Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins

Human Molecular Genetics

Volumn 19, Issue 2, 2009, Pages 262-275

  del Castillo, Francisco J ^a,b,c,d   Cohen Salmon, Martine ^a,b,e,j   Charollais, Anne ^f   Caille, Dorothée ^f   Lampe, Paul D ^g   Chavrier, Philippe ^h,i   Meda, Paolo ^f   Petit, Christine ^a,b,e,j  

^a INSTITUT PASTEUR   (France)

^b Institut Pasteur   (France)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e SORBONNE UNIVERSITÉ   (France)

^f UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^g Fred Hutchinson Cancer Research Center   (United States)

^h INSTITUT CURIE   (France)

ⁱ CNRS   (France)

^j Paris Sciences et Lettres   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CONSORTIN; MEMBRANE PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CARRIER PROTEIN; CONSORTIN PROTEIN, HUMAN; CONSORTIN PROTEIN, MOUSE; GAP JUNCTION PROTEIN; GGA ADAPTOR PROTEINS; GGA2 PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ARTICLE; CATARACT; CELL MEMBRANE; CELL ORGANELLE; CONTROLLED STUDY; GENE CLUSTER; GENE DISRUPTION; GENE MUTATION; GENE SILENCING; HEARING IMPAIRMENT; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PERIPHERAL NEUROPATHY; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RNA INTERFERENCE; TRANS GOLGI NETWORK; ANIMAL; GENETICS; HELA CELL; METABOLISM; MOUSE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CARRIER PROTEINS; CELL MEMBRANE; CONNEXINS; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; PROTEIN TRANSPORT; TRANS-GOLGI NETWORK;

EID: 77949440736     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp490     Document Type: Article

References (62)

