Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis

Experimental Cell Research

Volumn 306, Issue 1, 2005, Pages 47-55

  Lim, Chinten James ^a,b   Zawadzki, Karl A ^a,c   Khosla, Meenal ^a   Secko, David M ^a   Spiegelman, George B ^a   Weeks, Gerald ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c PRINCETON UNIVERSITY   (United States)

Author keywords

Akt PKB; Cell size; Cytoskeleton; Endocytosis; ERK2; Folate; Motility; Ras

Indexed keywords

CYCLIC AMP; F ACTIN; FOLIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL FUNCTION; CELL MOTILITY; CELL SIZE; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINESIS; DICTYOSTELIUM DISCOIDEUM; ENDOCYTOSIS; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WILD TYPE;

DICTYOSTELIUM;

EID: 18844443195     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2005.02.002     Document Type: Article

References (32)

1. H.R. Bourne, D.A. Sanders, and F. McCormick The GTPase superfamily: conserved structure and molecular mechanism Nature 349 1991 117 127
2. S.L. Campbell, R. Khosravi-Far, K.L. Rossman, G.J. Clark, and C.J. Der Increasing complexity of Ras signaling Oncogene 17 1998 1395 1413
3. G.W. Reuther, and C.J. Der The Ras branch of GTPases: Ras family members don't fall far from the tree Curr. Opin. Cell Biol. 12 2000 157 165
4. A. Wilkins, and R.H. Insall Small GTPases in Dictyostelium: lessons from a social amoeba Trends Genet. 17 2001 41 48
5. J. Daniel, G.B. Spiegelman, and G. Weeks Dictyostelium ras genes M. Zerial L.A. Huber Guidebook to the small GTPases 1995 Oxford University Press NY
6. C.D. Reymond, R.H. Gomer, M.C. Mehdy, and R.A. Firtel Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian Ras protein Cell 39 1984 141 148
7. J.R. Chubb, A. Wilkins, G.M. Thomas, and R.H. Insall The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement J. Cell Sci. 113 2000 709 719
8. A. Wilkins, M. Khosla, D.J. Fraser, G.B. Spiegelman, P.R. Fisher, G. Weeks, and R.H. Insall Dictyostelium RasD is required for normal phototaxis, but not differentiation Genes Dev. 14 2000 1407 1413
9. R.I. Tuxworth, J.L. Cheetham, L.M. Machesky, G.B. Spiegelman, G. Weeks, and R.H. Insall Dictyostelium RasG is required for normal motility and cytokinesis, but not growth J. Cell Biol. 138 1997 605 614
10. B.W. Sutherland, G.B. Spiegelman, and G. Weeks A Ras subfamily GTPase shows cell cycle-dependent nuclear localization EMBO Rep. 2 2001 1024 1028
11. R. Kang, H. Kae, H. Ip, G.B. Spiegelman, and G. Weeks Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress J. Cell Sci. 115 2002 3675 3682
12. C.J. Lim, G.B. Spiegelman, and G. Weeks RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation EMBO J. 20 2001 4490 4499
13. D. Wessels, R. Brincks, S. Kuhl, V. Stepanovic, K.J. Daniels, G. Weeks, C.J. Lim, G. Spiegelman, D. Fuller, N. Iranfar, W.F. Loomis, and D.R. Soll RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum Eukaryotic Cell 3 2004 646 662
14. D.J. Watts, and J.M. Ashworth Growth of myxamoebae of the cellular slime mould Dictyostelium discoideum in axenic culture Biochem. J. 119 1970 171 174
15. S.J. Palmieri, T. Nebl, R.K. Pope, D.J. Seastone, E. Lee, E.H. Hinchcliffe, G. Sluder, D. Knecht, J. Cardelli, and E.J. Luna Mutant Rac1B expression in Dictyostelium: effects on morphology, growth, endocytosis, development, and the actin cytoskeleton Cell Motil. Cytoskeleton 46 2000 285 304
16. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning. A laboratory manual second ed. 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor
17. J.H. Blusch, and W. Nellen Folate responsiveness during growth and development of Dictyostelium-separate but related pathways control chemotaxis and gene regulation Mol. Microbiol. 11 1994 331 335
18. Y.H. Han, C.Y. Chung, D. Wessels, S. Stephens, M.A. Titus, D.R. Soll, and R.A. Firtel Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in Dictyostelium J. Biol. Chem. 277 2002 49877 49887
19. J.L. Rifkin, and R.A. Speisman Filamentous extensions of vegetative amoebae of the cellular slime mold Dictyostelium Trans. Am. Microsc. Soc. 95 1976 165 173
20. J.V. Small, T. Stradal, E. Vignal, and K. Rottner The lamellipodium: where motility begins Trends Cell Biol. 12 2002 112 120
21. A.J. Koleske Do filopodia enable the growth cone to find its way? Sci. Signal Transduct. Knowl. Environ. 2003 e20
22. M. Maeda, and R.A. Firtel Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in Dictyostelium J. Biol. Chem. 272 1997 23690 23695
23. Y. Wang, J. Liu, and J.E. Segall MAP kinase function in amoeboid chemotaxis J. Cell Sci. 111 1998 373 383
24. R. Meili, C. Ellsworth, S. Lee, T.B.K. Reddy, H. Ma, and R.A. Firtel Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium EMBO J. 18 1999 2092 2105
25. M. Dumontier, P. Hocht, U. Mintert, and J. Faix Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium J. Cell Sci. 113 2000 2253 2265
26. J. Cardelli Phagocytosis and macropinocytosis in Dictyostelium: phosphoinositide-based processes, biochemically distinct Traffic 2 2001 311 320
27. C.J. Lim, G.B. Spiegelman, and G. Weeks Cytoskeletal regulation by Dictyostelium Ras subfamily proteins J. Muscle Res. Cell Motil. 23 2002 729 736
28. D.J. Seastone, E. Lee, J. Bush, D. Knecht, and J. Cardelli Overexpression of a novel rho family GTPase, RacC, induces unusual actin-based structures and positively affects phagocytosis in Dictyostelium discoideum. Mol. Biol. Cell 9 1998 2891 2904
29. D.J. Seastone, L.Y. Zhang, G. Buczynski, P. Rebstein, G. Weeks, G. Spiegelman, and J. Cardelli The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum Mol. Biol. Cell 10 1999 393 406
30. B.D. Manning, and L.C. Cantley Rheb fills a GAP between TSC and TOR Trends Biochem. Sci. 28 2003 573 576
31. L.J. Saucedo, and B.A. Edgar Why size matters: altering cell size Curr. Opin. Genet. Dev. 12 2002 565 571
32. P.H. Patel, N. Thapar, L. Guo, M. Martinez, J. Maris, C. Gau, J.A. Lengyel, and F. Tamanoi Drosophila Rheb GTPase is required for cell cycle progression and cell growth J. Cell Sci. 116 2003 3601 3610