메뉴 건너뛰기




Volumn 21, Issue 6, 2010, Pages 936-945

A receptor-associated protein/phosphatidylinositol 3-kinase pathway controls pseudopod formation

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN GBPD; RAP1 PROTEIN; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYBRID PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; PROTOZOAL PROTEIN; RAS PROTEIN; RASG PROTEIN, DICTYOSTELIUM;

EID: 77949457532     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E09-03-0177     Document Type: Article
Times cited : (39)

References (63)
  • 1
    • 0032499260 scopus 로고    scopus 로고
    • Chemokines and leukocyte traffic
    • Baggiolini, M. (1998). Chemokines and leukocyte traffic. Nature 392, 565-568.
    • (1998) Nature , vol.392 , pp. 565-568
    • Baggiolini, M.1
  • 2
    • 0842266583 scopus 로고    scopus 로고
    • Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion
    • Bivona, T. G., Wiener, H. H., Ahearn, I. M., Silletti, J., Chiu, V. K., and Philips, M. R. (2004). Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J. Cell Biol. 164, 461-470.
    • (2004) J. Cell Biol , vol.164 , pp. 461-470
    • Bivona, T.G.1    Wiener, H.H.2    Ahearn, I.M.3    Silletti, J.4    Chiu, V.K.5    Philips, M.R.6
  • 3
    • 33749472179 scopus 로고    scopus 로고
    • Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum
    • Bolourani, P., Spiegelman, G. B., and Weeks, G. (2006). Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum. Mol. Biol. Cell 17, 4543-4550.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 4543-4550
    • Bolourani, P.1    Spiegelman, G.B.2    Weeks, G.3
  • 4
    • 44349156489 scopus 로고    scopus 로고
    • Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation
    • Bolourani, P., Spiegelman, G. B., and Weeks, G. (2008). Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation. J. Biol. Chem. 283, 10232-10240.
    • (2008) J. Biol. Chem , vol.283 , pp. 10232-10240
    • Bolourani, P.1    Spiegelman, G.B.2    Weeks, G.3
  • 5
    • 15044359236 scopus 로고    scopus 로고
    • Linking Rap to cell adhesion
    • Bos, J. L. (2005). Linking Rap to cell adhesion. Curr. Opin. Cell Biol. 17, 123-128.
    • (2005) Curr. Opin. Cell Biol , vol.17 , pp. 123-128
    • Bos, J.L.1
  • 7
    • 0037009436 scopus 로고    scopus 로고
    • A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium
    • Bosgraaf, L., Russcher, H., Smith, J. L., Wessels, D., Soll, D. R., and Van Haastert, P.J.M. (2002). A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium. EMBO J. 21, 4560-4570.
    • (2002) EMBO J , vol.21 , pp. 4560-4570
    • Bosgraaf, L.1    Russcher, H.2    Smith, J.L.3    Wessels, D.4    Soll, D.R.5    Van Haastert, P.J.M.6
  • 8
    • 19444363399 scopus 로고    scopus 로고
    • RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium
    • Bosgraaf, L., Waijer, A., Engel, R., Visser, A. J., Wessels, G., Soll, D., and Van Haastert, P. J. (2005). RasGEF-containing proteins GbpC and GbpD have differential effects on cell polarity and chemotaxis in Dictyostelium. J. Cell Sci. 118, 1899-1910.
    • (2005) J. Cell Sci , vol.118 , pp. 1899-1910
    • Bosgraaf, L.1    Waijer, A.2    Engel, R.3    Visser, A.J.4    Wessels, G.5    Soll, D.6    Van Haastert, P.J.7
  • 9
    • 0026026818 scopus 로고
    • The Gtpase superfamily - conserved structure and molecular mechanism
    • Bourne, H. R., Sanders, D. A., and McCormick, F. (1991). The Gtpase superfamily - conserved structure and molecular mechanism. Nature 349, 117-127.
    • (1991) Nature , vol.349 , pp. 117-127
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 10
    • 0034054496 scopus 로고    scopus 로고
    • Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
    • Campbell, J. J., and Butcher, E. C. (2000). Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 12, 336-341.