1. Rodríguez-Boulan, E. and Müsch, A. (2005) Protein sorting in the Golgi complex: shifting paradigms. Biochim. Biophys. Acta, 1744, 455-464.
2. Bonifacino, J.S. and Traub, L.M. (2003) Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu. Rev. Biochem., 72, 395-447.
3. Rodríguez-Boulan, E., Kreitzer, G. and Müsch, A. (2005) Organization of vesicular trafficking in epithelia. Nat. Rev. Mol. Cell. Biol., 6, 233-247.
4. Ghosh, P., Dahms, N.M. and Kornfeld, S. (2003) Mannose 6-phosphate receptors: new twists in the tale. Nat. Rev. Mol. Cell. Biol., 4, 202-212.
5. Puertollano, R., Aguilar, R.C., Gorshkova, I., Crouch, R.J. and Bonifacino, J.S. (2001) Sorting of mannose 6-phosphate receptors mediated by the GGAs. Science, 292, 1712-1716.
6. Ghosh, P., Griffith, J., Geuze, H.J. and Kornfeld, S. (2003) Mammalian GGAs act together to sort mannose 6-phosphate receptors. J. Cell. Biol., 163, 755-766.
7. Bard, F. and Malhotra, V. (2006) The formation of TGN-to-plasma-membrane transport carriers. Annu. Rev. Cell. Dev. Biol., 22, 439-455.
8. Kumar, N.M. and Gilula, N.B. (1996) The gap junction communication channel. Cell, 84, 381-388.
9. Evans, W.H. and Martin, P.E.M. (2002) Gap junctions: structure and function. Mol. Memb. Biol., 19, 121-136.
10. Willecke, K., Eiberger, J., Degen, J., Eckardt, D., Romualdi, A., Güldenagel, M., Deutsch, U. and Söhl, G. (2002) Structural and functional diversity of connexin genes in the mouse and human genome. Biol. Chem., 383, 725-737.
11. Cruciani, V. and Mikalsen, S.O. (2006) The vertebrate connexin family. Cel. Mol. Life Sci., 63, 1125-1140.
12. Scemes, E., Spray, D.C. and Meda, P. (2009) Connexins, pannexins, innexins: novel roles of 'hemi-channels'. Pflugers Arch. - Eur. J. Physiol., 457, 1207-1226.
13. Laird, D.W. (2006) Life cycle of connexins in health and disease. Biochem. J., 394, 527-543.
14. Jin, C., Lau, A.F. and Martyn, K.D. (2000) Identification of connexin-interacting proteins: application of the yeast two-hybrid screen. Methods, 20, 219-231.
15. Lan, Z., Kurata, W.E., Martyn, K.D., Jin, C. and Lau, A.F. (2005) Novel Rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Biochemistry, 44, 2385-2396.
16. Akiyama, M., Ishida, N., Ogawa, T., Yogo, K. and Takeya, T. (2005) Molecular cloning and functional analysis of a novel Cx43 partner protein CIP150. Biochem. Biophys. Res. Comm., 335, 1264-1271.
17. Boëda, B., El-Amraoui, A., Bahloul, A., Goodyear, R., Daviet, L., Blanchard, S., Perfettini, I., Fath, K.R., Shorte, S., Reiners, J. et al. (2002) Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J., 21, 6689-6699.
18. Elfgang, C., Eckert, R., Lichtenberg-Fraté, H., Butterweck, A., Traub, O., Klein, R.A., Hülser, D.F. and Willecke, K. (1995) Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J. Cell Biol., 129, 805-817.
19. Phelan, P. and Starich, T.A. (2001) Innexins get into the gap. BioEssays, 23, 388-396.
20. Panchin, Y. (2005) Evolution of gap junction proteins-the pannexin alternative. J. Exp. Biol., 208, 1415-1419.
21. Panchin, Y., Kelmanson, I., Matz, M., Lukyanov, K., Usman, N. and Lukyanov, S. (2000) A ubiquitous family of putative gap junction molecules. Curr. Biol., 10, R473-R474.
22. Zhang, C.J., Rosenwald, A.G., Willingham, M.C., Skuntz, S., Clark, J. and Kalm, R.A. (1994) Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo. J. Cell Biol., 124, 289-300.
23. Reaves, B. and Banting, G. (1992) Perturbation of the morphology of the trans-Golgi network following Brefeldin A treatment: redistribution of a TGN-specific integral membrane protein, TGN38. J. Cell Bio.l, 116, 85-94.
24. Dell'Angelica, E.C., Puertollano, R., Mullins, C., Aguilar, R.C., Vargas, J.D., Hartnell, L.M. and Bonifacino, J.S. (2000) GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J. Cell Biol., 149, 81-94.
25. Boman, A.L., Zhang, C.J., Zhu, X. and Kahn, R.A. (2000) A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. Mol. Biol. Cell, 11, 1241-1255.
26. Hirst, J., Lui, W.W., Bright, N.A., Totty, N., Seaman, M.N. and Robinson, M.S. (2000) A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/ lysosome. J. Cell Biol., 149, 67-80.
27. Poussu, A., Lohi, O. and Lehto, V.P. (2000) Vear, a novel Golgi-associated protein with VHS and gamma-adaptin 'ear' domains. J. Biol. Chem., 275, 7176-7183.
28. Bonifacino, J.S. (2004) The GGA proteins: adaptors on the move. Nat. Rev. Mol. Cell Biol., 5, 23-32.
29. Zhu, Y., Doray, B., Poussu, A., Lehto, V.P. and Kornfeld, S. (2001) Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor. Science, 292, 1716-1718.
30. Nielsen, M.S., Madsen, P., Christensen, E.I., Nykjaer, A., Gliemann, J., Kasper, D., Pohlmann, R. and Petersen, C.M. (2001) The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J., 20, 2180-2190.
31. Takatsu, H., Katoh, Y., Shiba, Y. and Nakayama, K. (2001) Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. J. Biol. Chem., 276, 28541-28545.
32. Puertollano, R., Randazzo, P.A., Presley, J.F., Hartnell, L.M. and Bonifacino, J.S. (2001) The GGAs promote ARF-dependent recruitment of clathrin to the TGN. Cell, 105, 93-102.
33. Charpantier, E., Cancela, J. and Meda, P. (2007) Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels. Diabetologia, 50, 2332-2341.
34. Shaw, R.M., Fay, A.J., Puthenveedu, M.A., von Zastrow, M., Jan, Y.N. and Jan, L.Y. (2007) Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell, 128, 547-560.
