATASE SHP; STAT3 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; GENE SILENCING; HUMAN; IN VIVO STUDY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE FIBER; CELL CULTURE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; LUNG; METABOLISM; MUTATION; PHOSPHORYLATION; PROMOTER REGION; PROTEIN BINDING; PROTEIN TRANSPORT; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

CELL NUCLEUS; CELLS, CULTURED; CHEMOKINE CCL11; CHROMATIN IMMUNOPRECIPITATION; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-9; LUNG; MICROSCOPY, CONFOCAL; MUTATION; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN TRANSPORT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION;

EID: 77949478673     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009178     Document Type: Article

References (38)

1. Oliver BG, Black JL (2006) Airway smooth muscle and asthma. Allergol Int 55: 215-223.
2. Damera G, Tliba O, Panettieri RA Jr (2008) Airway smooth muscle as an immunomodulatory cell. Pulm Pharmacol Ther.
3. Demoulin JB, Renauld JC (1998) Interleukin 9 and its receptor: an overview of structure and function. Int Rev Immunol 16: 345-364.
4. Renauld JC (2001) New insights into the role of cytokines in asthma. J Clin Pathol 54: 577-589.
5. Soussi-Gounni A, Kontolemos M, Hamid Q (2001) Role of IL-9 in the pathophysiology of allergic diseases. J Allergy Clin Immunol 107: 575-582.
6. Ulbrecht M, Eisenhut T, Bonisch J, Kruse R, Wjst M, et al. (1997) High serum IgE concentrations: association with HLA-DR and markers on chromosome 5q31 and chromosome 11q13. J Allergy Clin Immunol 99: 828-836.
7. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, et al. (1995) Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 333: 894-900.
8. Temann UA, Geba GP, Rankin JA, Flavell RA (1998) Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 188: 1307-1320.
9. Temann UA, Ray P, Flavell RA (2002) Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. J Clin Invest 109: 29-39.
10. McLane MP, Haczku A, van de Rijn M, Weiss C, Ferrante V, et al. (1998) Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. Am J Respir Cell Mol Biol 19: 713-720.
11. Knoops L, Renauld JC (2004) IL-9 and its receptor: from signal transduction to tumorigenesis. Growth Factors 22: 207-215.
12. Demoulin JB, Uyttenhove C, Lejeune D, Mui A, Groner B, et al. (2000) STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells. Cancer Res 60: 3971-3977.
13. Demoulin JP, Grasso L, Atkins JM, Stevens M, Louahed J, et al. (2000) Role of insulin receptor substrate-2 in interleukin-9-dependent proliferation. FEBS Lett 482: 200-204.
14. Gounni AS, Hamid Q, Rahman SM, Hoeck J, Yang J, et al. (2004) IL-9-mediated induction of eotaxin1/CCL11 in human airway smooth muscle cells. J Immunol 173: 2771-2779.
15. Laporte JC, Moore PE, Baraldo S, Jouvin MH, Church TL, et al. (2001) Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells. Am J Respir Crit Care Med 164: 141-148.
16. Saleh A, Shan L, Halayko AJ, Kung S, Gounni AS (2009) Critical role for STAT3 in IL-17A-mediated CCL11 expression in human airway smooth muscle cells. J Immunol 182: 3357-3365.
17. Demoulin JB, Van Roost E, Stevens M, Groner B, Renauld JC (1999) Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. J Biol Chem 274: 25855-25861.
18. Demoulin JB, Uyttenhove C, Van Roost E, DeLestre B, Donckers D, et al. (1996) A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol 16: 4710-4716.
19. Rolling C, Treton D, Pellegrini S, Galanaud P, Richard Y (1996) IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells. FEBS Lett 393: 53-56.
20. Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP, et al. (1998) Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 18: 2545-2552.
21. Turkson J, Ryan D, Kim JS, Zhang Y, Chen Z, et al. (2001) Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 276: 45443-45455.
22. Wen Z, Darnell JE Jr (1997) Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res 25: 2062-2067.
23. Wen Z, Zhong Z, Darnell JE Jr (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
24. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, et al. (1996) Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med 2: 449-456.
25. Ghaffar O, Hamid Q, Renzi PM, Allakhverdi Z, Molet S, et al. (1999) Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells. Am J Respir Crit Care Med 159: 1933-1942.
26. Faffe DS, Flynt L, Mellema M, Moore PE, Silverman ES, et al. (2005) Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13. J Allergy Clin Immunol 115: 514-520.
27. Levy DE, Darnell JE Jr (2002) Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3: 651-662.
28. Kano A, Wolfgang MJ, Gao Q, Jacoby J, Chai GX, et al. (2003) Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med 198: 1517-1525.
29. El Kasmi KC, Holst J, Coffre M, Mielke L, de Pauw A, et al. (2006) General nature of the STAT3-activated anti-inflammatory response. J Immunol 177: 7880-7888.
30. Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, et al. (2007) Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma. J Immunol 178: 6191-6199.
31. Shen Y, Schlessinger K, Zhu X, Meffre E, Quimby F, et al. (2004) Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation. Mol Cell Biol 24: 407-419.
32. Acacia de Sa Pinheiro A, Morrot A, Chakravarty S, Overstreet M, Bream JH, et al. (2007) IL-4 induces a wide-spectrum intracellular signaling cascade in CD8+ T cells. J Leukoc Biol 81: 1102-1110.
33. Baraldo S, Faffe DS, Moore PE, Whitehead T, McKenna M, et al. (2003) Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK. Am J Physiol Lung Cell Mol Physiol 284: L1093-1102.
34. Chung J, Uchida E, Grammer TC, Blenis J (1997) STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 17: 6508-6516.
35. Lim CP, Cao X (1999) Serine phosphorylation and negative regulation of Stat3 by JNK. J Biol Chem 274: 31055-31061.
36. Hamann KJ, Vieira JE, Halayko AJ, Dorscheid D, White SR, et al. (2000) Fas cross-linking induces apoptosis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 278: L618-624.
37. Bindra RS, Gibson SL, Meng A, Westermark U, Jasin M, et al. (2005) Hypoxiainduced down-regulation of BRCA1 expression by E2Fs. Cancer Res 65: 11597-11604.
38. Kung SK, An DS, Chen IS (2000) A murine leukemia virus (MuLV) long terminal repeat derived from rhesus macaques in the context of a lentivirus vector and MuLV gag sequence results in high-level gene expression in human T lymphocytes. J Virol 74: 3668-3681.