    • (2000) Curr. Opin. Immunol , vol.12 , pp. 336-341
    • Campbell, J.J.1    Butcher, E.C.2
  • 12
    • 0142211303 scopus 로고    scopus 로고
    • Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation
    • Christian, S. L., Lee, R. L., Mcleod, S. J., Burgess, A. E., Li, A.H.Y., Dang-Lawson, M., Lin, K.B.L., and Gold, M. R. (2003). Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. J. Biol. Chem. 278, 41756-41767.
    • (2003) J. Biol. Chem , vol.278 , pp. 41756-41767
    • Christian, S.L.1    Lee, R.L.2    Mcleod, S.J.3    Burgess, A.E.4    Li, A.H.Y.5    Dang-Lawson, M.6    Lin, K.B.L.7    Gold, M.R.8
  • 13
    • 0035869233 scopus 로고    scopus 로고
    • Dictyostelium: An ideal organism for genetic dissection of Ras signalling networks
    • Chubb, J. R., and Insall, R. H. (2001). Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks. Biochim. Biophys. Acta 1525, 262-271.
    • (2001) Biochim. Biophys. Acta , vol.1525 , pp. 262-271
    • Chubb, J.R.1    Insall, R.H.2
  • 14
    • 0037168119 scopus 로고    scopus 로고
    • The bound leading the bound: Targetderived receptors act as guidance cues
    • Crone, S. A., and Lee, K. F. (2002). The bound leading the bound: targetderived receptors act as guidance cues. Neuron 36, 333-335.
    • (2002) Neuron , vol.36 , pp. 333-335
    • Crone, S.A.1    Lee, K.F.2
  • 15
    • 0024147085 scopus 로고
    • Chemotaxis in eukaryotic cells - a focus on leukocytes and Dictyostelium
    • Devreotes, P. N., and Zigmond, S. H. (1988). Chemotaxis in eukaryotic cells - a focus on leukocytes and Dictyostelium. Annu. Rev. Cell Biol. 4, 649-686.
    • (1988) Annu. Rev. Cell Biol , vol.4 , pp. 649-686
    • Devreotes, P.N.1    Zigmond, S.H.2
  • 16
    • 18344395923 scopus 로고    scopus 로고
    • Eichinger, L., Pachebat, J. A., Glockner, G., Rajandream, M. A., Sucgang, R., Berriman, M., Song, J., Olsen, R., Szafranski, K., Xu, et al, Q. (2005). The genome of the social amoeba Dictyostelium discoideum. Nature 435, 43-57.
    • Eichinger, L., Pachebat, J. A., Glockner, G., Rajandream, M. A., Sucgang, R., Berriman, M., Song, J., Olsen, R., Szafranski, K., Xu, et al, Q. (2005). The genome of the social amoeba Dictyostelium discoideum. Nature 435, 43-57.
  • 17
    • 0037164750 scopus 로고    scopus 로고
    • SadA, a novel adhesion receptor in Dictyostelium
    • Fey, P., Stephens, S., Titus, M. A., and Chisholm, R. L. (2002). SadA, a novel adhesion receptor in Dictyostelium. J. Cell Biol. 159, 1109-1119.
    • (2002) J. Cell Biol , vol.159 , pp. 1109-1119
    • Fey, P.1    Stephens, S.2    Titus, M.A.3    Chisholm, R.L.4
  • 18
    • 0037205265 scopus 로고    scopus 로고
    • Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
    • Funamoto, S., Meili, R., Lee, S., Parry, L., and Firtel, R. A. (2002). Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623.
    • (2002) Cell , vol.109 , pp. 611-623
    • Funamoto, S.1    Meili, R.2    Lee, S.3    Parry, L.4    Firtel, R.A.5
  • 19
    • 0035858886 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
    • Funamoto, S., Milan, K., Meili, R., and Firtel, R. A. (2001). Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J. Cell Biol. 153, 795-809.
    • (2001) J. Cell Biol , vol.153 , pp. 795-809
    • Funamoto, S.1    Milan, K.2    Meili, R.3    Firtel, R.A.4
  • 21
    • 0037308836 scopus 로고    scopus 로고
    • Ras-effector interactions: After one decade
    • Herrmann, C. (2003). Ras-effector interactions: after one decade. Curr. Opin. Struct. Biol. 13, 122-129.