35. Butkevich, E., Hülsmann, S., Wenzel, D., Shirao, T., Duden, R. and Majoul, I. (2004) Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton. Curr. Biol., 14, 650-658.
36. Ponnambalam, S. and Baldwin, S.A. (2003) Constitutive protein secretion from the trans-Golgi network to the plasma membrane. Mol. Membr. Bio.l, 20, 129-139.
37. Tompa, P. (2005) The interplay between structure and function in intrinsically unstructured proteins. FEBS Lett., 579, 3346-3354.
38. Martin, P.E.M., Blundell, G., Ahmad, S., Errington, R.J. and Evans, W.H. (2001) Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels. J. Cell Sci., 114, 3845-3855.
39. Thomas, T., Jordan, K., Simek, J., Shao, Q., Jedeszko, C., Walton, P. and Laird, D.W. (2005) Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J. Cell Sci., 118, 4451-4462.
40. Schotman, H., Karhinen, L. and Rabouille, C. (2008) dGRASP-mediated noncanonical integrin secretion is required for Drosophila epithelial remodeling. Dev. Cell, 14, 171-182.
41. Doray, B., Bruns, K., Ghosh, P. and Kornfeld, S.A. (2002) Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. Proc. Natl. Acad. Sci. USA, 99, 8072-8077.
42. Xie, L., Boyle, D., Sanford, D., Scherer, P.E., Pessin, J.E. and Mora, S. (2006) Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles. J. Biol. Chem., 281, 7253-7259.
43. Doray, B., Knisely, J.M., Wartman, L., Bu, G. and Kornfeld, S. (2008) Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2. Traffic, 9, 1551-1562.
44. Boucher, R., Larkin, H., Brodeur, J., Gagnon, H., Thériault, C. and Lavoie, C. (2008) Intracellular trafficking of LRP9 is dependent on two acidic cluster/dileucine motifs. Histochem. Cell Biol., 130, 315-327.
45. Fölsch, H., Pypaert, M., Maday, S., Pelletier, L. and Mellman, I. (2003) The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains. J. Cell Biol., 163, 351-362.
46. Ang, A.L., Taguchi, T., Francis, S., Fölsch, H., Murrells, L.J., Pypaert, M., Warren, G. and Mellman, I. (2004) Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. J. Cell Biol., 167, 531-543.
47. Li, L.V. and Kandror, K.V. (2005) Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors mediate insulin-responsive trafficking of glucose transporter 4 in 3T3-L1 adipocytes. Mol. Endocrinol., 19, 2145-2153.
48. Puertollano, R. and Bonifacino, J.S. (2004) Interactions of GGA3 with the ubiquitin sorting machinery. Nat. Cell Biol., 6, 244-251.
49. Dosztányi, Z., Csizmok, V., Tompa, P. and Simon, I. (2005) IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content. Bioinformatics, 21, 3433-3434.
50. Linding, R., Jensen, L.J., Diella, F., Bork, P., Gibson, T.J. and Russell, R.B. (2003) Protein disorder prediction: implications for structural proteomics. Structure, 11, 1453-1459.
51. Balla, S., Thapar, V., Verma, S., Luong, T.B., Faghri, T., Hsuang, C.H., Rajasekaran, S., del Campo, J.J., Shinn, J.H., Mohler, W.A. et al. (2006) Minimotif Miner: a tool for investigating protein function. Nat. Methods, 3, 175-177.
52. Puntervoll, P., Linding, R., Gemünd, C., Chabanis-Davidson, S., Mattingsdal, M., Cameron, S., Martin, D.M.A., Ausiello, G., Brannetti, B., Costantini, A. et al. (2003) ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucl. Acids Res., 31, 3625-3630.
53. Adato, A., Lefèvre, G., Delprat, B., Michel, V., Michalski, N., Chardenoux, S., Weil, D., El-Amraoui, A. and Petit, C. (2005) Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells. Hum. Mol. Genet., 14, 3921-3932.
54. Dell'Angelica, E.C., Ohno, H., Ooi, C.E., Rabinovich, E., Roche, K.W. and Bonifacino, J.S. (1997) AP-3: an adaptor-like protein complex with ubiquitous expression. EMBO J., 15, 917-928.
55. Sosinsky, G.E., Solan, J.L., Gaietta, G.M., Ngan, L., Lee, G.J., Mackey, M.R. and Lampe, P.D. (2007) The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies. Biochem. J., 408, 375-385.
56. Küssel-Andermann, P., El-Amraoui, A., Safieddine, S., Nouaille, S., Perfettini, I., Lecuit, M., Cossart, P., Wolfrim, U. and Petit, C. (2000) Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. EMBO J., 19, 6020-6029.
57. Silva, J.M., Li, M.Z., Chang, K., Ge, W., Golding, M.C., Rickles, R.J., Siolas, D., Hu, G., Paddison, P.J., Schlabach, M.R. et al. (2005) Second-generation shRNA libraries covering the mouse and human genomes. Nat. Genet., 37, 1281-1288.
58. Vozzi, C., Ullrich, S., Charollais, A., Philippe, J., Orci, L. and Meda, P. (1995) Adequate connexin-mediated coupling is required for proper insulin production. J. Cell Biol., 131, 1561-1572.
59. Zimmerli, S.C., Masson, F., Cancela, J., Meda, P. and Hauser, C. (2007) Lack of evidence for connexin-43 expression in human epidermal Langerhans cells. J. Immunol., 179, 4318-4321.
60. Tokuyasu, K.T. (1997) Immuno-cytochemistry on ultrathin cryosections. In Spector, D.L., Goodman, R.D. and Leinwand, L.A. (eds), Cells, A Laboratory Manual. CSHL Press, Cold Spring Harbor, USA, pp. 131.1-131.27.
61. Haefliger, J.A., Krattinger, N., Martin, D., Pedrazzini, T., Capponi, A., Doring, B., Plum, A., Charollais, A., Willecke, K. and Meda, P. (2006) Connexin43-dependent mechanism modulates renin secretion and hypertension. J. Clin. Invest., 116, 405-413.
62. Scheiermann, C., Meda, P., Aurrand-Lions, M., Madani, R., Yiangou, Y., Coffey, P., Salt, T.E., Ducrest-Gay, D., Caille, D., Howell, O. et al. (2007) Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science, 318, 1472-1475.