    • (2003) Curr. Opin. Struct. Biol , vol.13 , pp. 122-129
    • Herrmann, C.1
  • 22
    • 0029913467 scopus 로고    scopus 로고
    • Differential interaction of the Ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor
    • Herrmann, C., Horn, G., Spaargaren, M., and Wittinghofer, A. (1996). Differential interaction of the Ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J. Biol. Chem. 271, 6794-6800.
    • (1996) J. Biol. Chem , vol.271 , pp. 6794-6800
    • Herrmann, C.1    Horn, G.2    Spaargaren, M.3    Wittinghofer, A.4
  • 23
    • 34247361650 scopus 로고    scopus 로고
    • Chemotaxis in the absence of PIP3 gradients
    • Hoeller, O., and Kay, R. R. (2007). Chemotaxis in the absence of PIP3 gradients. Curr. Biol. 17, 813-817.
    • (2007) Curr. Biol , vol.17 , pp. 813-817
    • Hoeller, O.1    Kay, R.R.2
  • 24
    • 0038247883 scopus 로고    scopus 로고
    • Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P-3 to the leading edge of chemotaxing cells
    • Huang, Y. E., Iijima, M., Parent, C. A., Funamoto, S., Firtel, R. A., and Devreotes, P. (2003). Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P-3 to the leading edge of chemotaxing cells. Mol. Biol. Cell 14, 1913-1922.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1913-1922
    • Huang, Y.E.1    Iijima, M.2    Parent, C.A.3    Funamoto, S.4    Firtel, R.A.5    Devreotes, P.6
  • 25
    • 0036773899 scopus 로고    scopus 로고
    • Temporal and spatial regulation of chemotaxis
    • Iijima, M., Huang, Y. E., and Devreotes, P. (2002). Temporal and spatial regulation of chemotaxis. Dev. Cell 3, 469-478.
    • (2002) Dev. Cell , vol.3 , pp. 469-478
    • Iijima, M.1    Huang, Y.E.2    Devreotes, P.3
  • 26
    • 16244377763 scopus 로고    scopus 로고
    • Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis
    • Janetopoulos, C., Borleis, J., Vazquez, F., Iijima, M., and Devreotes, P. (2005). Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev. Cell 8, 467-477.
    • (2005) Dev. Cell , vol.8 , pp. 467-477
    • Janetopoulos, C.1    Borleis, J.2    Vazquez, F.3    Iijima, M.4    Devreotes, P.5
  • 27
    • 36849005496 scopus 로고    scopus 로고
    • Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells
    • Jeon, T. J., Lee, D. J., Lee, S., Weeks, G., and Firtel, R. A. (2007a). Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells. J. Cell Biol. 179, 833-843.
    • (2007) J. Cell Biol , vol.179 , pp. 833-843
    • Jeon, T.J.1    Lee, D.J.2    Lee, S.3    Weeks, G.4    Firtel, R.A.5
  • 28
    • 33947718091 scopus 로고    scopus 로고
    • Rap1 controls cell adhesion and cell motility through the regulation of myosin II
    • Jeon, T. J., Lee, D. J., Merlot, S., Weeks, G., and Firtel, R. A. (2007b). Rap1 controls cell adhesion and cell motility through the regulation of myosin II. J. Cell Biol. 176, 1021-1033.
    • (2007) J. Cell Biol , vol.176 , pp. 1021-1033
    • Jeon, T.J.1    Lee, D.J.2    Merlot, S.3    Weeks, G.4    Firtel, R.A.5
  • 30
    • 4344571626 scopus 로고    scopus 로고
    • Kae, H., Lim, C. J., Spiegelman, G. B., and Weeks, G. (2004). Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep. 5, 602-606.
    • Kae, H., Lim, C. J., Spiegelman, G. B., and Weeks, G. (2004). Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep. 5, 602-606.
  • 31
    • 47049110588 scopus 로고    scopus 로고
    • PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis
    • Kamimura, Y., Xiong, Y., Iglesias, P. A., Hoeller, O., Bolourani, P., and Devreotes, P. N. (2008). PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Biol. 18, 1034-1043.
    • (2008) Curr. Biol , vol.18 , pp. 1034-1043
    • Kamimura, Y.1    Xiong, Y.2    Iglesias, P.A.3    Hoeller, O.4    Bolourani, P.5    Devreotes, P.N.6
  • 32
    • 0037106068 scopus 로고    scopus 로고
    • Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress
    • Kang, R. J., Kae, H., Ip, H., Spiegelman, G. B., and Weeks, G. (2002). Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress. J. Cell Sci. 115, 3675-3682.
    • (2002) J. Cell Sci , vol.115 , pp. 3675-3682
    • Kang, R.J.1    Kae, H.2    Ip, H.3    Spiegelman, G.B.4    Weeks, G.5
  • 33
    • 0029892973 scopus 로고    scopus 로고
    • Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development
    • Khosla, M., Spiegelman, G. B., and Weeks, G. (1996). Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development. Mol. Cell. Biol. 16, 4156-4162.
    • (1996) Mol. Cell. Biol , vol.16 , pp. 4156-4162
    • Khosla, M.1    Spiegelman, G.B.2    Weeks, G.3
  • 34
    • 37049035944 scopus 로고    scopus 로고
    • Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis
    • Kortholt, A., King, J. S., Keizer-Gunnink, I., Harwood, A. J., and Van Haastert, P. J. (2007). Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis. Mol. Biol. Cell 18, 4772-4779.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 4772-4779
    • Kortholt, A.1    King, J.S.2    Keizer-Gunnink, I.3    Harwood, A.J.4    Van Haastert, P.J.5
  • 36
    • 45449120580 scopus 로고    scopus 로고
    • Highlighting the role of Ras and Rap during Dictyostelium chemotaxis
    • Kortholt, A. and Van Haastert, P. J. (2008). Highlighting the role of Ras and Rap during Dictyostelium chemotaxis. Cell Signal. 20, 1415-1422.
    • (2008) Cell Signal , vol.20 , pp. 1415-1422
    • Kortholt, A.1    Van Haastert, P.J.2
  • 37
    • 0035881962 scopus 로고    scopus 로고
    • RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation
    • Lim, C. J., Spiegelman, G. B., and Weeks, G. (2001). RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation. EMBO J. 20, 4490-4499.
    • (2001) EMBO J , vol.20 , pp. 4490-4499
    • Lim, C.J.1    Spiegelman, G.B.2    Weeks, G.3
  • 38
    • 18844443195 scopus 로고    scopus 로고
    • Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis
    • Lim, C. J., Zawadzki, K. A., Khosla, M., Secko, D. M., Spiegelman, G. B., and Weeks, G. (2005). Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis. Exp. Cell Res. 306, 47-55.
    • (2005) Exp. Cell Res , vol.306 , pp. 47-55
    • Lim, C.J.1    Zawadzki, K.A.2    Khosla, M.3    Secko, D.M.4    Spiegelman, G.B.5    Weeks, G.6
  • 39
    • 33745384269 scopus 로고    scopus 로고
    • Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: A quantitative in vivo analysis by inhibition of PI3-kinase
    • Loovers, H. M., Postma, M., Keizer-Gunnink, I., Huang, Y. E., Devreotes, P. N., and Van Haastert, P. J. (2006). Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol. Biol. Cell 17, 1503-1513.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 1503-1513
    • Loovers, H.M.1    Postma, M.2    Keizer-Gunnink, I.3    Huang, Y.E.4    Devreotes, P.N.5    Van Haastert, P.J.6
  • 40
    • 0037031872 scopus 로고    scopus 로고
    • cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b
    • Lou, L. G., Urbani, J., Ribeiro-Neto, F., and Altschuler, D. L. (2002). cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. J. Biol. Chem. 277, 32799-32806.
    • (2002) J. Biol. Chem , vol.277 , pp. 32799-32806
    • Lou, L.G.1    Urbani, J.2    Ribeiro-Neto, F.3    Altschuler, D.L.4
  • 41
    • 0037192820 scopus 로고    scopus 로고
    • Differential signaling of cyclic AMP - opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation
    • Mei, F. C., Qiao, J. B., Tsygankova, O. M., Meinkoth, J. L., Quilliam, L. A., and Cheng, X. D. (2002). Differential signaling of cyclic AMP - opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J. Biol. Chem. 277, 11497-11504.
    • (2002) J. Biol. Chem , vol.277 , pp. 11497-11504
    • Mei, F.C.1    Qiao, J.B.2    Tsygankova, O.M.3    Meinkoth, J.L.4    Quilliam, L.A.5    Cheng, X.D.6
  • 42
    • 0033560747 scopus 로고    scopus 로고
    • Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
    • Meili, R., Ellsworth, C., Lee, S., Reddy, T. B., Ma, H., and Firtel, R. A. (1999). Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18, 2092-2105.
    • (1999) EMBO J , vol.18 , pp. 2092-2105
    • Meili, R.1    Ellsworth, C.2    Lee, S.3    Reddy, T.B.4    Ma, H.5    Firtel, R.A.6
  • 43
    • 0032475863 scopus 로고    scopus 로고
    • G protein signaling events are activated at the leading edge of chemotactic cells
    • Parent, C. A., Blacklock, B. J., Froehlich, W. M., Murphy, D. B., and Devreotes, P. N. (1998). G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95, 81-91.
    • (1998) Cell , vol.95 , pp. 81-91
    • Parent, C.A.1    Blacklock, B.J.2    Froehlich, W.M.3    Murphy, D.B.4    Devreotes, P.N.5
  • 44
    • 63349091530 scopus 로고    scopus 로고
    • Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium
    • Parkinson, K., Bolourani, P., Traynor, D., Aldren, N. L., Kay, R. R., Weeks, G., and Thompson, C. R. (2009). Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium. J. Cell Sci. 122, 335-344.
    • (2009) J. Cell Sci , vol.122 , pp. 335-344
    • Parkinson, K.1    Bolourani, P.2    Traynor, D.3    Aldren, N.L.4    Kay, R.R.5    Weeks, G.6    Thompson, C.R.7
  • 45
    • 0027436004 scopus 로고
    • Altered morphology of vegetative amoebae induced by increased expression of the Dictyostelium discoideum ras-related gene rap1
    • Rebstein, P. J., Weeks, G., and Spiegelman, G. B. (1993). Altered morphology of vegetative amoebae induced by increased expression of the Dictyostelium discoideum ras-related gene rap1. Dev. Genet. 14, 347-355.
    • (1993) Dev. Genet , vol.14 , pp. 347-355
    • Rebstein, P.J.1    Weeks, G.2    Spiegelman, G.B.3
  • 46
    • 33748376922 scopus 로고    scopus 로고
    • Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR
    • Sasaki, A. T., and Firtel, R. A. (2006). Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur. J. Cell Biol. 85, 873-895.
    • (2006) Eur. J. Cell Biol , vol.85 , pp. 873-895
    • Sasaki, A.T.1    Firtel, R.A.2
  • 48
    • 4344594485 scopus 로고    scopus 로고
    • The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity
    • Schwamborn, J. C., and Puschel, A. W. (2004). The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat. Neurosci. 7, 923-929.
    • (2004) Nat. Neurosci , vol.7 , pp. 923-929
    • Schwamborn, J.C.1    Puschel, A.W.2
  • 49
    • 0032587546 scopus 로고    scopus 로고
    • The small M-r Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum
    • Seastone, D. J., Zhang, L. Y., Buczynski, G., Rebstein, P., Weeks, G., Spiegelman, G., and Cardelli, J. (1999). The small M-r Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum. Mol. Biol. Cell 10, 393-406.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 393-406
    • Seastone, D.J.1    Zhang, L.Y.2    Buczynski, G.3    Rebstein, P.4    Weeks, G.5    Spiegelman, G.6    Cardelli, J.7
  • 50
    • 0037428076 scopus 로고    scopus 로고
    • Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity
    • Shi, S. H., Jan, L. Y., and Jan, Y. N. (2003). Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell 112, 63-75.
    • (2003) Cell , vol.112 , pp. 63-75
    • Shi, S.H.1    Jan, L.Y.2    Jan, Y.N.3
  • 51
    • 0032933749 scopus 로고    scopus 로고
    • Computer-assisted three-dimensional reconstruction and motion analysis of living, crawling cells
    • Soll, D. R. (1999). Computer-assisted three-dimensional reconstruction and motion analysis of living, crawling cells. Comput. Med. Imaging Graphics 23, 3-14.
    • (1999) Comput. Med. Imaging Graphics , vol.23 , pp. 3-14
    • Soll, D.R.1
  • 52
    • 34247372469 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium
    • Takeda, K., Sasaki, A. T., Ha, H. J., Seung, H. A., and Firtel, R. A. (2007). Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium. J. Biol. Chem. 282, 11874-11884.
    • (2007) J. Biol. Chem , vol.282 , pp. 11874-11884
    • Takeda, K.1    Sasaki, A.T.2    Ha, H.J.3    Seung, H.A.4    Firtel, R.A.5
  • 53
    • 0035016611 scopus 로고    scopus 로고
    • Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A
    • Tsygankova, O. M., Saavedra, A., Rebhun, J. F., Quilliam, L. A., and Meinkoth, J. L. (2001). Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Mol. Cell. Biol. 21, 1921-1929.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 1921-1929
    • Tsygankova, O.M.1    Saavedra, A.2    Rebhun, J.F.3    Quilliam, L.A.4    Meinkoth, J.L.5
  • 55
    • 34249873508 scopus 로고    scopus 로고
    • Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis
    • Van Haastert, P. J., Keizer-Gunnink, I., and Kortholt, A. (2007). Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. J. Cell Biol. 177, 809-816.
    • (2007) J. Cell Biol , vol.177 , pp. 809-816
    • Van Haastert, P.J.1    Keizer-Gunnink, I.2    Kortholt, A.3
  • 57
    • 58849149327 scopus 로고    scopus 로고
    • A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum
    • Veltman, D. M., Akar, G., Bosgraaf, L., and Van Haastert, P. J. (2009a). A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum. Plasmid 61, 110-118.
    • (2009) Plasmid , vol.61 , pp. 110-118
    • Veltman, D.M.1    Akar, G.2    Bosgraaf, L.3    Van Haastert, P.J.4
  • 58
    • 40849116525 scopus 로고    scopus 로고
    • Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum
    • Veltman, D. M., Keizer-Gunnik, I., and Van Haastert, P. J. (2008). Four key signaling pathways mediating chemotaxis in Dictyostelium discoideum. J. Cell Biol. 180, 747-753.
    • (2008) J. Cell Biol , vol.180 , pp. 747-753
    • Veltman, D.M.1    Keizer-Gunnik, I.2    Van Haastert, P.J.3
  • 59
    • 58849112548 scopus 로고    scopus 로고
    • An extrachromosomal, inducible expression system for Dictyostelium discoideum
    • Veltman, D. M., Keizer-Gunnink, I., and Haastert, P. J. (2009b). An extrachromosomal, inducible expression system for Dictyostelium discoideum. Plasmid 61, 119-125.
    • (2009) Plasmid , vol.61 , pp. 119-125
    • Veltman, D.M.1    Keizer-Gunnink, I.2    Haastert, P.J.3
  • 60
    • 77949457892 scopus 로고    scopus 로고
    • Weeks, G. (2005). The small GTPase superfamily. In: Dictyostelium Genomics, ed. Wiliam F. Loomis and Adam Kuspa, Norwich, United Kingdom: Horizon Bioscience, 173-210.
    • Weeks, G. (2005). The small GTPase superfamily. In: Dictyostelium Genomics, ed. Wiliam F. Loomis and Adam Kuspa, Norwich, United Kingdom: Horizon Bioscience, 173-210.
  • 61
    • 0035061264 scopus 로고    scopus 로고
    • Small GTPases in Dictyostelium: Lessons from a social amoeba
    • Wilkins, A., and Insall, R. H. (2001). Small GTPases in Dictyostelium: lessons from a social amoeba. Trends Genet. 17, 41-48.
    • (2001) Trends Genet , vol.17 , pp. 41-48
    • Wilkins, A.1    Insall, R.H.2
  • 63
    • 0031906278 scopus 로고    scopus 로고
    • Disruption of Dictyostelium P13K genes reduces [P-32]phosphatidylinositol 3,4 bisphosphate and [P-32]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis
    • Zhou, K. M., Pandol, S., Bokoch, G., and Traynor-Kaplan, A. E. (1998). Disruption of Dictyostelium P13K genes reduces [P-32]phosphatidylinositol 3,4 bisphosphate and [P-32]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis. J. Cell Sci. 111, 283-294.
    • (1998) J. Cell Sci , vol.111 , pp. 283-294
    • Zhou, K.M.1    Pandol, S.2    Bokoch, G.3    Traynor-Kaplan, A.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.